NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
Finding cDNAs

UGID:2062424     UniGene Hs.593413     Homo sapiens (human)   CXCR4
Chemokine (C-X-C motif) receptor 4 (CXCR4)

Human protein-coding gene CXCR4. Represented by 385 ESTs from 176 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 2062424 - Hs.593413]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001008540.1 CXCR4 gene product H. sapiens 100.0 355
NP_001009047.1 CXCR4 gene product P. troglodytes 100.0 351
NP_001106100.1 CXCR4 gene product P. anubis 99.7 351
NP_034041.2 Cxcr4 gene product M. musculus 92.9 353
NP_001080681.1 C-X-C chemokine receptor type 4-B X. laevis 80.6 355
NP_571957.2 cxcr4a gene product D. rerio 75.6 347
Other hits (2 of 21) [Show all]SpeciesId(%)Len(aa)
NP_001036110.1 CXCR4 gene product M. mulatta 99.4 351
XP_002712170.1 PREDICTED: chemokine (C-X-C motif) receptor 4 O. cuniculus 98.6 351

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: blood; brain; uncharacterized tissue; mixed; uterus; spleen; thymus; mouth; intestine; pancreas; pharynx; embryonic tissue; adrenal gland; placenta; stomach; esophagus; cervix; connective tissue; muscle; kidney; prostate; lung; lymph node; ear; adipose tissue; larynx; heart; ovary; mammary gland; lymph; testis; trachea; bone marrow; tonsil; eye; thyroid; pituitary gland; vascular; nerve; ganglia; umbilical cord; bone; liver
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 2
Map position: 2q21
UniSTS entry: Chr 2 RH17365
UniSTS entry: Chr 2 RH78321
UniSTS entry: Chr 2 PMC110622P1
UniSTS entry: Chr 2 PMC109444P3
UniSTS entry: Chr 2 SHGC-31461
UniSTS entry: Chr 2 PMC109434P1
UniSTS entry: Chr 2 PMC109895P1
UniSTS entry: Chr 2 Cxcr4
UniSTS entry: Chr 2 PMC149544P1
UniSTS entry: Chr 2 PMC112647P1
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

BT006660.1 Homo sapiens chemokine (C-X-C motif) receptor 4 mRNA, complete cds P
AY242129.1 Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4) mRNA, complete cds P
AK129916.1 Homo sapiens cDNA FLJ26406 fis, clone HRT09192, highly similar to C-X-C chemokine receptor type 4 P
NM_003467.2 Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, mRNA PA
L06797.1 Human (clone L5) orphan G protein-coupled receptor mRNA, complete cds PA
AY826773.1 Homo sapiens clone CXCR4-3 chemokine receptor 4 (CXCR4) mRNA, partial cds
NM_001008540.1 Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 1, mRNA PA
AF147204.1 Homo sapiens chemokine receptor CXCR4-Lo (CXCR4) mRNA, alternatively spliced, complete cds PA
D10924.1 Homo sapiens mRNA for HM89, complete cds PA
L01639.1 Human (clone HSY3RR) neuropeptide Y receptor (NPYR) mRNA, complete cds P
AF348491.1 Homo sapiens chemokine receptor CXCR4 mRNA, complete cds P
M99293.1 Homo sapiens seven transmembrane segment receptor mRNA, complete cds P
BC020968.2 Homo sapiens chemokine (C-X-C motif) receptor 4, mRNA (cDNA clone MGC:9199 IMAGE:3846345), complete cds PA
AK309885.1 Homo sapiens cDNA, FLJ99926 P
AK309641.1 Homo sapiens cDNA, FLJ99682 P
AK312244.1 Homo sapiens cDNA, FLJ92538, highly similar to Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), mRNA P
AK296674.1 Homo sapiens cDNA FLJ51543 complete cds, highly similar to C-X-C chemokine receptor type 4 P
X71635.1 H.sapiens mRNA for neuropeptide Y-like receptor P
AF025375.1 Homo sapiens chemokine receptor-4 (CXCR4) mRNA, complete cds P

EST sequences (10 of 385) [Show all sequences]

AI002547.1 Clone IMAGE:1593624 kidney 3' read A
AI022030.1 Clone IMAGE:1652348 mixed 3' read A
AI050023.1 Clone IMAGE:1699403 kidney 3' read A
R23114.1 Clone IMAGE:130943 placenta 5' read
R23115.1 Clone IMAGE:130943 placenta 3' read A
AI159856.1 Clone IMAGE:1703632 brain 3' read A
BX089192.1 Clone IMAGp998K201853_;_IMAGE:753931 mixed P
AI193140.1 Clone IMAGE:1741487 lung 3' read A
AI249788.1 Clone IMAGE:2004882 pancreas 3' read A
CB122606.1 Clone L10ChoCK0-13-D07 liver 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help