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UGID:716791     UniGene Hs.501632     Homo sapiens (human)   CACNA1A
Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A)

Human protein-coding gene CACNA1A. Represented by 65 ESTs from 42 cDNA libraries. EST representation biased toward infant. Corresponds to 5 reference sequences (different isoforms). [UniGene 716791 - Hs.501632]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_075461.2 CACNA1A gene product H. sapiens 100.0 2511
NP_031604.3 Cacna1a gene product M. musculus 94.7 2367
XP_698014.5 PREDICTED: voltage-dependent P/Q-type calcium channel subunit alpha-1A D. rerio 79.0 2338
NP_996419.1 cacophony, isoform C D. melanogaster 60.8 1773
NP_741733.1 Protein UNC-2, isoform c C. elegans 56.2 1885
Other hits (2 of 38) [Show all]SpeciesId(%)Len(aa)
XP_003123391.3 PREDICTED: voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 1 S. scrofa 98.4 1847
XP_003432961.1 PREDICTED: voltage-dependent P/Q-type calcium channel subunit alpha-1A C. lupus familiaris 98.0 2261

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: infant [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; eye; embryonic tissue; mixed; pancreas; uterus; muscle; uncharacterized tissue; lung; testis; ovary; kidney; skin; blood; tonsil; lymph node
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19p13
UniSTS entry: Chr 19 G54424
UniSTS entry: Chr 19 G54394
UniSTS entry: Chr 19 G54374
UniSTS entry: Chr 19 G54417
UniSTS entry: Chr 19 G54416
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (22)

AF100774.1 Homo sapiens voltage-dependent P/Q type calcium channel alpha 1A subunit (CACNA1A) mRNA, partial cds P
NM_000068.3 Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 1, mRNA PA
AB035727.2 Homo sapiens CACNA1A mRNA for alpha1A-voltage-dependent calcium channel, complete cds, isolate:TMDN-CNT-001 P
NM_023035.2 Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 2, mRNA PA
NM_001127222.1 Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 4, mRNA PA
NM_001127221.1 Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 3, mRNA PA
EU016197.1 Homo sapiens fetal brain Ca2+ voltage-gated channel alpha1A pore-forming subunit (CACNA1A) mRNA, partial cds P
FJ040507.1 Homo sapiens neuronal calcium channel alpha 1a subunit Cav 2.1 (CACNA1A) mRNA, complete cds P
BC028611.1 Homo sapiens cDNA clone IMAGE:4795326 A
AB035726.1 Homo sapiens CACNA1A mRNA for alpha1A-voltage-dependent calcium channel, partial cds, isolate:TMDN-SCA6-001 P
S76537.1 P-type voltage-gated calcium channel alpha 1 subunit homolog [human, H146 small-cell lung carcinoma cells, mRNA Partial, 345 nt] P
U06702.1 Human clone CCA54 mRNA containing CCA trinucleotide repeat P
X99897.1 H.sapiens mRNA for P/Q-type calcium channel alpha1 subunit P
NM_001174080.1 Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 5, mRNA PA
U79663.1 Human alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1, partial cds P
U79664.1 Human alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1 (V1), partial cds P
U79665.1 Human alpha1A-voltage-sensitive calcium channel mRNA, splice form BI-1-GGCAG, partial cds P
U79666.1 Homo sapiens alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1-Vi-GGCAG, complete cds P
U79667.1 Human alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1-V2-GGCAG, partial cds P
U79668.1 Human alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1-V2,V3, partial cds P
AF004883.1 Homo sapiens neuronal calcium channel alpha 1A subunit isoform 1A-2 mRNA, complete cds P
AF004884.1 Homo sapiens neuronal calcium channel alpha 1A subunit isoform A-1 mRNA, complete cds P

EST sequences (10 of 65) [Show all sequences]

AA902687.1 Clone IMAGE:1521662 lung 3' read A
AI086488.1 Clone IMAGE:1679696 skin 3' read P
AI244450.1 Clone IMAGE:1866445 kidney 3' read
AA769818.1 Clone 1321997 testis 3' read A
AI379370.1 Clone IMAGE:2060385 brain 3' read
AI570485.1 Clone IMAGE:2164119 brain 3' read P
AI590622.1 Clone IMAGE:2260622 ovary 3' read P
AI651113.1 Clone IMAGE:2304117 uncharacterized tissue 3' read
BX281708.1 Clone IMAGp998F155596_;_IMAGE:2260622 ovary
AI932384.1 Clone IMAGE:2329400 mixed 3' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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