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UGID:680246     UniGene Hs.465087     Homo sapiens (human)   SMAD7
SMAD family member 7 (SMAD7)

Human protein-coding gene SMAD7. Represented by 97 ESTs from 69 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 680246 - Hs.465087]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003914414.1 PREDICTED: mothers against decapentaplegic homolog 7 P. anubis 100.0 425
XP_512124.2 PREDICTED: uncharacterized protein LOC455411 P. troglodytes 100.0 425
NP_005895.1 SMAD7 gene product H. sapiens 100.0 425
NP_001036125.1 Smad7 gene product M. musculus 99.1 425
NP_001081017.1 SMAD family member 7 X. laevis 89.0 381
NP_778257.2 smad7 gene product D. rerio 83.9 371
Other hits (2 of 23) [Show all]SpeciesId(%)Len(aa)
NP_001231104.1 mothers against decapentaplegic homolog 7 S. scrofa 99.3 424
XP_001499111.3 PREDICTED: LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 7 E. caballus 99.2 242

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: pancreas; intestine; placenta; nerve; cervix; embryonic tissue; brain; blood; bone; lung; eye; kidney; heart; mammary gland; vascular; uterus; uncharacterized tissue; mixed; thyroid; prostate; muscle; pituitary gland; connective tissue; ganglia; lymph node
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 18
Map position: 18q21.1
UniSTS entry: Chr 18 Smad7
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

NM_005904.3 Homo sapiens SMAD family member 7 (SMAD7), transcript variant 1, mRNA PA
AK131394.1 Homo sapiens cDNA FLJ16482 fis, clone BRTHA2017972, highly similar to Mothers against decapentaplegic homolog 7 (SMAD 7) P
BC074819.2 Homo sapiens SMAD family member 7, mRNA (cDNA clone MGC:104084 IMAGE:30915535), complete cds P
BC074818.2 Homo sapiens SMAD family member 7, mRNA (cDNA clone MGC:103929 IMAGE:30915321), complete cds P
AK301535.1 Homo sapiens cDNA FLJ57868 complete cds, highly similar to Mothers against decapentaplegic homolog 7 (SMAD 7) P
NM_001190823.1 Homo sapiens SMAD family member 7 (SMAD7), transcript variant 4, mRNA P
NM_001190822.1 Homo sapiens SMAD family member 7 (SMAD7), transcript variant 3, mRNA P
NM_001190821.1 Homo sapiens SMAD family member 7 (SMAD7), transcript variant 2, mRNA P
AF010193.1 Homo sapiens MAD-related gene SMAD7 (SMAD7) mRNA, complete cds PA
AF015261.1 Homo sapiens Smad7 protein mRNA, complete cds P

EST sequences (10 of 97) [Show all sequences]

BX111807.1 Clone IMAGp998E01228_;_IMAGE:148968 placenta A
AI215892.1 Clone IMAGE:1883857 lung 3' read
AI418939.1 Clone IMAGE:2102935 brain 3' read
AI635141.1 Clone IMAGE:2287416 uterus 3' read
AI752740.1 Clone NHTBC_cn18e02 bone
AI752741.1 Clone NHTBC_cn18e02 bone P
AI807690.1 Clone IMAGE:2358967 mixed 3' read
AI862651.1 Clone IMAGE:2404046 kidney 3' read
CD107222.1 Clone IMAGE:30366545 pituitary gland 5' read P
AI880894.1 Clone IMAGE:2355585 vascular 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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