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UGID:2061060     UniGene Hs.592049     Homo sapiens (human)   PLK1
Polo-like kinase 1 (PLK1)

Human protein-coding gene PLK1. Represented by 768 ESTs from 225 cDNA libraries. Corresponds to reference sequence NM_005030.3. [UniGene 2061060 - Hs.592049]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001092070.1 PREDICTED: serine/threonine-protein kinase PLK1 isoform 1 M. mulatta 100.0 602
XP_003916730.1 PREDICTED: serine/threonine-protein kinase PLK1 P. anubis 100.0 602
NP_005021.2 PLK1 gene product H. sapiens 100.0 602
XP_001163623.2 PREDICTED: serine/threonine-protein kinase PLK1 isoform 2 P. troglodytes 99.7 693
NP_035251.3 Plk1 gene product M. musculus 97.8 602
NP_001080788.1 serine/threonine-protein kinase PLK1 X. laevis 88.4 597
NP_001003890.3 plk1 gene product D. rerio 83.1 591
NP_524179.2 polo, isoform A D. melanogaster 64.3 571
NP_001021173.1 Protein PLK-1, isoform a C. elegans 63.6 630
NP_013714.1 polo kinase CDC5 S. cerevisiae 54.9 299
XP_964693.1 hypothetical protein NCU09258 N. crassa 49.2 268
Other hits (2 of 45) [Show all]SpeciesId(%)Len(aa)
XP_002711895.1 PREDICTED: polo-like kinase 1 O. cuniculus 99.3 603
XP_547091.3 PREDICTED: serine/threonine-protein kinase PLK1 C. lupus familiaris 98.7 603

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: testis; brain; uncharacterized tissue; skin; liver; ascites; lung; intestine; eye; bone; tonsil; salivary gland; pancreas; embryonic tissue; thymus; mammary gland; cervix; kidney; uterus; bone marrow; placenta; lymph; mixed; ovary; connective tissue; lymph node; spleen; blood; prostate; stomach; muscle; umbilical cord; thyroid; bladder; esophagus; amniotic fluid; vascular; mouth; heart; parathyroid; trachea
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 16
Map position: 16p12.2
UniSTS entry: Chr 16 G06491
UniSTS entry: Chr 16 RH104431
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

L19559.1 Homo sapiens protein kinase (HSTPK13) mRNA, complete cds P
NM_005030.3 Homo sapiens polo-like kinase 1 (PLK1), mRNA PA
U01038.1 Human pLK mRNA, complete cds PA
AB084459.1 Homo sapiens mRNA for polo-like kinase 1 delta, complete cds PA
BC003002.1 Homo sapiens polo-like kinase 1 (Drosophila), mRNA (cDNA clone MGC:3988 IMAGE:2823623), complete cds PA
BC002369.2 Homo sapiens polo-like kinase 1 (Drosophila), mRNA (cDNA clone MGC:8502 IMAGE:2822226), complete cds PA
BC014846.1 Homo sapiens polo-like kinase 1 (Drosophila), mRNA (cDNA clone MGC:9748 IMAGE:3854860), complete cds PA
AK308276.1 Homo sapiens cDNA, FLJ98224 P
AK313227.1 Homo sapiens cDNA, FLJ93730, highly similar to Homo sapiens polo-like kinase (Drosophila) (PLK), mRNA P
AK303263.1 Homo sapiens cDNA FLJ51423 complete cds, highly similar to Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) P
X73458.1 H.sapiens plk-1 mRNA P
X75932.1 H.sapiens PLK mRNA for serine/threonine protein kinase P

EST sequences (10 of 768) [Show all sequences]

AA991721.1 Clone IMAGE:1612808 uncharacterized tissue 3' read A
R17934.1 Clone IMAGE:125030 mixed 3' read A
R18033.1 Clone IMAGE:125017 mixed 5' read
AI218478.1 Clone IMAGE:1845944 mixed 3' read A
AI221870.1 Clone IMAGE:1842837 mixed 3' read A
CB157317.1 Clone L17N670205n1-3-A07 liver 5' read P
CB161560.1 Clone L17N670205n1-35-B11 liver 5' read P
CB163827.1 Clone L17N670205n1-28-B12 liver 5' read P
CB160392.1 Clone L18POOL1n1-17-C01 liver 5' read P
CB163012.1 Clone L18POOL1n1-44-B07 liver 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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