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UGID:915025     UniGene Hs.524278     Homo sapiens (human)   GUCY2C
Guanylate cyclase 2C (heat stable enterotoxin receptor) (GUCY2C)

Human protein-coding gene GUCY2C. Represented by 43 ESTs from 26 cDNA libraries. EST representation biased toward colorectal tumor. Corresponds to reference sequence NM_004963.3. [UniGene 915025 - Hs.524278]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_004954.2 GUCY2C gene product H. sapiens 100.0 1072
NP_001120790.1 Gucy2c gene product M. musculus 86.2 1070
NP_001079334.1 guanylate cyclase 2C precursor X. laevis 70.2 1050
XP_696628.4 PREDICTED: heat-stable enterotoxin receptor-like D. rerio 61.8 1070
NP_506097.3 Protein GCY-13 C. elegans 54.8 157
NP_001033958.1 CG33958 D. melanogaster 52.4 229
XP_001692461.1 predicted protein C. reinhardtii 51.2 159
Other hits (2 of 40) [Show all]SpeciesId(%)Len(aa)
XP_528746.2 PREDICTED: heat-stable enterotoxin receptor P. troglodytes 99.4 1072
XP_001089601.1 PREDICTED: heat-stable enterotoxin receptor M. mulatta 98.0 1072

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: colorectal tumor [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: intestine; skin; testis; stomach; muscle; embryonic tissue; ascites; pancreas
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12p12
UniSTS entry: Chr 12 D12S1894 [Map Viewer]
UniSTS entry: Chr 12 STS-M73489
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (6)

M73489.1 Human heat-stable enterotoxin receptor mRNA, complete cds P
NM_004963.3 Homo sapiens guanylate cyclase 2C (heat stable enterotoxin receptor) (GUCY2C), mRNA PA
S57551.1 guanylate cyclase-coupled enterotoxin receptor [human, T84 colonic cell line, mRNA, 3787 nt] PA
AK310034.1 Homo sapiens cDNA, FLJ17076 P
BC136545.1 Homo sapiens guanylate cyclase 2C (heat stable enterotoxin receptor), mRNA (cDNA clone MGC:168158 IMAGE:9020535), complete cds P
BC136544.1 Homo sapiens guanylate cyclase 2C (heat stable enterotoxin receptor), mRNA (cDNA clone MGC:168157 IMAGE:9020534), complete cds P

EST sequences (10 of 43) [Show all sequences]

BX094688.1 Clone IMAGp998I074822_;_IMAGE:1963470 intestine A
AI262340.1 Clone IMAGE:1871082 intestine 3' read A
AI357407.1 Clone IMAGE:1963470 intestine 3' read A
AI732333.1 Clone IMAGE:924209 intestine 3' read A
AI913931.1 Clone IMAGE:2327135 intestine 3' read
BX480841.1 Clone DKFZp686H10223 muscle 5' read
BX480883.1 Clone DKFZp686J08223 muscle 5' read
BX483321.1 Clone DKFZp686N14235 muscle 5' read P
AW362865.1 intestine P
AW376840.1 intestine

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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