NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
Finding cDNAs

UGID:686667     UniGene Hs.471508     Homo sapiens (human)   IRS1
Insulin receptor substrate 1 (IRS1)

Human protein-coding gene IRS1. Represented by 198 ESTs from 103 cDNA libraries. Corresponds to reference sequence NM_005544.2. [UniGene 686667 - Hs.471508]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_005535.1 IRS1 gene product H. sapiens 100.0 1241
XP_001134895.1 PREDICTED: insulin receptor substrate 1 isoform 2 P. troglodytes 99.5 1240
NP_034700.2 Irs1 gene product M. musculus 93.3 1230
XP_687702.4 PREDICTED: insulin receptor substrate 1-B-like D. rerio 68.8 1091
NP_001084092.1 insulin receptor substrate 1-A X. laevis 66.2 878
Other hits (2 of 21) [Show all]SpeciesId(%)Len(aa)
XP_003908070.1 PREDICTED: insulin receptor substrate 1 P. anubis 98.8 1247
XP_001109882.1 PREDICTED: insulin receptor substrate 1-like M. mulatta 98.6 1251

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: connective tissue; pharynx; ovary; embryonic tissue; heart; larynx; intestine; prostate; pancreas; muscle; stomach; skin; brain; uncharacterized tissue; placenta; uterus; lung; mixed; testis; mammary gland; eye; liver; thyroid; kidney; amniotic fluid; trachea; thymus; bladder; bone; ear; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 2
Map position: 2q36
UniSTS entry: Chr 2 D2S2647 [Map Viewer]
UniSTS entry: Chr 2 SHGC-52849
UniSTS entry: Chr 2 RH17903
UniSTS entry: Chr 2 GDB:456125
UniSTS entry: Chr 2 WI-18042 [Map Viewer]
UniSTS entry: Chr 2 RH48158 [Map Viewer]
UniSTS entry: Chr 2 PMC86565P4
UniSTS entry: Chr 2 IRS1_V113
UniSTS entry: Chr 2 GDB:456117
UniSTS entry: Chr 2 IRS1
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (3)

BC053895.1 Homo sapiens insulin receptor substrate 1, mRNA (cDNA clone MGC:61462 IMAGE:6144252), complete cds PA
NM_005544.2 Homo sapiens insulin receptor substrate 1 (IRS1), mRNA P
S62539.1 insulin receptor substrate-1 [human, skeletal muscle, mRNA, 5828 nt] PA

EST sequences (10 of 198) [Show all sequences]

AI005248.1 Clone IMAGE:1624857 embryonic tissue 3' read
CB053406.1 Clone IMAGE:3290827 uncharacterized tissue 3' read A
CB053407.1 Clone IMAGE:3290827 uncharacterized tissue 5' read
AI150624.1 Clone IMAGE:1708382 heart 3' read
AI167323.1 Clone IMAGE:1661219 mixed 3' read P
CB111063.1 Clone L5HLK1-8-A12 liver 5' read
AA909699.1 Clone IMAGE:1523665 mixed 3' read A
AI580782.1 Clone IMAGE:2043120 uterus 3' read
AL039246.1 Clone DKFZp727K121 mammary gland 5' read P
AL048568.1 Clone DKFZp586A072 uterus P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help