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UGID:138937     UniGene Hs.62578     Homo sapiens (human)   ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (ARFGEF2)

Human protein-coding gene ARFGEF2. Represented by 261 ESTs from 148 cDNA libraries. Corresponds to reference sequence NM_006420.2. [UniGene 138937 - Hs.62578]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_006411.2 ARFGEF2 gene product H. sapiens 100.0 1784
XP_003904687.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 2 P. anubis 99.9 1784
XP_001165584.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 3 P. troglodytes 99.9 1784
NP_001078964.1 Arfgef2 gene product M. musculus 97.5 1791
XP_002666513.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 2-like D. rerio 87.2 1830
NP_609675.2 sec71, isoform A D. melanogaster 69.8 1644
XP_962785.2 hypothetical protein NCU07658 N. crassa 56.6 614
NP_001021798.2 Protein AGEF-1, isoform a C. elegans 55.7 1553
NP_171698.1 SEC7-like guanine nucleotide exchange protein A. thaliana 53.6 899
XP_001694943.1 SEC7/BIG-like ARF-guanine nucleotide exchange factor C. reinhardtii 53.5 774
NP_010454.3 Sec7p S. cerevisiae 49.9 641
NP_001086260.1 cytohesin 2 X. laevis 49.8 207
Other hits (2 of 57) [Show all]SpeciesId(%)Len(aa)
XP_002798173.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 2-like M. mulatta 99.3 1742
XP_534448.1 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 2 C. lupus familiaris 99.0 1784

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; mixed; thymus; stomach; testis; mammary gland; pancreas; intestine; embryonic tissue; ovary; muscle; kidney; liver; lymph node; skin; uncharacterized tissue; placenta; uterus; eye; cervix; lung; pituitary gland; bone marrow; parathyroid; pharynx; blood; bladder; trachea; thyroid; epididymis; connective tissue; larynx; esophagus; spinal cord; ascites; adipose tissue; nerve; heart; bone; vascular; prostate
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 20
Map position: 20q13.13
UniSTS entry: Chr 20 STS-R64296
UniSTS entry: Chr 20 WI-17563 [Map Viewer]
UniSTS entry: Chr 20 SHGC-64065
UniSTS entry: RH81089
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

BC050449.1 Homo sapiens ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited), mRNA (cDNA clone IMAGE:6187759), partial cds PA
NM_006420.2 Homo sapiens ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (ARFGEF2), mRNA P
AF084521.1 Homo sapiens brefeldin A-inhibited guanine nucleotide-exchange protein 2 mRNA, complete cds P
AB209397.1 Homo sapiens mRNA for ADP-ribosylation factor guanine nucleotide-exchange factor 2 variant protein P
AK022623.1 Homo sapiens cDNA FLJ12561 fis, clone NT2RM4000798, highly similar to Brefeldin A-inhibited guanine nucleotide-exchange protein 2 P
AK074303.1 Homo sapiens cDNA FLJ23723 fis, clone HEP13970, highly similar to Homo sapiens brefeldin A-inhibited guanine nucleotide-exchange protein 2 mRNA PA
AK302526.1 Homo sapiens cDNA FLJ55398 complete cds, highly similar to Brefeldin A-inhibited guaninenucleotide-exchange protein 2 P
BC144625.1 Homo sapiens cDNA clone IMAGE:9053156 P
BC144626.1 Homo sapiens cDNA clone IMAGE:9053157 P

EST sequences (10 of 261) [Show all sequences]

AA972301.1 Clone IMAGE:1582890 mixed 3' read
AA988731.1 Clone IMAGE:1605384 kidney 3' read A
AI080432.1 Clone IMAGE:1662805 mixed 3' read A
CB044196.1 Clone IMAGE:3217460 intestine 3' read PA
BX112797.1 Clone IMAGp998G194012_;_IMAGE:1582890 mixed A
AI202366.1 Clone IMAGE:1943076 prostate 3' read
AI275443.1 Clone IMAGE:1877526 mixed 3' read A
AI289426.1 Clone IMAGE:1992827 uterus 3' read A
AA770081.1 Clone 1321133 testis 3' read
AI358380.1 Clone IMAGE:1991636 uterus 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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