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UGID:717341     UniGene Hs.502182     Homo sapiens (human)   BDNF
Brain-derived neurotrophic factor (BDNF)

Human protein-coding gene BDNF. Represented by 65 ESTs from 35 cDNA libraries. Corresponds to 17 reference sequences (different isoforms). [UniGene 717341 - Hs.502182]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001137282.1 BDNF gene product H. sapiens 100.0 328
XP_003910154.1 PREDICTED: brain-derived neurotrophic factor P. anubis 100.0 246
NP_001012443.1 BDNF gene product P. troglodytes 100.0 246
NP_001002975.1 BDNF gene product C. lupus familiaris 99.6 246
XP_002709071.1 PREDICTED: brain-derived neurotrophic factor-like O. cuniculus 99.6 246
NP_031566.4 Bdnf gene product M. musculus 98.4 256
NP_001078951.1 brain-derived neurotrophic factor precursor X. laevis 91.1 246
NP_571670.2 bdnf gene product D. rerio 82.2 269
Other hits (2 of 16) [Show all]SpeciesId(%)Len(aa)
XP_001089568.2 PREDICTED: brain-derived neurotrophic factor M. mulatta 99.4 328
NP_999424.1 BDNF gene product S. scrofa 98.4 251

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; mixed; liver; connective tissue; uncharacterized tissue; thyroid; eye; lung; embryonic tissue; skin; prostate; heart; uterus; adrenal gland; testis
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11p13
UniSTS entry: Chr 11 D11S4429
UniSTS entry: Chr 11 BDNF-1
UniSTS entry: Chr 11 BDNF
UniSTS entry: Chr 11 BDNF_2411
UniSTS entry: Chr 11 GDB:197571
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (60)

NM_001709.4 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 4, mRNA P
AY442188.1 Homo sapiens brain-derived neurotrophic factor isoform 1 (BDNF) mRNA, partial cds, alternatively spliced
AY656701.1 Homo sapiens brain-derived neurotrophic factor transcript variant 5 mRNA, complete cds P
X91251.1 H.sapiens mRNA for BDNF protein P
X60201.1 Human mRNA for brain-derived neurotrophic factor P
DQ250642.1 Homo sapiens brain-derived neurotrophic factor preproprotein isoform 2 (BDNF) mRNA, partial cds
AF400438.1 Homo sapiens brain-derived neurotrophic factor (BDNF) mRNA, complete cds P
EF674521.1 Homo sapiens brain derived neurotrophic factor transcript IV (BDNF) mRNA, complete cds, alternatively spliced P
EF674520.1 Homo sapiens brain derived neurotrophic factor transcript III (BDNF) mRNA, complete cds, alternatively spliced P
EF674519.1 Homo sapiens brain derived neurotrophic factor transcript IIc (BDNF) mRNA, complete cds, alternatively spliced P
EF674518.1 Homo sapiens brain derived neurotrophic factor transcript IIb (BDNF) mRNA, complete cds, alternatively spliced P
EF674517.1 Homo sapiens brain derived neurotrophic factor transcript IIa (BDNF) mRNA, complete cds, alternatively spliced P
EF689021.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689020.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689019.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689018.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689017.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689016.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689015.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689014.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689013.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689012.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689011.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689010.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
EF689009.1 Homo sapiens brain derived neurotrophic factor variant (BDNF) mRNA, complete cds P
AK289853.1 Homo sapiens cDNA FLJ77015 complete cds, highly similar to Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 3, mRNA P
AK289763.1 Homo sapiens cDNA FLJ77010 complete cds, highly similar to Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 4, mRNA P
BC029795.1 Homo sapiens brain-derived neurotrophic factor, mRNA (cDNA clone MGC:34632 IMAGE:5193877), complete cds PA
AB038674.1 Homo sapiens BDNF 4I-5 mRNA for brain-derived neurotrophic factor, partial cds
AB038673.1 Homo sapiens BDNF 4-5 mRNA for brain-derived neurotrophic factor, partial cds
AB038672.1 Homo sapiens BDNF 3-5 mRNA for brain-derived neurotrophic factor, partial cds
AB038671.1 Homo sapiens BDNF 2-5 mRNA for brain-derived neurotrophic factor, partial cds
AB038670.1 Homo sapiens BDNF 1-5 mRNA for brain-derived neurotrophic factor, partial cds
NM_001143816.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 16, mRNA P
NM_001143814.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 14, mRNA P
NM_001143813.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 13, mRNA P
NM_001143812.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 12, mRNA P
NM_001143811.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 11, mRNA P
NM_001143810.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 18, mRNA P
NM_001143809.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 17, mRNA P
NM_001143808.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 10, mRNA P
NM_001143807.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 9, mRNA P
NM_001143806.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 8, mRNA P
NM_001143805.1 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 7, mRNA P
M61176.1 Homo sapiens brain-derived neurotrophic factor precursor (BDNF) mRNA, complete cds P
NM_170735.5 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 1, mRNA P
NM_170734.3 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 6, mRNA P
NM_170733.3 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 5, mRNA P
NM_170732.4 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 2, mRNA P
NM_170731.4 Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 3, mRNA P
AY054406.3 Homo sapiens brain-derived neurotrophic factor BDNF7 (BDNF) mRNA, complete cds, alternatively spliced PA
AY054400.2 Homo sapiens brain-derived neurotrophic factor BDNF6B (BDNF) mRNA, complete cds, alternatively spliced PA
AY054399.2 Homo sapiens brain-derived neurotrophic factor BDNF6A (BDNF) mRNA, complete cds, alternatively spliced PA
AY054398.2 Homo sapiens brain-derived neurotrophic factor BDNF5 (BDNF) mRNA, complete cds, alternatively spliced PA
AY054397.2 Homo sapiens brain-derived neurotrophic factor BDNF4 (BDNF) mRNA, complete cds, alternatively spliced PA
AY054396.2 Homo sapiens brain-derived neurotrophic factor BDNF3 (BDNF) mRNA, complete cds, alternatively spliced PA
AY054395.2 Homo sapiens brain-derived neurotrophic factor BDNF2C (BDNF) mRNA, complete cds, alternatively spliced PA
AY054394.2 Homo sapiens brain-derived neurotrophic factor BDNF2B (BDNF) mRNA, complete cds, alternatively spliced PA
AY054393.2 Homo sapiens brain-derived neurotrophic factor BDNF2A (BDNF) mRNA, complete cds, alternatively spliced PA
AY054392.2 Homo sapiens brain-derived neurotrophic factor BDNF1 (BDNF) mRNA, complete cds, alternatively spliced PA

EST sequences (10 of 65) [Show all sequences]

AI086251.1 Clone IMAGE:1656069 mixed 3' read A
AI127530.1 Clone IMAGE:1711124 uterus 3' read A
AI086584.1 Clone IMAGE:1681243 skin 3' read
AA905721.1 Clone IMAGE:1506098 mixed 3' read A
AI242172.1 Clone IMAGE:1851120 mixed 3' read
AI339280.1 Clone IMAGE:1946287 uncharacterized tissue 3' read P
AI457725.1 Clone IMAGE:2147538 mixed 3' read A
AI399831.1 Clone IMAGE:2113983 mixed 3' read A
AI655563.1 Clone IMAGE:2242038 uncharacterized tissue 3' read
AI655574.1 Clone IMAGE:2242039 uncharacterized tissue 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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