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UGID:678218     UniGene Hs.463059     Homo sapiens (human)   STAT3
Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3)

Human protein-coding gene STAT3. Represented by 948 ESTs from 367 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 678218 - Hs.463059]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001165417.2 PREDICTED: signal transducer and activator of transcription 3 isoform 2 P. troglodytes 100.0 862
NP_998824.1 Stat3 gene product M. musculus 100.0 769
NP_036879.1 Stat3 gene product R. norvegicus 100.0 769
NP_644805.1 STAT3 gene product H. sapiens 100.0 769
NP_001038045.1 STAT3 gene product S. scrofa 100.0 769
NP_001012689.2 STAT3 gene product B. taurus 100.0 769
XP_002719441.1 PREDICTED: signal transducer and activator of transcription 3 isoform 1 O. cuniculus 100.0 769
XP_003362604.1 PREDICTED: signal transducer and activator of transcription 3 isoform 2 E. caballus 100.0 768
XP_004012974.1 PREDICTED: signal transducer and activator of transcription 3 O. aries 100.0 721
XP_003913118.1 PREDICTED: signal transducer and activator of transcription 3 isoform 3 P. anubis 99.9 862
XP_001363772.1 PREDICTED: signal transducer and activator of transcription 3 isoform 1 M. domestica 99.9 769
XP_548090.2 PREDICTED: signal transducer and activator of transcription 3 isoform 1 C. lupus familiaris 99.9 768
XP_002800523.1 PREDICTED: signal transducer and activator of transcription 3 isoform 2 M. mulatta 99.8 863
NP_001090202.1 signal transducer and activator of transcription 3.1 X. laevis 98.8 768
NP_571554.1 stat3 gene product D. rerio 94.3 788
Other hits (2 of 11) [Show all]SpeciesId(%)Len(aa)
XP_003213184.1 PREDICTED: signal transducer and activator of transcription 3-like M. gallopavo 99.3 770
XP_003222526.1 PREDICTED: signal transducer and activator of transcription 3-like A. carolinensis 99.2 770

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; mouth; lung; liver; uterus; embryonic tissue; uncharacterized tissue; thymus; skin; placenta; trachea; pancreas; spleen; blood; intestine; mixed; mammary gland; bone marrow; ovary; connective tissue; muscle; kidney; eye; lymph node; prostate; amniotic fluid; tonsil; thyroid; vascular; larynx; pharynx; esophagus; stomach; pituitary gland; bladder; nerve; salivary gland; ganglia; cervix; heart; ascites; ear; adrenal gland; adipose tissue; bone
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 17
Map position: 17q21.31
UniSTS entry: Chr 17 RH102656
UniSTS entry: Chr 17 STS-W49595 [Map Viewer]
UniSTS entry: Chr 17 A008U14 [Map Viewer]
UniSTS entry: Chr 17 D17S1460E
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (16)

AJ012463.1 Homo sapiens mRNA for transcription factor P
NM_003150.3 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 2, mRNA P
BC067119.1 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone IMAGE:5539333) A
NM_213662.1 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3, mRNA P
AK024535.1 Homo sapiens cDNA: FLJ20882 fis, clone ADKA03206 A
BC107775.1 Homo sapiens cDNA clone IMAGE:6450121 A
BC000627.2 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone MGC:1607 IMAGE:3347434), complete cds PA
BC008044.2 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone IMAGE:3614611) A
BC014482.1 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone MGC:23173 IMAGE:4909141), complete cds PA
AK291933.1 Homo sapiens cDNA FLJ78360 complete cds, highly similar to Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mRNA P
NM_139276.2 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mRNA P
AK301200.1 Homo sapiens cDNA FLJ53413 complete cds, highly similar to Signal transducer and activator of transcription 3 P
AK297994.1 Homo sapiens cDNA FLJ59362 complete cds, highly similar to Signal transducer and activator of transcription 3 P
AB451232.1 Homo sapiens STAT3 mRNA for signal transducer and activator of transcription 3 isoform 2, complete cds, clone: FLJ08023AAAN P
AF029311.1 Homo sapiens signal transducer and activator of transcription 3 (STAT3) mRNA, partial cds P
AK316139.1 Homo sapiens cDNA, FLJ79038 complete cds, highly similar to Signal transducer and activator of transcription 3 P

EST sequences (10 of 948) [Show all sequences]

AA863403.1 Clone IMAGE:1469311 uncharacterized tissue 3' read
AA969230.1 Clone IMAGE:1560750 mixed 3' read A
AA993656.1 Clone IMAGE:1623614 embryonic tissue 3' read A
AA993944.1 Clone IMAGE:1628855 mixed 3' read A
AI017902.1 Clone IMAGE:1628313 mixed 3' read A
AI023361.1 Clone IMAGE:1651532 skin 3' read A
AI091808.1 Clone IMAGE:1690940 mixed 3' read
AI139252.1 Clone IMAGE:1710102 heart 3' read A
CB068474.1 Clone IMAGE:6365233 pancreas 3' read P
AI086516.1 Clone IMAGE:1679734 skin 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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