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UGID:710632     UniGene Hs.495473     Homo sapiens (human)   NOTCH1
Notch 1 (NOTCH1)

Human protein-coding gene NOTCH1. Represented by 240 ESTs from 112 cDNA libraries. Corresponds to reference sequence NM_017617.3. [UniGene 710632 - Hs.495473]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_060087.3 NOTCH1 gene product H. sapiens 100.0 2554
XP_520371.2 PREDICTED: neurogenic locus notch homolog protein 1 isoform 2 P. troglodytes 99.9 2554
NP_032740.3 Notch1 gene product M. musculus 94.0 2530
NP_001081074.1 neurogenic locus notch protein homolog precursor X. laevis 80.1 2518
NP_571516.1 notch1a gene product D. rerio 74.4 2420
NP_476859.2 notch, isoform A D. melanogaster 52.9 2279
Other hits (2 of 39) [Show all]SpeciesId(%)Len(aa)
XP_003911159.1 PREDICTED: neurogenic locus notch homolog protein 1, partial P. anubis 99.0 2511
XP_002808138.1 PREDICTED: LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1-like M. mulatta 98.0 2462

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; lymph node; uncharacterized tissue; embryonic tissue; mammary gland; eye; lung; intestine; uterus; mixed; testis; pancreas; esophagus; adipose tissue; blood; heart; mouth; placenta; stomach; skin; vascular; thymus; trachea; muscle; thyroid; connective tissue; ovary; kidney; prostate; liver; bone marrow; bone
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 9
Map position: 9q34.3
UniSTS entry: Chr 9 RH80945
UniSTS entry: Chr 9 PMC85812P1
UniSTS entry: Chr 9 STS-M73980
UniSTS entry: Chr 9 PMC122602P2
UniSTS entry: Chr 9 PMC140667P1
UniSTS entry: D19S235E
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

BC046127.1 Homo sapiens, clone IMAGE:4938771, mRNA A
BC049843.1 Homo sapiens Notch homolog 1, translocation-associated (Drosophila), mRNA (cDNA clone IMAGE:4448593), with apparent retained intron A
BC063597.1 Homo sapiens cDNA clone IMAGE:4754960, partial cds A
AK000012.1 Homo sapiens cDNA FLJ20005 fis, clone ADKA02526 A
CR457221.1 Homo sapiens full open reading frame cDNA clone RZPDo834G108D for gene NOTCH1, Notch homolog 1, translocation-associated (Drosophila); complete cds, incl. stopcodon
NM_017617.3 Homo sapiens notch 1 (NOTCH1), mRNA PA
AB209873.1 Homo sapiens mRNA for notch1 preproprotein variant protein P
AF308602.1 Homo sapiens NOTCH 1 (N1) mRNA, complete cds P
BC013208.1 Homo sapiens Notch homolog 1, translocation-associated (Drosophila), mRNA (cDNA clone IMAGE:4156263) PA
M73980.1 Human TAN-1 mRNA (homologue of Drosophila Notch gene), 5' end P
BC039147.1 Homo sapiens Notch homolog 1, translocation-associated (Drosophila), mRNA (cDNA clone IMAGE:4746828), with apparent retained intron A

EST sequences (10 of 240) [Show all sequences]

R14458.1 Clone IMAGE:28941 brain 5' read
AA903201.1 Clone IMAGE:1517212 uncharacterized tissue 3' read A
AA983847.1 Clone IMAGE:1581450 mixed 3' read
R16356.1 Clone IMAGE:29710 brain 5' read
AA993959.1 Clone IMAGE:1628148 mixed 3' read
AA910223.1 Clone IMAGE:1493614 kidney 3' read P
AI089878.1 Clone IMAGE:1686479 brain 3' read A
AI097223.1 Clone IMAGE:1707173 heart 3' read A
AA864921.1 Clone IMAGE:1469527 uncharacterized tissue 3' read A
AI192552.1 Clone IMAGE:1743936 lung 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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