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UGID:686667     UniGene Hs.471508     Homo sapiens (human)   IRS1
Insulin receptor substrate 1 (IRS1)

Human protein-coding gene IRS1. Represented by 198 ESTs from 103 cDNA libraries. Corresponds to reference sequence NM_005544.2. [UniGene 686667 - Hs.471508]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_005535.1 IRS1 gene product H. sapiens 100.0 1241
XP_001134895.1 PREDICTED: insulin receptor substrate 1 isoform 2 P. troglodytes 99.5 1240
NP_034700.2 Irs1 gene product M. musculus 93.3 1230
XP_687702.4 PREDICTED: insulin receptor substrate 1-B-like D. rerio 68.8 1091
NP_001084092.1 insulin receptor substrate 1-A X. laevis 66.2 878
Other hits (2 of 21) [Show all]SpeciesId(%)Len(aa)
XP_003908070.1 PREDICTED: insulin receptor substrate 1 P. anubis 98.8 1247
XP_001109882.1 PREDICTED: insulin receptor substrate 1-like M. mulatta 98.6 1251

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: connective tissue; pharynx; ovary; embryonic tissue; heart; larynx; intestine; prostate; pancreas; muscle; stomach; skin; brain; uncharacterized tissue; placenta; uterus; lung; mixed; testis; mammary gland; eye; liver; thyroid; kidney; amniotic fluid; trachea; thymus; bladder; bone; ear; nerve
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 2
Map position: 2q36
UniSTS entry: Chr 2 D2S2647 [Map Viewer]
UniSTS entry: Chr 2 SHGC-52849
UniSTS entry: Chr 2 RH17903
UniSTS entry: Chr 2 GDB:456125
UniSTS entry: Chr 2 WI-18042 [Map Viewer]
UniSTS entry: Chr 2 RH48158 [Map Viewer]
UniSTS entry: Chr 2 PMC86565P4
UniSTS entry: Chr 2 IRS1_V113
UniSTS entry: Chr 2 GDB:456117
UniSTS entry: Chr 2 IRS1
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (3)

BC053895.1 Homo sapiens insulin receptor substrate 1, mRNA (cDNA clone MGC:61462 IMAGE:6144252), complete cds PA
NM_005544.2 Homo sapiens insulin receptor substrate 1 (IRS1), mRNA P
S62539.1 insulin receptor substrate-1 [human, skeletal muscle, mRNA, 5828 nt] PA

EST sequences (10 of 198) [Show all sequences]

AI005248.1 Clone IMAGE:1624857 embryonic tissue 3' read
CB053406.1 Clone IMAGE:3290827 uncharacterized tissue 3' read A
CB053407.1 Clone IMAGE:3290827 uncharacterized tissue 5' read
AI150624.1 Clone IMAGE:1708382 heart 3' read
AI167323.1 Clone IMAGE:1661219 mixed 3' read P
CB111063.1 Clone L5HLK1-8-A12 liver 5' read
AA909699.1 Clone IMAGE:1523665 mixed 3' read A
AI580782.1 Clone IMAGE:2043120 uterus 3' read
AL039246.1 Clone DKFZp727K121 mammary gland 5' read P
AL048568.1 Clone DKFZp586A072 uterus P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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