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UGID:2062424     UniGene Hs.593413     Homo sapiens (human)   CXCR4
Chemokine (C-X-C motif) receptor 4 (CXCR4)

Human protein-coding gene CXCR4. Represented by 385 ESTs from 176 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 2062424 - Hs.593413]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001008540.1 CXCR4 gene product H. sapiens 100.0 355
NP_001009047.1 CXCR4 gene product P. troglodytes 100.0 351
NP_001106100.1 CXCR4 gene product P. anubis 99.7 351
NP_034041.2 Cxcr4 gene product M. musculus 92.9 353
NP_001080681.1 C-X-C chemokine receptor type 4-B X. laevis 80.6 355
NP_571957.2 cxcr4a gene product D. rerio 75.6 347
Other hits (2 of 21) [Show all]SpeciesId(%)Len(aa)
NP_001036110.1 CXCR4 gene product M. mulatta 99.4 351
XP_002712170.1 PREDICTED: chemokine (C-X-C motif) receptor 4 O. cuniculus 98.6 351

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: blood; brain; uncharacterized tissue; mixed; uterus; spleen; thymus; mouth; intestine; pancreas; pharynx; embryonic tissue; adrenal gland; placenta; stomach; esophagus; cervix; connective tissue; muscle; kidney; prostate; lung; lymph node; ear; adipose tissue; larynx; heart; ovary; mammary gland; lymph; testis; trachea; bone marrow; tonsil; eye; thyroid; pituitary gland; vascular; nerve; ganglia; umbilical cord; bone; liver
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 2
Map position: 2q21
UniSTS entry: Chr 2 RH17365
UniSTS entry: Chr 2 RH78321
UniSTS entry: Chr 2 PMC110622P1
UniSTS entry: Chr 2 PMC109444P3
UniSTS entry: Chr 2 SHGC-31461
UniSTS entry: Chr 2 PMC109434P1
UniSTS entry: Chr 2 PMC109895P1
UniSTS entry: Chr 2 Cxcr4
UniSTS entry: Chr 2 PMC149544P1
UniSTS entry: Chr 2 PMC112647P1
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

BT006660.1 Homo sapiens chemokine (C-X-C motif) receptor 4 mRNA, complete cds P
AY242129.1 Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4) mRNA, complete cds P
AK129916.1 Homo sapiens cDNA FLJ26406 fis, clone HRT09192, highly similar to C-X-C chemokine receptor type 4 P
NM_003467.2 Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, mRNA PA
L06797.1 Human (clone L5) orphan G protein-coupled receptor mRNA, complete cds PA
AY826773.1 Homo sapiens clone CXCR4-3 chemokine receptor 4 (CXCR4) mRNA, partial cds
NM_001008540.1 Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 1, mRNA PA
AF147204.1 Homo sapiens chemokine receptor CXCR4-Lo (CXCR4) mRNA, alternatively spliced, complete cds PA
D10924.1 Homo sapiens mRNA for HM89, complete cds PA
L01639.1 Human (clone HSY3RR) neuropeptide Y receptor (NPYR) mRNA, complete cds P
AF348491.1 Homo sapiens chemokine receptor CXCR4 mRNA, complete cds P
M99293.1 Homo sapiens seven transmembrane segment receptor mRNA, complete cds P
BC020968.2 Homo sapiens chemokine (C-X-C motif) receptor 4, mRNA (cDNA clone MGC:9199 IMAGE:3846345), complete cds PA
AK309885.1 Homo sapiens cDNA, FLJ99926 P
AK309641.1 Homo sapiens cDNA, FLJ99682 P
AK312244.1 Homo sapiens cDNA, FLJ92538, highly similar to Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), mRNA P
AK296674.1 Homo sapiens cDNA FLJ51543 complete cds, highly similar to C-X-C chemokine receptor type 4 P
X71635.1 H.sapiens mRNA for neuropeptide Y-like receptor P
AF025375.1 Homo sapiens chemokine receptor-4 (CXCR4) mRNA, complete cds P

EST sequences (10 of 385) [Show all sequences]

AI002547.1 Clone IMAGE:1593624 kidney 3' read A
AI022030.1 Clone IMAGE:1652348 mixed 3' read A
AI050023.1 Clone IMAGE:1699403 kidney 3' read A
R23114.1 Clone IMAGE:130943 placenta 5' read
R23115.1 Clone IMAGE:130943 placenta 3' read A
AI159856.1 Clone IMAGE:1703632 brain 3' read A
BX089192.1 Clone IMAGp998K201853_;_IMAGE:753931 mixed P
AI193140.1 Clone IMAGE:1741487 lung 3' read A
AI249788.1 Clone IMAGE:2004882 pancreas 3' read A
CB122606.1 Clone L10ChoCK0-13-D07 liver 5' read P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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