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UGID:2063006     UniGene Hs.593995     Homo sapiens (human)   TCF7L2
Transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2)

Human protein-coding gene TCF7L2. Represented by 311 ESTs from 146 cDNA libraries. Corresponds to 13 reference sequences (different isoforms). [UniGene 2063006 - Hs.593995]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001139746.1 TCF7L2 gene product H. sapiens 100.0 601
XP_001090054.2 PREDICTED: transcription factor 7-like 2-like M. mulatta 99.8 518
XP_003904313.1 PREDICTED: transcription factor 7-like 2 isoform 1 P. anubis 99.8 495
NP_001136394.1 Tcf7l2 gene product M. musculus 99.5 597
NP_571334.1 tcf7l2 gene product D. rerio 97.2 464
NP_001083866.1 transcription factor 7-like 2 X. laevis 93.8 481
NP_001033798.1 pangolin, isoform I D. melanogaster 64.6 291
Other hits (2 of 34) [Show all]SpeciesId(%)Len(aa)
XP_544024.3 PREDICTED: transcription factor 7-like 2 isoform 3 C. lupus familiaris 99.5 380
XP_003951826.1 PREDICTED: LOW QUALITY PROTEIN: transcription factor 7-like 2 P. troglodytes 99.0 528

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; mixed; lung; intestine; kidney; testis; uterus; connective tissue; mouth; vascular; eye; mammary gland; embryonic tissue; uncharacterized tissue; stomach; skin; heart; pancreas; prostate; blood; esophagus; trachea; thymus; bladder; ear; liver; cervix; parathyroid; spleen; placenta; ganglia; bone; ovary; larynx; thyroid; bone marrow; adrenal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10q25.3
UniSTS entry: Chr 10 RH11324
UniSTS entry: Chr 10 G43540
UniSTS entry: Chr 10 G20756
UniSTS entry: Chr 10 A006F09
UniSTS entry: Chr 10 WI-20234 [Map Viewer]
UniSTS entry: Chr 10 STS-T81462
UniSTS entry: Chr 10 SHGC-33545 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (54)

Y11306.2 Homo sapiens mRNA for hTCF-4 PA
BX648364.1 Homo sapiens mRNA; cDNA DKFZp686K06191 (from clone DKFZp686K06191) PA
AB034691.1 Homo sapiens TCF-4B mRNA for TCF-4 splice form B, partial cds
CR536574.1 Homo sapiens full open reading frame cDNA clone RZPDo834H0722D for gene TCF7L2, transcription factor 7-like 2 (T-cell specific, HMG-box); complete cds, incl. stopcodon P
AK225809.1 Homo sapiens mRNA for Splice isoform 8 of Q9NQB0 variant, clone: FCC130A07 PA
NM_030756.4 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 2, mRNA PA
AK054578.1 Homo sapiens cDNA FLJ30016 fis, clone 3NB692000429
AK315243.1 Homo sapiens cDNA, FLJ96245 P
BC032656.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box), mRNA (cDNA clone MGC:44932 IMAGE:5533185), complete cds PA
AK301483.1 Homo sapiens cDNA FLJ54563 complete cds, highly similar to Transcription factor 7-like 2 P
AK299295.1 Homo sapiens cDNA FLJ60833 complete cds, highly similar to Transcription factor 7-like 2 P
AK303684.1 Homo sapiens cDNA FLJ59810 complete cds, highly similar to Transcription factor 7-like 2 P
AK296305.1 Homo sapiens cDNA FLJ59705 complete cds, highly similar to Transcription factor 7-like 2 P
AB451266.1 Homo sapiens TCF7L2 mRNA for transcription factor 7-like 2, complete cds, clone: FLJ08086AAAN P
AK074705.1 Homo sapiens cDNA FLJ90224 fis, clone NT2RM1000789, highly similar to Mus musculus transcription factor 7-like 2, T-cell specific, HMG-box (Tcf7l2), mRNA P
AK316111.1 Homo sapiens cDNA, FLJ79010 complete cds, highly similar to Transcription factor 7-like 2 P
AB440195.1 Homo sapiens TCF7L2 mRNA for transcription factor 7-like 2 isoform, complete cds P
NM_001146274.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 1, mRNA PA
NM_001146286.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 6, mRNA PA
NM_001146285.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 5, mRNA PA
NM_001146284.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 4, mRNA PA
NM_001146283.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 3, mRNA PA
FJ010174.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14 mRNA, complete cds, alternatively spliced P
FJ010173.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_H2_ex3-11-12-13-14 mRNA, complete cds, alternatively spliced P
FJ010172.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_B8_ex1-11-14 mRNA, complete cds, alternatively spliced P
FJ010171.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_B4_ex1-no4-11-14 mRNA, complete cds, alternatively spliced P
FJ010170.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_ex1-11-12-14 mRNA, complete cds, alternatively spliced P
FJ010169.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_B1_ex1-11-12-13-13b mRNA, complete cds, alternatively spliced P
FJ010168.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_H7_ex1-11-13-13b mRNA, complete cds, alternatively spliced P
FJ010167.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_D4,ex1-11-13a-14 mRNA, complete cds, alternatively spliced P
FJ010166.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_A3,ex1-12,13,13a mRNA, complete cds, alternatively spliced P
FJ010165.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_D5_ex3,4a-11,12,13a,14 mRNA, complete cds, alternatively spliced P
FJ010164.1 Homo sapiens TCF7L2 isoform pFC8A_TCF7L2_D5_ex3-11,12,13a,14 mRNA, complete cds, alternatively spliced P
HM352845.1 Homo sapiens T-cell factor-4 variant X2 (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352851.1 Homo sapiens T-cell factor-4 variant L (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352850.1 Homo sapiens T-cell factor-4 variant M (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352849.1 Homo sapiens T-cell factor-4 variant A (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352848.1 Homo sapiens T-cell factor-4 variant E (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352847.1 Homo sapiens T-cell factor-4 variant J (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352846.1 Homo sapiens T-cell factor-4 variant G (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352844.1 Homo sapiens T-cell factor-4 variant I (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352843.1 Homo sapiens T-cell factor-4 variant C (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352842.1 Homo sapiens T-cell factor-4 variant B (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352841.1 Homo sapiens T-cell factor-4 variant H (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352840.1 Homo sapiens T-cell factor-4 variant D (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352839.1 Homo sapiens T-cell factor-4 variant K (TCF7L2) mRNA, complete cds, alternatively spliced P
HM352838.1 Homo sapiens T-cell factor-4 variant F (TCF7L2) mRNA, complete cds, alternatively spliced P
NM_001198531.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 13, mRNA P
NM_001198530.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 12, mRNA P
NM_001198529.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 11, mRNA P
NM_001198528.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 10, mRNA P
NM_001198527.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 9, mRNA P
NM_001198526.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 8, mRNA P
NM_001198525.1 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 7, mRNA P

EST sequences (10 of 311) [Show all sequences]

AA988308.1 Clone IMAGE:1607025 mammary gland 3' read A
AA993514.1 Clone IMAGE:1623130 embryonic tissue 3' read A
AA904390.1 Clone IMAGE:1523555 mixed 3' read A
AI027235.1 Clone IMAGE:1644462 testis 3' read A
AI055950.1 Clone IMAGE:1659191 embryonic tissue 3' read
AI090490.1 Clone IMAGE:1692076 heart 3' read A
AA910057.1 Clone IMAGE:1525947 mixed 3' read A
AI123812.1 Clone IMAGE:1651283 mixed 3' read
AI084440.1 Clone IMAGE:1662075 mixed 3' read A
CB044922.1 Clone IMAGE:3218018 intestine 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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