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UGID:715705     UniGene Hs.500546     Homo sapiens (human)   IDE
Insulin-degrading enzyme (IDE)

Human protein-coding gene IDE. Represented by 370 ESTs from 191 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 715705 - Hs.500546]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_507922.2 PREDICTED: insulin-degrading enzyme isoform 4 P. troglodytes 100.0 1018
NP_004960.2 IDE gene product H. sapiens 100.0 1018
XP_001090249.1 PREDICTED: insulin-degrading enzyme isoform 3 M. mulatta 99.8 1018
XP_003904048.1 PREDICTED: insulin-degrading enzyme, partial P. anubis 99.8 1005
XP_004020338.1 PREDICTED: insulin-degrading enzyme O. aries 99.7 999
NP_001069317.1 IDE gene product B. taurus 99.6 1018
XP_001501085.2 PREDICTED: insulin-degrading enzyme E. caballus 99.5 1018
NP_112419.2 Ide gene product M. musculus 97.6 1018
NP_001082994.1 ide gene product D. rerio 92.3 977
XP_001695185.1 insulinase-like metalloprotease C. reinhardtii 57.0 228
NP_524182.3 insulin degrading metalloproteinase D. melanogaster 53.0 959
NP_504531.2 Protein C02G6.2 C. elegans 52.7 548
NP_013493.2 Ste23p S. cerevisiae 52.1 545
XP_956166.1 hypothetical protein NCU00481 N. crassa 52.0 323
NP_567049.3 insulysin A. thaliana 49.6 278
Other hits (2 of 53) [Show all]SpeciesId(%)Len(aa)
XP_534963.3 PREDICTED: LOW QUALITY PROTEIN: insulin-degrading enzyme C. lupus familiaris 99.4 1024
XP_001925416.3 PREDICTED: insulin-degrading enzyme isoform 1 S. scrofa 99.4 1018

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: testis; uterus; skin; brain; mixed; vascular; embryonic tissue; connective tissue; placenta; eye; adrenal gland; trachea; intestine; ovary; bone marrow; blood; esophagus; lymph node; uncharacterized tissue; liver; lung; kidney; mammary gland; muscle; larynx; prostate; heart; pancreas; bone; stomach; spinal cord; parathyroid; thymus; ascites; pituitary gland; cervix; tonsil
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10q23-q25
UniSTS entry: Chr 10 STS-D29519
UniSTS entry: Chr 10 WI-17525 [Map Viewer]
UniSTS entry: Chr 10 GDB:193867
UniSTS entry: Chr 10 IDE
UniSTS entry: Ide
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (14)

BX648462.1 Homo sapiens mRNA; cDNA DKFZp781M0420 (from clone DKFZp781M0420) PA
NM_004969.3 Homo sapiens insulin-degrading enzyme (IDE), transcript variant 1, mRNA P
M21188.1 Human insulin-degrading enzyme (IDE) mRNA, complete cds P
AB209204.1 Homo sapiens mRNA for insulysin variant protein P
BC096338.1 Homo sapiens cDNA clone IMAGE:40008466, containing frame-shift errors P
BC096336.1 Homo sapiens insulin-degrading enzyme, mRNA (cDNA clone MGC:117026 IMAGE:40008464), complete cds P
BC096339.3 Homo sapiens insulin-degrading enzyme, mRNA (cDNA clone MGC:117029 IMAGE:40008468), complete cds P
BC096337.1 Homo sapiens insulin-degrading enzyme, mRNA (cDNA clone MGC:117027 IMAGE:40008465), complete cds P
AK312810.1 Homo sapiens cDNA, FLJ93240, highly similar to Homo sapiens insulin-degrading enzyme (IDE), mRNA P
AK093287.1 Homo sapiens cDNA FLJ35968 fis, clone TESTI2013053, highly similar to INSULIN-DEGRADING ENZYME (EC 3.4.24.56) P
AK316407.1 Homo sapiens cDNA, FLJ79306 complete cds, highly similar to Insulin-degrading enzyme (EC 3.4.24.56) P
AK302578.1 Homo sapiens cDNA FLJ53247 complete cds, highly similar to Insulin-degrading enzyme (EC 3.4.24.56) P
NM_001165946.1 Homo sapiens insulin-degrading enzyme (IDE), transcript variant 2, mRNA P
BC036188.1 Homo sapiens cDNA clone IMAGE:4825971, containing frame-shift errors PA

EST sequences (10 of 370) [Show all sequences]

AA978052.1 Clone IMAGE:1590306 kidney 3' read
AA909059.1 Clone IMAGE:1540817 mixed 3' read P
AI017759.1 Clone IMAGE:1638985 testis 3' read P
AI076258.1 Clone IMAGE:1672787 mixed 3' read P
AI125862.1 Clone IMAGE:1737752 testis 3' read PA
AI141765.1 Clone IMAGE:1690731 mixed 3' read
CB117766.1 Clone L4SNU368-32-E08 liver 5' read
CB112462.1 Clone L6ChoCK0-3-G01 liver 5' read
AI241500.1 Clone IMAGE:1849939 mixed 3' read P
AI394289.1 Clone IMAGE:2108289 uncharacterized tissue 3' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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