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UGID:713451     UniGene Hs.498292     Homo sapiens (human)   AKT3
V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3)

Human protein-coding gene AKT3. Represented by 467 ESTs from 194 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 713451 - Hs.498292]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_035915.3 Akt3 gene product M. musculus 100.0 478
XP_002189920.1 PREDICTED: RAC-gamma serine/threonine-protein kinase isoform 1 T. guttata 100.0 478
XP_419544.1 PREDICTED: RAC-gamma serine/threonine-protein kinase G. gallus 100.0 478
XP_003204029.1 PREDICTED: RAC-gamma serine/threonine-protein kinase-like M. gallopavo 100.0 478
XP_001104624.2 PREDICTED: RAC-gamma serine/threonine-protein kinase M. mulatta 100.0 478
XP_003308887.1 PREDICTED: RAC-gamma serine/threonine-protein kinase-like isoform 1 P. troglodytes 100.0 478
NP_005456.1 AKT3 gene product H. sapiens 100.0 478
XP_547496.2 PREDICTED: RAC-gamma serine/threonine-protein kinase isoform 1 C. lupus familiaris 100.0 478
XP_001492015.1 PREDICTED: RAC-gamma serine/threonine-protein kinase isoform 1 E. caballus 100.0 478
NP_001243075.1 RAC-gamma serine/threonine-protein kinase S. scrofa 100.0 478
NP_001178238.1 RAC-gamma serine/threonine-protein kinase B. taurus 100.0 478
XP_004013704.1 PREDICTED: RAC-gamma serine/threonine-protein kinase isoform 1 O. aries 100.0 478
XP_002717694.1 PREDICTED: AKT3 kinase O. cuniculus 100.0 478
NP_113763.1 Akt3 gene product R. norvegicus 100.0 452
XP_001377681.2 PREDICTED: RAC-gamma serine/threonine-protein kinase M. domestica 99.8 476
XP_001513899.2 PREDICTED: RAC-gamma serine/threonine-protein kinase-like O. anatinus 99.8 441
NP_001184130.1 akt3a gene product D. rerio 97.9 478
NP_001083878.1 RAC-alpha serine/threonine-protein kinase X. laevis 90.2 479
NP_732114.1 Akt1, isoform A D. melanogaster 73.5 502
NP_001023646.1 Protein AKT-1, isoform b C. elegans 65.8 508
NP_012796.1 Ypk1p S. cerevisiae 53.0 330
XP_962134.2 serine/threonine-protein kinase gad8 N. crassa 51.2 324
XP_001693559.1 ribosomal protein S6 kinase C. reinhardtii 46.7 257
Other hits (2 of 53) [Show all]SpeciesId(%)Len(aa)
XP_004077103.1 PREDICTED: RAC-gamma serine/threonine-protein kinase-like O. latipes 97.1 478
XP_003972238.1 PREDICTED: RAC-gamma serine/threonine-protein kinase-like T. rubripes 96.0 478

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; eye; mammary gland; pancreas; connective tissue; lung; prostate; thyroid; embryonic tissue; testis; mixed; vascular; nerve; thymus; stomach; skin; bladder; ovary; ear; uterus; uncharacterized tissue; placenta; intestine; muscle; adrenal gland; kidney; lymph node; heart; parathyroid; bone; trachea; liver; pituitary gland; ganglia; cervix; adipose tissue; blood; pineal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 1
Map position: 1q44
UniSTS entry: Chr 1 SHGC-76620
UniSTS entry: Chr 1 RH12417
UniSTS entry: Chr 1 G27428
UniSTS entry: Chr 1 SHGC-146222
UniSTS entry: Chr 1 RH64659
UniSTS entry: Chr 1 SHGC-76607 [Map Viewer]
UniSTS entry: Chr 1 SHGC-76615
UniSTS entry: Chr 1 SHGC-76617 [Map Viewer]
UniSTS entry: Chr 1 AKT3_697
UniSTS entry: MARC_17674-17675:1030546305:1
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (16)

NM_181690.2 Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3), transcript variant 2, mRNA P
AJ245709.1 Homo sapiens mRNA for serine/threonine kinase Akt-3 (Akt3 gene) P
AL117525.1 Homo sapiens mRNA; cDNA DKFZp434N0250 (from clone DKFZp434N0250) PA
NM_005465.4 Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3), transcript variant 1, mRNA PA
AF135794.1 Homo sapiens AKT3 protein kinase mRNA, complete cds PA
AF124141.1 Homo sapiens protein kinase B gamma mRNA, complete cds P
BC121154.2 Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma), mRNA (cDNA clone MGC:150492 IMAGE:40121374), complete cds P
AY005799.1 Homo sapiens protein kinase B gamma 1 (AKT3) mRNA, complete cds, alternatively spliced P
AK055109.1 Homo sapiens cDNA FLJ30547 fis, clone BRAWH2001439
AF085234.1 Homo sapiens STK-2 mRNA, complete cds P
BC019085.2 Homo sapiens cDNA clone IMAGE:4870417, partial cds A
AK308052.1 Homo sapiens cDNA, FLJ98000 P
BC020479.1 Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma), mRNA (cDNA clone IMAGE:3867931), partial cds P
AL080074.1 Homo sapiens mRNA; cDNA DKFZp564B0262 (from clone DKFZp564B0262) A
U79271.1 Human clones 23920 and 23921 mRNA sequence
NM_001206729.1 Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3), transcript variant 3, mRNA PA

EST sequences (10 of 467) [Show all sequences]

AA971254.1 Clone IMAGE:1582478 mixed 3' read A
AA975268.1 Clone IMAGE:1558857 lung 3' read A
AA977504.1 Clone IMAGE:1561075 mixed 3' read A
R14906.1 Clone IMAGE:30110 brain 5' read
AI028416.1 Clone IMAGE:1649599 parathyroid 3' read A
AI033069.1 Clone IMAGE:1654395 mixed 3' read A
AI038590.1 Clone IMAGE:1658236 embryonic tissue 3' read A
R20180.1 Clone IMAGE:34539 brain 5' read
AI057361.1 Clone IMAGE:1674578 mixed 3' read
AI074114.1 Clone IMAGE:1679127 skin 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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