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UGID:912234     UniGene Hs.521487     Homo sapiens (human)   TMEM66
Transmembrane protein 66 (TMEM66)

Human protein-coding gene TMEM66. Represented by 2346 ESTs from 456 cDNA libraries. Corresponds to reference sequence NM_016127.4. [UniGene 912234 - Hs.521487]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001167715.1 PREDICTED: store-operated calcium entry-associated regulatory factor isoform 6 P. troglodytes 100.0 338
NP_057211.4 TMEM66 gene product H. sapiens 100.0 338
XP_001082934.2 PREDICTED: transmembrane protein 66 isoform 5 M. mulatta 99.7 302
NP_080708.3 Tmem66 gene product M. musculus 87.5 360
NP_001070057.1 zgc:153286 gene product D. rerio 58.8 199
NP_001090323.1 store-operated calcium entry-associated regulatory factor precursor X. laevis 55.2 298
Other hits (2 of 20) [Show all]SpeciesId(%)Len(aa)
XP_003902660.1 PREDICTED: store-operated calcium entry-associated regulatory factor P. anubis 97.1 311
XP_001494279.2 PREDICTED: transmembrane protein 66-like E. caballus 92.8 306

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; placenta; uncharacterized tissue; kidney; pancreas; lung; intestine; prostate; uterus; liver; thymus; mixed; mammary gland; embryonic tissue; stomach; blood; skin; heart; larynx; eye; spleen; parathyroid; adrenal gland; connective tissue; esophagus; pharynx; thyroid; pituitary gland; ovary; bone; trachea; cervix; muscle; mouth; bladder; vascular; pineal gland; ganglia; lymph node; bone marrow; amniotic fluid; lymph; ascites; umbilical cord; salivary gland; ear; adipose tissue; nerve; epididymis
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 8
Map position: 8p12
UniSTS entry: Chr 8 D8S2122 [Map Viewer]
UniSTS entry: Chr 8 WI-20115 [Map Viewer]
UniSTS entry: Chr 8 RH66551
UniSTS entry: Chr 8 STS-W87932
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

AF490252.1 Homo sapiens XTP3 (XTP3) mRNA, complete cds P
AK130057.1 Homo sapiens cDNA FLJ26547 fis, clone LNF00796 P
AY359104.1 Homo sapiens clone DNA96889 AAAC1967 (UNQ1967) mRNA, complete cds P
AY454545.1 Homo sapiens hypothetical protein MGC8721 isoform, partial sequence; alternatively spliced P
NM_016127.4 Homo sapiens transmembrane protein 66 (TMEM66), mRNA P
AK222632.1 Homo sapiens mRNA for hypothetical protein MGC8721 variant, clone: CBL04189 P
AK025927.1 Homo sapiens cDNA: FLJ22274 fis, clone HRC03616, highly similar to AF078855 Homo sapiens NPD003 mRNA PA
BC015012.1 Homo sapiens transmembrane protein 66, mRNA (cDNA clone MGC:8721 IMAGE:3908758), complete cds PA
AB028926.1 Homo sapiens mRNA for FOAP-7, complete cds P
AK314659.1 Homo sapiens cDNA, FLJ95506 P
AK094386.1 Homo sapiens cDNA FLJ37067 fis, clone BRACE2015262, highly similar to Transmembrane protein 66 precursor P
AK075340.1 Homo sapiens cDNA PSEC0019 fis, clone NT2RP1000125, highly similar to Transmembrane protein 66 precursor P
AF078855.1 Homo sapiens NPD003 mRNA, complete cds PA
AF100748.1 Homo sapiens HSPC035 protein mRNA, complete cds PA
Z70223.1 H.sapiens mRNA for 5'UTR for unknown protein (clone ICRFp507L0677)
AK315956.1 Homo sapiens cDNA, FLJ78855 complete cds, highly similar to Transmembrane protein 66 precursor P
AK295360.1 Homo sapiens cDNA FLJ55028 complete cds, highly similar to Transmembrane protein 66 precursor P
JQ348891.1 Homo sapiens SARAF long isoform (TMEM66) mRNA, TMEM66-L allele, complete cds, alternatively spliced PA
JQ348892.1 Homo sapiens SARAF short isoform (TMEM66) mRNA, TMEM66-S allele, complete cds, alternatively spliced P

EST sequences (10 of 2346) [Show all sequences]

AA961559.1 Clone IMAGE:1592622 kidney 3' read A
AA977285.1 Clone IMAGE:1589964 kidney 3' read A
AA987793.1 Clone IMAGE:1588835 kidney 3' read A
AA989024.1 Clone IMAGE:1602359 lung 3' read
AA909026.1 Clone IMAGE:1523186 mixed 3' read P
AI022934.1 Clone IMAGE:1651733 skin 3' read A
AI022206.1 Clone IMAGE:1654321 mixed 3' read A
AI028275.1 Clone IMAGE:1644034 testis 3' read A
AI028449.1 Clone IMAGE:1646205 parathyroid 3' read A
AI028452.1 Clone IMAGE:1646210 parathyroid 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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