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UGID:1953564     UniGene Hs.584775     Homo sapiens (human)   LRP6
Low density lipoprotein receptor-related protein 6 (LRP6)

Human protein-coding gene LRP6. Represented by 170 ESTs from 100 cDNA libraries. Corresponds to reference sequence NM_002336.2. [UniGene 1953564 - Hs.584775]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_002327.2 LRP6 gene product H. sapiens 100.0 1612
XP_002808022.1 PREDICTED: LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6-like M. mulatta 99.9 1612
XP_003906060.1 PREDICTED: low-density lipoprotein receptor-related protein 6 isoform 1 P. anubis 99.9 1612
XP_001152103.1 PREDICTED: low-density lipoprotein receptor-related protein 6 isoform 1 P. troglodytes 99.9 1612
XP_001501348.1 PREDICTED: low-density lipoprotein receptor-related protein 6 isoform 1 E. caballus 99.5 1612
NP_032540.2 low-density lipoprotein receptor-related protein 6 precursor M. musculus 98.8 1612
NP_001079233.1 low density lipoprotein receptor-related protein 6 precursor X. laevis 87.1 1612
NP_001128156.1 lrp6 gene product D. rerio 84.0 1619
NP_524737.2 arrow D. melanogaster 57.7 478
Other hits (2 of 34) [Show all]SpeciesId(%)Len(aa)
XP_534886.2 PREDICTED: low-density lipoprotein receptor-related protein 6 isoform 1 C. lupus familiaris 99.4 1612
XP_002712701.1 PREDICTED: low density lipoprotein receptor-related protein 6 O. cuniculus 99.3 1612

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; ear; uncharacterized tissue; placenta; liver; pancreas; intestine; embryonic tissue; kidney; uterus; stomach; lung; testis; trachea; heart; mixed; prostate; parathyroid; eye; mammary gland; ovary; skin; muscle; bone; blood; cervix; thyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12p13.2
UniSTS entry: Chr 12 RH70320 [Map Viewer]
UniSTS entry: Chr 12 BTA05_16075:706838514:1
UniSTS entry: Chr 12 Lrp6
UniSTS entry: Chr 12 RH80314
UniSTS entry: Lrp6
UniSTS entry: Chr 12 LRP6_4011
UniSTS entry: Chr 12 SGC33317 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

AF074264.1 Homo sapiens LDL receptor-related protein 6 (LRP6) mRNA, complete cds PA
AK124760.1 Homo sapiens cDNA FLJ42770 fis, clone BRAWH3003727 A
NM_002336.2 Homo sapiens low density lipoprotein receptor-related protein 6 (LRP6), mRNA PA
AB209683.1 Homo sapiens mRNA for low density lipoprotein receptor-related protein 6 variant protein P
BC117136.1 Homo sapiens low density lipoprotein receptor-related protein 6, mRNA (cDNA clone MGC:150745 IMAGE:40125687), complete cds P
BC126405.1 Homo sapiens low density lipoprotein receptor-related protein 6, mRNA (cDNA clone MGC:161683 IMAGE:8992121), complete cds P
AK074902.1 Homo sapiens cDNA FLJ90421 fis, clone NT2RP3000304, highly similar to Low-density lipoprotein receptor-related protein 6 precursor P
AK074543.1 Homo sapiens cDNA FLJ90062 fis, clone HEMBA1003392, highly similar to Low-density lipoprotein receptor-related protein 6 precursor P
BC143725.1 Homo sapiens low density lipoprotein receptor-related protein 6, mRNA (cDNA clone MGC:177256 IMAGE:9052239), complete cds P

EST sequences (10 of 170) [Show all sequences]

AI140147.1 Clone IMAGE:1693765 heart 3' read A
AI140433.1 Clone IMAGE:1692887 heart 3' read A
AI144434.1 Clone IMAGE:1708876 heart 3' read A
R24513.1 Clone IMAGE:131820 placenta 3' read
R24616.1 Clone IMAGE:131820 placenta 5' read
AI151494.1 Clone IMAGE:1715397 placenta 3' read A
AI160673.1 Clone IMAGE:1721379 uterus 3' read A
BX111315.1 Clone IMAGp998A215412_;_IMAGE:2189852 uterus A
BX113184.1 Clone IMAGp998I09872_;_IMAGE:377168 heart A
AI174424.1 Clone IMAGE:1701694 kidney 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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