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UGID:1203705     UniGene Hs.529438     Homo sapiens (human)   PI4KA
Phosphatidylinositol 4-kinase, catalytic, alpha (PI4KA)

Human protein-coding gene PI4KA. Represented by 353 ESTs from 186 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 1203705 - Hs.529438]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_477352.3 PI4KA gene product H. sapiens 100.0 2101
XP_525639.3 PREDICTED: phosphatidylinositol 4-kinase alpha P. troglodytes 99.9 2097
NP_001001983.2 Pi4ka gene product M. musculus 98.5 2043
NP_001086885.2 phosphatidylinositol 4-kinase type 3 alpha X. laevis 90.8 2100
NP_001030144.1 pi4kaa gene product D. rerio 86.2 2058
NP_570014.3 phosphatidylinositol 4-kinase III alpha, isoform C D. melanogaster 63.0 1028
NP_499596.2 Protein Y75B8A.24 C. elegans 58.0 962
XP_963777.1 hypothetical protein NCU09367 N. crassa 57.7 453
NP_013408.1 1-phosphatidylinositol 4-kinase STT4 S. cerevisiae 54.7 445
XP_001700926.1 phosphatidylinositol 4-kinase C. reinhardtii 49.4 265
NP_175516.1 phosphatidylinositol 4-kinase alpha 2 A. thaliana 48.3 232
Other hits (57) [Show subset]SpeciesId(%)Len(aa)
XP_001929604.3 PREDICTED: phosphatidylinositol 4-kinase alpha S. scrofa 99.3 853
XP_002719767.1 PREDICTED: phosphatidylinositol 4-kinase type 3 alpha O. cuniculus 98.6 2043
XP_001086542.2 PREDICTED: phosphatidylinositol 4-kinase alpha M. mulatta 98.5 2085
XP_543569.4 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha C. lupus familiaris 98.3 2101
NP_071637.1 Pi4ka gene product R. norvegicus 98.2 2040
XP_003905330.1 PREDICTED: phosphatidylinositol 4-kinase alpha P. anubis 97.8 2102
XP_001915284.1 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha E. caballus 97.8 2016
NP_777002.1 PI4KA gene product B. taurus 95.8 2042
XP_003210893.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like M. gallopavo 94.7 2042
XP_003429024.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like, partial O. anatinus 94.5 163
XP_415062.3 PREDICTED: phosphatidylinositol 4-kinase alpha G. gallus 94.3 2114
XP_002195807.1 PREDICTED: phosphatidylinositol 4-kinase alpha T. guttata 94.1 2109
XP_003225157.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like isoform 1 A. carolinensis 93.8 2042
XP_003340901.1 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha-like M. domestica 93.1 2133
NP_001238804.1 phosphatidylinositol 4-kinase, catalytic, alpha X. tropicalis 91.2 2060
XP_004017731.1 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha O. aries 85.7 1745
XP_003453019.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like O. niloticus 85.5 2087
XP_004074503.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like O. latipes 85.0 2093
XP_003965399.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like T. rubripes 85.0 2085
NP_001167403.1 DNA topoisomerase 3-beta-1 S. salar 82.6 201
XP_002106004.1 GD16614 D. simulans 79.2 259
XP_002121520.1 PREDICTED: DNA topoisomerase 3-beta-1, partial C. intestinalis 68.0 122
XP_001842279.1 phosphatidylinositol 4-kinase C. quinquefasciatus 64.0 1011
XP_002736498.1 PREDICTED: phosphatidylinositol 4 kinase, putative-like S. kowalevskii 62.5 1748
XP_001952530.2 PREDICTED: phosphatidylinositol 4-kinase alpha-like A. pisum 61.7 1267
XP_002166276.1 PREDICTED: similar to predicted protein, partial H. magnipapillata 61.1 825
XP_002610260.1 hypothetical protein BRAFLDRAFT_92981 B. floridae 60.1 1963
XP_002576614.1 phosphatidylinositol 4-kinase S. mansoni 60.1 565
XP_003390739.1 PREDICTED: phosphatidylinositol 4-kinase alpha A. queenslandica 59.7 878
XP_002415623.1 phosphatidylinositol 4 kinase, putative I. scapularis 59.5 2082
XP_001634608.1 predicted protein N. vectensis 59.1 1671
XP_795613.3 PREDICTED: phosphatidylinositol 4-kinase alpha S. purpuratus 58.1 2077
XP_002842293.1 hypothetical protein T. melanosporum 58.1 395
NP_595304.1 1-phosphatidylinositol 4-kinase Stt4 (predicted) S. pombe 57.8 437
XP_969785.1 PREDICTED: similar to AGAP010801-PA T. castaneum 57.5 2079
XP_642603.2 phosphatidylinositol 4-kinase D. discoideum 57.1 324
XP_001404215.1 hypothetical protein MGG_13790 M. grisea 56.5 556
XP_773749.1 hypothetical protein CNBH2020 F. neoformans 56.0 451
XP_003397308.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like isoform 1 B. terrestris 55.9 2089
XP_623578.3 PREDICTED: phosphatidylinositol 4-kinase alpha-like isoform 2 A. mellifera 55.9 2110
XP_001658919.1 phosphatidylinositol 4-kinase A. aegypti 55.5 2057
XP_452973.1 hypothetical protein K. lactis 55.5 410
XP_318507.4 AGAP010801-PA A. gambiae 55.2 2055
XP_003068140.1 Phosphatidylinositol 3- and 4-kinase family protein C. posadasii 55.0 534
XP_003427653.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like isoform 3 N. vitripennis 54.4 2066
NP_984064.1 ADL033Wp E. gossypii 53.4 435
XP_001426253.1 hypothetical protein P. tetraurelia 52.4 267
XP_001009227.1 Phosphatidylinositol 3- and 4-kinase family protein T. thermophila 51.8 245
XP_002969873.1 hypothetical protein SELMODRAFT_92319 S. moellendorffii 51.1 307
XP_003559521.1 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha-like B. distachyon 50.9 232
XP_003631631.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like isoform 1 V. vinifera 50.2 291
XP_002313058.1 predicted protein P. trichocarpa 50.2 291
XP_002896504.1 phosphatidylinositol kinase P. infestans 50.0 180
NP_001051054.1 Os03g0711200 O. sativa 49.2 242
XP_002464002.1 hypothetical protein SORBIDRAFT_01g010410 S. bicolor 49.1 291
XP_003603887.1 Phosphatidylinositol 4-kinase M. truncatula 49.0 263
XP_003522971.1 PREDICTED: phosphatidylinositol 4-kinase alpha-like isoform 2 G. max 48.9 270

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; pancreas; uncharacterized tissue; testis; embryonic tissue; ovary; pituitary gland; uterus; placenta; stomach; thymus; lung; kidney; liver; prostate; mixed; lymph node; eye; spleen; adrenal gland; bladder; muscle; mouth; blood; heart; intestine; mammary gland; thyroid; skin; tonsil; cervix; ascites; bone; connective tissue; adipose tissue; vascular; larynx; ganglia; pineal gland; parathyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 22
Map position: 22q11.21
UniSTS entry: Chr 22 RH78571
UniSTS entry: Chr 22 RH27899
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

BC046202.2 Homo sapiens phosphatidylinositol 4-kinase, catalytic, alpha polypeptide, mRNA (cDNA clone IMAGE:6154581), partial cds A
BC053654.1 Homo sapiens phosphatidylinositol 4-kinase, catalytic, alpha, mRNA (cDNA clone IMAGE:5757080), partial cds PA
NM_002650.2 Homo sapiens phosphatidylinositol 4-kinase, catalytic, alpha (PI4KA), transcript variant 2, mRNA PA
L36151.1 Homo sapiens phosphatidylinositol 4-kinase mRNA, complete cds P
AB210002.1 Homo sapiens mRNA for PIK4CA variant protein, partial cds, clone: fg01236 P
BC018120.1 Homo sapiens phosphatidylinositol 4-kinase, catalytic, alpha, mRNA (cDNA clone IMAGE:3912560), partial cds PA
NM_058004.3 Homo sapiens phosphatidylinositol 4-kinase, catalytic, alpha (PI4KA), transcript variant 1, mRNA PA
AK314781.1 Homo sapiens cDNA, FLJ95651, highly similar to Homo sapiens phosphatidylinositol 4-kinase, catalytic, alpha polypeptide (PIK4CA), transcript variant 1, mRNA P
AK302424.1 Homo sapiens cDNA FLJ60960 complete cds, highly similar to Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) PA
AF012872.1 Homo sapiens phosphatidylinositol 4-kinase 230 (pi4K230) mRNA, complete cds PA

EST sequences (10 of 353) [Show all sequences]

R14165.1 Clone IMAGE:28309 brain 5' read
AA962545.1 Clone IMAGE:1553594 kidney 3' read A
AA974249.1 Clone IMAGE:1585939 uncharacterized tissue 3' read A
AA985083.1 Clone IMAGE:1616179 brain 3' read P
AA897726.1 Clone IMAGE:1504286 mixed 3' read A
AI017719.1 Clone IMAGE:1638601 testis 3' read A
AI027561.1 Clone IMAGE:1668849 brain 3' read A
BX110041.1 Clone IMAGp998K09144_;_IMAGE:28309 brain A
CB122046.1 Clone L8SCK0-28-B09 liver 5' read P
CB156406.1 Clone B2N807043-23-A09 brain 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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