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UGID:912208     UniGene Hs.521461     Homo sapiens (human)   NEFL
Neurofilament, light polypeptide (NEFL)

Human protein-coding gene NEFL. Represented by 1401 ESTs from 156 cDNA libraries. Corresponds to reference sequence NM_006158.4. [UniGene 912208 - Hs.521461]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001107100.1 PREDICTED: neurofilament light polypeptide M. mulatta 100.0 542
XP_519665.2 PREDICTED: neurofilament light polypeptide isoform 3 P. troglodytes 100.0 542
NP_006149.2 NEFL gene product H. sapiens 100.0 542
XP_003902602.1 PREDICTED: neurofilament light polypeptide P. anubis 99.8 542
XP_003639928.1 PREDICTED: neurofilament light polypeptide-like C. lupus familiaris 99.6 543
NP_035040.1 Nefl gene product M. musculus 98.7 542
NP_001081414.1 neurofilament light polypeptide X. laevis 77.4 543
NP_001034927.1 neflb gene product D. rerio 66.0 578
Other hits (2 of 19) [Show all]SpeciesId(%)Len(aa)
NP_001231260.1 NEFL gene product S. scrofa 99.3 551
XP_001914959.1 PREDICTED: neurofilament light polypeptide-like E. caballus 99.3 543

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; kidney; eye; embryonic tissue; uncharacterized tissue; nerve; ear; ganglia; lung; skin; vascular; connective tissue; esophagus; mixed; prostate; placenta; thymus; spinal cord; uterus; bone marrow; pancreas; thyroid; pineal gland; liver
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 8
Map position: 8p21
UniSTS entry: Chr 8 STS-R51365
UniSTS entry: Chr 8 RH71170
UniSTS entry: Nfl
UniSTS entry: Chr 8 WI-13419 [Map Viewer]
UniSTS entry: Chr 8 RH120868
UniSTS entry: Chr 8 GDB:181541
UniSTS entry: Chr 8 MARC_16719-16720:1018026557:1
UniSTS entry: Chr 8 Nefl
UniSTS entry: Chr 8 RH11773 [Map Viewer]
UniSTS entry: G43638
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (13)

AK127430.1 Homo sapiens cDNA FLJ45522 fis, clone BRTHA2025869, highly similar to Neurofilament triplet L protein P
NM_006158.4 Homo sapiens neurofilament, light polypeptide (NEFL), mRNA PA
BC066952.1 Homo sapiens neurofilament, light polypeptide, mRNA (cDNA clone MGC:87388 IMAGE:5264373), complete cds PA
AK225975.1 Homo sapiens mRNA for Neurofilament triplet L protein variant, clone: FCC112D04 PA
AK057731.1 Homo sapiens cDNA FLJ25002 fis, clone CBL00553, highly similar to NEUROFILAMENT TRIPLET L PROTEIN P
AK314591.1 Homo sapiens cDNA, FLJ95425 P
AL713644.1 Homo sapiens mRNA; cDNA DKFZp761K0922 (from clone DKFZp761K0922) PA
AK299095.1 Homo sapiens cDNA FLJ53642 complete cds, highly similar to Neurofilament triplet L protein P
AK075003.1 Homo sapiens cDNA FLJ90522 fis, clone NT2RP4000108, highly similar to Neurofilament triplet L protein P
AK296186.1 Homo sapiens cDNA FLJ53524 complete cds PA
BC037803.2 Homo sapiens cDNA clone IMAGE:4796752 A
BC039237.1 Homo sapiens neurofilament, light polypeptide, mRNA (cDNA clone MGC:32648 IMAGE:4280159), complete cds PA
AY156690.1 Homo sapiens light molecular weight neurofilament protein (NEFL) mRNA, complete cds P

EST sequences (10 of 1401) [Show all sequences]

R14230.1 Clone IMAGE:28422 brain 5' read
AA976892.1 Clone IMAGE:1588346 uncharacterized tissue 3' read
R16320.1 Clone IMAGE:30115 brain 5' read
AA993293.1 Clone IMAGE:1623953 embryonic tissue 3' read A
R22696.1 Clone IMAGE:31630 brain 5' read P
AI126135.1 Clone IMAGE:1735500 testis 3' read A
AI129718.1 Clone IMAGE:1712102 uterus 3' read A
BX098007.1 Clone IMAGp998M18269_;_IMAGE:44648 brain A
BX099529.1 Clone IMAGp998G115017_;_IMAGE:2038306 brain
AI266718.1 Clone IMAGE:1899711 kidney 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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