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UGID:710833     UniGene Hs.495674     Homo sapiens (human)   CLCN4
Chloride channel, voltage-sensitive 4 (CLCN4)

Human protein-coding gene CLCN4. Represented by 290 ESTs from 97 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 710833 - Hs.495674]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003917441.1 PREDICTED: H(+)/Cl(-) exchange transporter 4 isoform 1 P. anubis 100.0 759
NP_001821.2 CLCN4 gene product H. sapiens 100.0 759
XP_848379.1 PREDICTED: H(+)/Cl(-) exchange transporter 4 isoform 2 C. lupus familiaris 99.6 759
XP_001488071.1 PREDICTED: H(+)/Cl(-) exchange transporter 4 E. caballus 99.6 759
NP_071534.2 Clcn4 gene product R. norvegicus 99.6 753
NP_035464.3 Clcn4-2 gene product M. musculus 99.2 746
NP_001070786.1 zgc:153764 gene product D. rerio 93.1 767
NP_001083736.1 chloride channel, voltage-sensitive 3 X. laevis 82.3 761
NP_648834.1 chloride channel-c, isoform B D. melanogaster 68.4 749
NP_495940.1 Protein CLH-5 C. elegans 60.3 775
XP_957335.2 hypothetical protein NCU06444 N. crassa 54.8 343
NP_012574.1 Gef1p S. cerevisiae 47.8 180
Other hits (2 of 40) [Show all]SpeciesId(%)Len(aa)
XP_001925262.3 PREDICTED: LOW QUALITY PROTEIN: H(+)/Cl(-) exchange transporter 4-like S. scrofa 99.2 759
XP_001381161.1 PREDICTED: H(+)/Cl(-) exchange transporter 4 M. domestica 99.1 759

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; eye; testis; pituitary gland; thyroid; vascular; liver; uncharacterized tissue; embryonic tissue; pancreas; kidney; lymph node; muscle; mixed; mammary gland; pineal gland; ovary; lung; parathyroid; skin; heart; connective tissue; larynx
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: X
Map position: Xp22.3
UniSTS entry: Chr X STS-AA018252 [Map Viewer]
UniSTS entry: Chr X CLCN4
UniSTS entry: Chr X A004U24 [Map Viewer]
UniSTS entry: Chr X G20389
UniSTS entry: Chr X A005P03 [Map Viewer]
UniSTS entry: Chr X STS-X77197 [Map Viewer]
UniSTS entry: Chr X A008T30 [Map Viewer]
UniSTS entry: Chr X CLCN4_3951
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

AF052117.1 Homo sapiens clone 23809 mRNA sequence A
AB019432.1 Homo sapiens mRNA for chloride channel protein 4, complete cds P
NM_001830.3 Homo sapiens chloride channel, voltage-sensitive 4 (CLCN4), transcript variant 1, mRNA P
AF170492.1 Homo sapiens chloride channel CLC4 (ClC4) mRNA, complete cds P
AK225287.1 Homo sapiens mRNA for Chloride channel protein 4 variant, clone: HEP00583 PA
BC130278.1 Homo sapiens chloride channel 4, mRNA (cDNA clone MGC:163150 IMAGE:40146309), complete cds P
AK289564.1 Homo sapiens cDNA FLJ75572 complete cds, highly similar to Homo sapiens chloride channel 4 (CLCN4), mRNA P
AK299611.1 Homo sapiens cDNA FLJ50190 complete cds, highly similar to Chloride channel protein 4 P
BC036068.1 Homo sapiens chloride channel 4, mRNA (cDNA clone MGC:33700 IMAGE:5311366), complete cds PA
X77197.1 H.sapiens mRNA for chloride channel PA
NM_001256944.1 Homo sapiens chloride channel, voltage-sensitive 4 (CLCN4), transcript variant 2, mRNA PA

EST sequences (10 of 290) [Show all sequences]

AI073800.1 Clone IMAGE:1671076 uncharacterized tissue 3' read P
AI124785.1 Clone IMAGE:1539535 brain 3' read P
AI087050.1 Clone IMAGE:1671168 uncharacterized tissue 3' read P
AI146752.1 Clone IMAGE:1672497 uncharacterized tissue 3' read P
BX116599.1 Clone IMAGp998B21888_;_IMAGE:383156 pineal gland
BX099704.1 Clone IMAGp998H1974_;_IMAGE:23809 brain A
AI168107.1 Clone IMAGE:1682717 parathyroid 3' read
AA947852.1 Clone IMAGE:1508481 mixed 3' read P
AI305163.1 Clone IMAGE:1879078 mixed 3' read
R39536.1 Clone IMAGE:23809 brain 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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