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UGID:691376     UniGene Hs.476217     Homo sapiens (human)   PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4)

Human protein-coding gene PFKFB4. Represented by 200 ESTs from 85 cDNA libraries. Corresponds to reference sequence NM_004567.2. [UniGene 691376 - Hs.476217]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003309835.1 PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 P. troglodytes 100.0 497
NP_004558.1 PFKFB4 gene product H. sapiens 100.0 468
XP_002713422.1 PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4-like O. cuniculus 100.0 468
XP_001926203.1 PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 isoform 1 S. scrofa 99.8 468
XP_001499076.1 PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 isoform 1 E. caballus 99.6 468
NP_766607.3 Pfkfb4 gene product M. musculus 98.3 468
NP_001084943.1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 X. laevis 88.2 466
NP_942111.1 pfkfb4l gene product D. rerio 87.8 468
NP_728249.1 6-phosphofructo-2-kinase, isoform A D. melanogaster 63.2 446
NP_491529.2 Protein Y110A7A.6, isoform a C. elegans 60.6 438
XP_958926.1 fructose-2,6-bisphosphatase N. crassa 54.7 435
NP_012380.1 Fbp26p S. cerevisiae 54.3 409
XP_001698836.1 hypothetical protein CHLREDRAFT_121054 C. reinhardtii 50.4 392
NP_172191.1 fructose-2,6-bisphosphatase A. thaliana 48.2 398
Other hits (2 of 55) [Show all]SpeciesId(%)Len(aa)
XP_541893.2 PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 isoform 3 C. lupus familiaris 99.4 468
NP_001179764.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 B. taurus 99.4 468

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: testis; brain; skin; placenta; uncharacterized tissue; intestine; uterus; embryonic tissue; lung; blood; muscle; mixed; kidney; mouth; liver; eye; connective tissue; bladder; spleen; thymus; trachea; bone marrow; ovary; larynx; nerve; pancreas
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 3
Map position: 3p22-p21
UniSTS entry: Chr 3 RH94072
UniSTS entry: Chr 3 RH80762
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

AF108765.1 Homo sapiens testis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFKFB4) mRNA, complete cds PA
NM_004567.2 Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), mRNA PA
AY707863.1 Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 isoform 1 (PFKFB4) mRNA, complete cds, alternatively spliced P
AY714243.1 Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 isoform 2 (PFKFB4) mRNA, complete cds, alternatively spliced P
AY756064.1 Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 splice isoform 5 mRNA, complete cds, alternatively spliced P
AY756063.1 Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 splice isoform 4 mRNA, complete cds, alternatively spliced P
AY756062.1 Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 splice isoform 3 mRNA, complete cds, alternatively spliced P
BC010269.1 Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, mRNA (cDNA clone MGC:5104 IMAGE:2900872), complete cds PA
AK312623.1 Homo sapiens cDNA, FLJ93007, highly similar to Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), mRNA P
D49818.1 Homo sapiens mRNA for 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, complete cds P
AK299097.1 Homo sapiens cDNA FLJ53771 complete cds, highly similar to 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 P
AK298732.1 Homo sapiens cDNA FLJ58271 complete cds, highly similar to 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 P

EST sequences (10 of 200) [Show all sequences]

AI093578.1 Clone IMAGE:1696376 uterus 3' read A
AI123746.1 Clone IMAGE:1566820 mixed 3' read A
BX117634.1 Clone IMAGp998G13121_;_IMAGE:124452 mixed
AI220522.1 Clone IMAGE:1838477 testis 3' read A
AI336996.1 Clone IMAGE:2009510 uncharacterized tissue 3' read A
AI633801.1 Clone IMAGE:2242121 uncharacterized tissue 3' read A
AI689469.1 Clone IMAGE:2277244 uterus 3' read A
AI699909.1 Clone IMAGE:2241222 uncharacterized tissue 3' read A
AI699924.1 Clone IMAGE:2241240 uncharacterized tissue 3' read A
AL038786.1 Clone DKFZp566N1546 kidney 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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