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UGID:137773     UniGene Hs.49063     Homo sapiens (human)   ERCC6
Excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6)

Human protein-coding gene ERCC6. Represented by 122 ESTs from 83 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 137773 - Hs.49063]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000115.1 ERCC6 gene product H. sapiens 100.0 1492
XP_003954270.1 PREDICTED: DNA excision repair protein ERCC-6 P. troglodytes 99.8 862
NP_001074690.1 DNA excision repair protein ERCC-6 M. musculus 84.9 1480
XP_688972.2 PREDICTED: DNA excision repair protein ERCC-6 D. rerio 71.7 1335
XP_001696221.1 SNF2/RAD54 family protein C. reinhardtii 56.6 548
NP_012569.1 Rad26p S. cerevisiae 54.9 667
XP_962958.1 hypothetical protein NCU07837 N. crassa 52.8 561
NP_179466.1 DNA excision repair protein E A. thaliana 52.5 659
Other hits (2 of 55) [Show all]SpeciesId(%)Len(aa)
XP_001107536.1 PREDICTED: DNA excision repair protein ERCC-6 M. mulatta 98.5 1495
XP_003903675.1 PREDICTED: DNA excision repair protein ERCC-6 P. anubis 98.4 1493

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; skin; muscle; embryonic tissue; uterus; kidney; mammary gland; uncharacterized tissue; mixed; liver; intestine; stomach; mouth; lung; eye; placenta; vascular; heart; esophagus; trachea; bladder; connective tissue; blood; ear; ascites; bone; lymph node; prostate
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10q11.23
UniSTS entry: Chr 10 RH92205
UniSTS entry: Chr 10 RH26695
UniSTS entry: Chr 10 RH104261
UniSTS entry: Chr 10 STS-L04791 [Map Viewer]
UniSTS entry: Chr 10 D10S1553
UniSTS entry: Chr 10 RH44808 [Map Viewer]
UniSTS entry: Chr 10 D10S1378E
UniSTS entry: Chr 10 ERCC6_1944
UniSTS entry: Chr 10 SHGC-37683 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (14)

AK130100.1 Homo sapiens cDNA FLJ26590 fis, clone LNF07869, highly similar to Excision repair protein ERCC-6 P
NM_000124.3 Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6), mRNA PA
BC063690.1 Homo sapiens piggyBac transposable element derived 3, mRNA (cDNA clone MGC:70395 IMAGE:4450811), complete cds PA
AL133084.1 Homo sapiens mRNA; cDNA DKFZp434J1027 (from clone DKFZp434J1027) PA
L04791.1 Human excision repair protein ERCC6 mRNA, complete cds P
CR749388.1 Homo sapiens mRNA; cDNA DKFZp781P1019 (from clone DKFZp781P1019) PA
BC127104.1 Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 6, mRNA (cDNA clone MGC:150685 IMAGE:40124639), complete cds P
BC028954.1 Homo sapiens piggyBac transposable element derived 3, mRNA (cDNA clone MGC:30025 IMAGE:4479639), complete cds PA
AK094670.1 Homo sapiens cDNA FLJ37351 fis, clone BRAMY2021867
AK303022.1 Homo sapiens cDNA FLJ57242 complete cds, highly similar to DNA excision repair protein ERCC-6 (EC 3.6.1.-) P
AK074682.1 Homo sapiens cDNA FLJ90201 fis, clone MAMMA1001623, weakly similar to Homo sapiens piggyBac transposable element derived 1 (PGBD1), mRNA P
NM_001277059.1 Homo sapiens Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3), transcript variant 2, mRNA
NM_001277058.1 Homo sapiens Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3), transcript variant 1, mRNA
NM_170753.3 Homo sapiens piggyBac transposable element derived 3 (PGBD3), mRNA P

EST sequences (10 of 122) [Show all sequences]

R20166.1 Clone IMAGE:34326 brain 5' read
AI150981.1 Clone IMAGE:1704927 heart 3' read A
BX100994.1 Clone IMAGp998A16158_;_IMAGE:34326 brain A
BX115797.1 Clone IMAGp998P202899_;_IMAGE:1155715 kidney A
BX091213.1 Clone IMAGp998H14631_;_IMAGE:284605 brain
BX091366.1 Clone IMAGp998K041814_;_IMAGE:738939 mixed A
BX091642.1 Clone IMAGp998L124568_;_IMAGE:1866011 kidney
AI190818.1 Clone IMAGE:1732924 heart 3' read
AI261278.1 Clone IMAGE:2028565 kidney 3' read A
CB111847.1 Clone L5HLK1-22-D03 liver 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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