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UGID:681823     UniGene Hs.466664     Homo sapiens (human)   RYR1
Ryanodine receptor 1 (skeletal) (RYR1)

Human protein-coding gene RYR1. Represented by 122 ESTs from 55 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 681823 - Hs.466664]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000531.2 RYR1 gene product H. sapiens 100.0 5037
XP_003316361.1 PREDICTED: ryanodine receptor 1 isoform 1 P. troglodytes 99.8 5036
NP_033135.2 Ryr1 gene product M. musculus 96.7 5031
XP_001923294.3 PREDICTED: hypothetical protein LOC798565 D. rerio 81.4 5058
NP_001256074.1 Protein UNC-68, isoform a C. elegans 54.4 3063
NP_476992.1 ryanodine receptor 44F, isoform B D. melanogaster 52.8 5107
Other hits (2 of 33) [Show all]SpeciesId(%)Len(aa)
XP_003915531.1 PREDICTED: ryanodine receptor 1-like, partial P. anubis 99.4 2986
XP_003638883.1 PREDICTED: ryanodine receptor 1 isoform 2 C. lupus familiaris 97.7 5037

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; muscle; uncharacterized tissue; larynx; pharynx; ovary; mouth; testis; cervix; pancreas; thyroid; embryonic tissue; epididymis; placenta; lung; intestine; mixed; eye; uterus; ganglia; bone; kidney
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19q13.1
UniSTS entry: Chr 19 D19S626E
UniSTS entry: Chr 19 PMC22438P1
UniSTS entry: Ryr2
UniSTS entry: Chr 19 RYR1
UniSTS entry: D2S1589E
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (6)

AB209425.1 Homo sapiens mRNA for ryanodine receptor 1 (skeletal) variant protein P
NM_000540.2 Homo sapiens ryanodine receptor 1 (skeletal) (RYR1), transcript variant 1, mRNA P
J05200.1 Human ryanodine receptor mRNA, complete cds P
NM_001042723.1 Homo sapiens ryanodine receptor 1 (skeletal) (RYR1), transcript variant 2, mRNA P
AK293785.1 Homo sapiens cDNA FLJ51803 complete cds, highly similar to Ryanodine receptor 1 P
AF075460.1 Homo sapiens type 1-like ryanodine receptor mRNA, partial cds P

EST sequences (10 of 122) [Show all sequences]

CB129444.1 Clone C1SNU17-5-G05 cervix 5' read P
AI364203.1 Clone IMAGE:1993107 uterus 3' read A
AI651620.1 Clone IMAGE:2304967 uncharacterized tissue 3' read P
T09039.1 Clone HIBBO26 brain 5' read P
AI660486.1 Clone IMAGE:2346202 intestine 3' read A
F24310.1 Clone s4000007D04 muscle
F31264.1 Clone s4000112A06 muscle P
F32576.1 Clone s3000041G04 muscle P
F32593.1 Clone s3000042F06 muscle P
F33036.1 Clone s3000051E03 muscle P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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