NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
Finding cDNAs

UGID:1370636     UniGene Hs.534322     Homo sapiens (human)   HLA-DRB1
Major histocompatibility complex, class II, DR beta 1 (HLA-DRB1)

Human protein-coding gene HLA-DRB1. Represented by 523 ESTs from 190 cDNA libraries. Corresponds to reference sequence NM_002125.3. [UniGene 1370636 - Hs.534322]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_002116.2 HLA-DRB5 gene product H. sapiens 100.0 265
NP_034512.2 H2-Eb1 gene product M. musculus 83.0 263
NP_001177324.1 uncharacterized protein LOC100462907 precursor X. laevis 53.9 258
Other hits (2 of 16) [Show all]SpeciesId(%)Len(aa)
XP_001165809.3 PREDICTED: HLA class II histocompatibility antigen, DR beta 5 chain isoform 8 P. troglodytes 95.9 265
NP_001035119.1 MAMU-DRB5 gene product M. mulatta 94.0 265

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lung; tonsil; mixed; brain; lymph; stomach; lymph node; uterus; uncharacterized tissue; embryonic tissue; intestine; bone marrow; esophagus; spleen; thyroid; kidney; pancreas; testis; pharynx; liver; adrenal gland; mammary gland; vascular; placenta; blood; connective tissue; eye; ovary; thymus; bladder; trachea; skin; mouth; larynx; ascites; prostate; adipose tissue; heart; muscle; salivary gland; ganglia; pineal gland; pituitary gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 6
Map position: 6p21.3
UniSTS entry: Chr 6 GDB:177509
UniSTS entry: Chr 6 RH69091 [Map Viewer]
UniSTS entry: RH76259
UniSTS entry: Chr 6 RH15772
UniSTS entry: Chr 6 RH80065
UniSTS entry: Chr 6 RH69092
UniSTS entry: RH80800
UniSTS entry: RH46825
UniSTS entry: RH79846
UniSTS entry: Chr 6 RH69085 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (51)

M15178.1 Human HLA-DR beta-chain mRNA, partial cds P
M16954.1 Human MHC class II HLA-DR2 (Dw2) a-associated glycoprotein beta-chain mRNA, 3' end P
M16956.1 Human MHC class II HLA-DR2 (non-Dw2/non-Dw12) a-associated glycoprotein beta-chain mRNA, 3' end P
M17383.1 Human MHC class II HLA-DR-beta mRNA (DR6), partial cds P
M17384.1 Human MHC class II HLA-DR-beta mRNA (DR7), partial cds P
AF490771.1 Homo sapiens MHC class II antigen (HLA-DRB1) mRNA, HLA-DRB1*1401 allele, partial cds P
NM_002125.3 Homo sapiens major histocompatibility complex, class II, DR beta 5 (HLA-DRB5), mRNA P
U66826.1 Homo sapiens MHC class II antigen (HLA-DRB1) mRNA, HLA-DRB1*09012 allele, complete cds P
M15992.1 Human (clone FJ0-6) MHC class II DR subtype Dw2 mRNA, 3' end, haplotype HLA-DR2 P
M16086.1 Human (clone DHO-7) MHC class II DR subtype Dw12 mRNA, 3' end, haplotype HLA-DR2 P
M32578.1 Human MHC class II HLA-DR beta-1 mRNA (DR2.3), 5'end P
M17377.1 Homo sapiens MHC HLA-DR-beta cell surface glycoprotein (HLA-DRB2) mRNA, partial cds P
M20429.1 Human MHC class II HLA-DR-beta mRNA (DR2-DQw1/DR4 DQw3), complete cds, clone ROF-beta-2a P
M20503.1 Human MHC class II HLA-DR-beta-1 mRNA, complete cds P
M27689.1 Human MHC class II HLA-DR beta gene (DR3,w18,DQw4-beta-I), 3' end P
M57648.1 Human MHC HLA-Dw12 mRNA, complete cds P
BC009234.2 Homo sapiens major histocompatibility complex, class II, DR beta 5, mRNA (cDNA clone MGC:16550 IMAGE:4054398), complete cds PA
AB062112.2 Homo sapiens HLA-DRB1*1405 mRNA for MHC class II antigen, complete cds P
AK290388.1 Homo sapiens cDNA FLJ78730 complete cds, highly similar to Homo sapiens major histocompatibility complex, class II, DR beta 1, mRNA P
AK292140.1 Homo sapiens cDNA FLJ76359 complete cds, highly similar to Homo sapiens major histocompatibility complex, class II, DR beta 3, mRNA PA
AK314834.1 Homo sapiens cDNA, FLJ95720, Homo sapiens major histocompatibility complex, class II, DR beta 5(HLA-DRB5), mRNA P
X99895.1 H.sapiens mRNA for major histocompatability complex class II, DRB1*1327 P
FJ200455.1 Homo sapiens MHC class II antigen (HLA-DRB1) mRNA, HLA-DRB1*14 variant allele, partial cds P
AY052550.1 Homo sapiens MHC class II antigen (HLA-DRB1) mRNA, HLA-DRB1*1408 variant allele, exon 2 and partial cds P
AF436097.1 Homo sapiens MHC class II antigen (HLA-DRB) mRNA, HLA-DRB1*0411 allele, partial cds P
AY054375.1 Homo sapiens MHC class II antigen (HLA-DRB1) mRNA, HLA-DRB1*1414 allele, partial cds P
AF097680.1 Homo sapiens MHC class II antigen (HLA-DRB5) pseudogene, partial sequence P
S79787.1 HLA-DQB1 (DQB1*02)=human leucocyte antigen [human, cell 141, mRNA Partial, 201 nt]
U95818.1 Human MHC class II antigen HLA-DR-beta 1 mRNA (DRB1*11011 allele), partial sequence P
U17381.1 Human MHC class I HLA-DRB1 gene (HLA-DRB1308V allele) mRNA, partial cds P
U17380.1 Human MHC class I HLA-DRB1 gene (HLA-DR1101V allele) mRNA, partial cds P
AJ011065.1 Homo sapiens mRNA for HLA-DRB1*04, partial P
AF017440.1 Homo sapiens MHC class II antigen HLA-DR4-beta 1 (HLA-DRB1*0406 allele) mRNA, partial cds P
U31770.1 Homo sapiens HLA-drb5 (DRB5*0104) mRNA, partial cds P
U37433.1 Human class II histocompatibility antigen HLA DR alpha, beta1-0307 mRNA, partial cds P
U37582.1 Human DRB52 mRNA, partial cds P
U35729.1 Human MHC class II HLA-DR-beta (HLA-DRB1-03011 allele) mRNA, partial cds P
U35375.1 Human MHC class II antigen (HLA-DRB52) mRNA, partial cds P
M59803.1 Human MHC class II DRB1 mRNA (DRw13), partial cds P
M30181.1 Human MHC class II HLA-DR-beta chain mRNA (DR2,MN2), 5' end, clone MN2-2 P
M16731.1 Human MHC class II HLA-DR4 I first domain coding region fo DR-beta chain mRNA (Dw4) P
M15068.1 Human MHC class II HLA-DR-beta-1 chain mRNA (DR4,Dw10), partial cds P
M30182.1 Human MHC class II HLA-DR-beta mRNA (DR2,Dw12), partial cds, clone DHO-7
M25265.1 Homo sapiens MHC class II lymphocyte antigen mRNA, partial cds, haplotype DRw13 DQw1 P
M17387.1 Human MHC class II HLA-DR-beta mRNA (DR9), partial cds P
M35981.1 Human MHC class II HLA-DR-beta chain mRNA, 5' end
M35980.1 Human MHC class II HLA-DR-beta chain mRNA, 5' end
M16955.1 Human MHC class II HLA-DR2 (Dw12) a-associated glycoprotein beta-chain mRNA, 3' end P
M27015.1 Human lymphocyte antigen (DRw8) mRNA P
U70543.1 Homo sapiens MHC class II antigen (HLA-DRB4) pseudogene mRNA, null allele HLA-DRB4*0201N, partial cds P
HM627215.1 Homo sapiens MHC class II antigen (HLA-DR) mRNA, HLA-DR*08 variant allele, complete cds P

EST sequences (10 of 523) [Show all sequences]

AA903260.1 Clone IMAGE:1517297 uncharacterized tissue 3' read
AA970433.1 Clone IMAGE:1576397 intestine 3' read P
AI186636.1 Clone IMAGE:1725295 placenta 3' read A
AA903569.1 Clone IMAGE:1518611 uncharacterized tissue 3' read A
AA947943.1 Clone IMAGE:1416003 lung 3' read
AI199893.1 Clone IMAGE:1757831 placenta 3' read
AI302703.1 Clone IMAGE:1898502 lung 3' read P
AI302797.1 Clone IMAGE:1902461 kidney 3' read A
AI350420.1 Clone IMAGE:1947841 uncharacterized tissue 3' read
AI431470.1 Clone IMAGE:2120751 lymph node 3' read PA


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help