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UGID:1293157     UniGene Hs.533782     Homo sapiens (human)   KRT8
Keratin 8 (KRT8)

Human protein-coding gene KRT8. Represented by 2894 ESTs from 390 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 1293157 - Hs.533782]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001243211.1 KRT8 gene product H. sapiens 100.0 510
XP_001142346.1 PREDICTED: keratin, type II cytoskeletal 8 isoform 3 P. troglodytes 100.0 365
XP_002798643.1 PREDICTED: keratin, type II cytoskeletal 8 isoform 3 M. mulatta 99.6 516
XP_003906486.1 PREDICTED: keratin, type II cytoskeletal 8 P. anubis 99.6 516
NP_112447.2 Krt8 gene product M. musculus 95.5 489
NP_001091278.1 uncharacterized protein LOC100037087 X. laevis 95.5 489
NP_001036387.1 ribosomal protein L5, isoform A D. melanogaster 82.0 89
NP_956374.1 krt8 gene product D. rerio 79.9 518
NP_495811.1 Protein RPL-5 C. elegans 75.3 89
Other hits (2 of 37) [Show all]SpeciesId(%)Len(aa)
XP_002708774.1 PREDICTED: keratin 8-like O. cuniculus 96.5 483
NP_955402.1 Krt8 gene product R. norvegicus 95.2 482

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: placenta; intestine; pancreas; mammary gland; uterus; embryonic tissue; stomach; liver; prostate; ovary; lung; mixed; kidney; ascites; lymph node; uncharacterized tissue; cervix; eye; thyroid; bladder; larynx; esophagus; brain; bone; epididymis; amniotic fluid; heart; skin; bone marrow; mouth; lymph; adipose tissue; testis; pituitary gland; muscle; parathyroid; pharynx; connective tissue; vascular
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12q13
UniSTS entry: Chr 8 D17S1697
UniSTS entry: Chr 8 RH79790
UniSTS entry: Chr 15 GDB:277179
UniSTS entry: Chr 12 RH47175 [Map Viewer]
UniSTS entry: Chr 1 KRT8_7288
UniSTS entry: Chr 12 GDB:376877
UniSTS entry: GDB:583337
UniSTS entry: Chr 1 RH102946
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (22)

NM_002273.3 Homo sapiens keratin 8 (KRT8), transcript variant 2, mRNA PA
BC063513.1 Homo sapiens keratin 8, mRNA (cDNA clone MGC:75150 IMAGE:3879823), complete cds PA
BC073760.1 Homo sapiens keratin 8, mRNA (cDNA clone MGC:88767 IMAGE:2963092), complete cds PA
BC075839.1 Homo sapiens keratin 8, mRNA (cDNA clone MGC:88746 IMAGE:6285632), complete cds PA
AK222941.1 Homo sapiens mRNA for keratin 8 variant, clone: HRC09415 PA
BC000654.2 Homo sapiens keratin 8, mRNA (cDNA clone MGC:1711 IMAGE:3349233), complete cds PA
BC008200.1 Homo sapiens keratin 8, mRNA (cDNA clone MGC:5377 IMAGE:3445666), complete cds PA
BC011373.1 Homo sapiens keratin 8, mRNA (cDNA clone IMAGE:3447242), partial cds PA
AK290938.1 Homo sapiens cDNA FLJ77754 complete cds, highly similar to Homo sapiens keratin 8 (KRT8), mRNA P
X98614.1 H.sapiens mRNA for cytokeratin PA
AK310257.1 Homo sapiens cDNA, FLJ17299 P
AK315826.1 Homo sapiens cDNA, FLJ79475 complete cds, highly similar to Keratin, type II cytoskeletal 8 PA
D28446.1 Homo sapiens mRNA for cytokeratin 8, 5'UTR region
Z36777.1 H.sapiens (xs11) mRNA, 393bp P
X74929.1 H.sapiens KRT8 mRNA for keratin 8 P
U76549.1 Human cytokeratin 8 mRNA, complete cds P
M77025.1 H.sapiens cytoskeletal protein mRNA PA
NM_001256293.1 Homo sapiens keratin 8 (KRT8), transcript variant 3, mRNA PA
NM_001256282.1 Homo sapiens keratin 8 (KRT8), transcript variant 1, mRNA PA
X12882.1 Human mRNA for cytokeratin 8 P
NR_045962.1 Homo sapiens keratin 8 (KRT8), transcript variant 4, non-coding RNA PA
M34225.1 Human cytokeratin 8 mRNA, complete cds P

EST sequences (10 of 2894) [Show all sequences]

AA961940.1 Clone IMAGE:1593776 kidney 3' read A
AA926859.1 Clone IMAGE:1486538 mouth 3' read A
AA995497.1 Clone IMAGE:1606078 kidney 3' read A
AA923596.1 Clone IMAGE:1534033 kidney 3' read A
AI016591.1 Clone IMAGE:1622965 embryonic tissue 3' read P
AI050030.1 Clone IMAGE:1700234 kidney 3' read A
AI061212.1 Clone IMAGE:1700370 kidney 3' read A
AI066790.1 Clone IMAGE:1637570 uncharacterized tissue 3' read A
AA506777.1 Clone DEME-25 mammary gland
AI126245.1 Clone IMAGE:1713508 placenta 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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