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UGID:2070922     UniGene Hs.601911     Homo sapiens (human)   INPP5D
Inositol polyphosphate-5-phosphatase, 145kDa (INPP5D)

Human protein-coding gene INPP5D. Represented by 130 ESTs from 33 cDNA libraries. EST representation biased toward neonate. Corresponds to 2 reference sequences (different isoforms). [UniGene 2070922 - Hs.601911]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001017915.1 INPP5D gene product H. sapiens 100.0 1188
XP_526066.2 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2 P. troglodytes 99.6 928
NP_034696.2 Inpp5d gene product M. musculus 89.6 1189
NP_001083668.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 X. laevis 66.7 1008
XP_001923007.2 PREDICTED: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-like D. rerio 62.9 1101
Other hits (2 of 20) [Show all]SpeciesId(%)Len(aa)
XP_003908158.1 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, partial P. anubis 96.5 1243
XP_001495712.1 PREDICTED: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 E. caballus 92.5 1182

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: neonate [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lymph node; bone marrow; uncharacterized tissue; placenta; blood; mixed; spleen; lymph; kidney; brain; uterus; thymus; stomach; vascular; heart
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 2
Map position: 2q37.1
UniSTS entry: Chr 2 RH68337
UniSTS entry: Chr 2 RH68049
UniSTS entry: Chr 1 D11S2921
UniSTS entry: Chr 1 GDB:335751
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (14)

U53470.1 Human signaling inositol polyphosphate phosphatase SHIP II mRNA, complete cds P
NM_005541.3 Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 2, mRNA PA
NM_001017915.1 Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 1, mRNA PA
BC099920.1 Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa, mRNA (cDNA clone MGC:104855 IMAGE:6304992), complete cds PA
BC113582.1 Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa, mRNA (cDNA clone MGC:142142 IMAGE:8322634), complete cds P
BC113580.1 Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa, mRNA (cDNA clone MGC:142140 IMAGE:8322632), complete cds P
AK311547.1 Homo sapiens cDNA, FLJ18589 P
AK309644.1 Homo sapiens cDNA, FLJ99685 P
AK298651.1 Homo sapiens cDNA FLJ56795 complete cds, highly similar to Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 1, mRNA PA
X98429.1 H.sapiens mRNA for inositol polyphosphate 5-phosphatase P
U57650.1 Human SH2-containing inositol 5-phosphatase (hSHIP) mRNA, complete cds P
BC027960.1 Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa, mRNA (cDNA clone IMAGE:5223171), with apparent retained intron PA
U50041.1 Human signaling inositol polyphosphate 5 phosphatase SIP-145 mRNA, partial cds P
U84400.1 Human SH2 containing inositol-5-phosphatase (SHIP) mRNA, complete cds P

EST sequences (10 of 130) [Show all sequences]

AA922216.1 Clone IMAGE:1544079 mixed 3' read P
AI383786.1 Clone IMAGE:2074187 uncharacterized tissue 3' read P
BX342693.2 Clone CS0DL005YC14 uncharacterized tissue 5' read P
BX361594.2 Clone CS0DI087YN06 placenta 5' read P
AW080480.1 Clone IMAGE:2606463 mixed 3' read P
CF142802.1 Clone IMAGE:3101481 lymph node 5' read
CF135519.1 Clone IMAGE:3090117 lymph node 5' read P
CF136383.1 Clone IMAGE:3091576 lymph node 5' read P
CF136679.1 Clone IMAGE:3092906 lymph node 5' read
CF137311.1 Clone IMAGE:3091440 lymph node 5' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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