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UGID:231587     UniGene Hs.436550     Homo sapiens (human)   SCN8A
Sodium channel, voltage gated, type VIII, alpha subunit (SCN8A)

Human protein-coding gene SCN8A. Represented by 78 ESTs from 44 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 231587 - Hs.436550]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_055006.1 SCN8A gene product H. sapiens 100.0 1979
XP_001090295.1 PREDICTED: sodium channel protein type 8 subunit alpha isoform 1 M. mulatta 100.0 1979
NP_001180031.1 sodium channel protein type 8 subunit alpha B. taurus 99.7 1979
NP_001070967.1 Scn8a gene product M. musculus 98.9 1977
NP_571703.1 scn8aa gene product D. rerio 83.3 1948
NP_001188629.1 paralytic, isoform AH D. melanogaster 49.8 1965
Other hits (2 of 37) [Show all]SpeciesId(%)Len(aa)
XP_850134.1 PREDICTED: sodium channel protein type 8 subunit alpha isoform 2 C. lupus familiaris 99.5 1979
XP_003481629.1 PREDICTED: LOW QUALITY PROTEIN: sodium channel protein type 8 subunit alpha-like S. scrofa 99.4 1979

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; lung; mouth; embryonic tissue; mammary gland; testis; skin; kidney; eye; uncharacterized tissue; liver; mixed; pituitary gland; heart
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12q13
UniSTS entry: Chr 12 RH11256 [Map Viewer]
UniSTS entry: Chr 12 G43469
UniSTS entry: Chr 12 WI-15800 [Map Viewer]
UniSTS entry: Chr 12 G64248
UniSTS entry: Scn4a
UniSTS entry: Chr 12 SCN8A_3459
UniSTS entry: Chr 12 A006S01 [Map Viewer]
UniSTS entry: Chr 12 RH78513
UniSTS entry: Chr 12 RH92945
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (17)

AB027567.1 Homo sapiens SCN8A mRNA for sodium channel, complete cds P
AF225988.1 Homo sapiens voltage-gated sodium channel alpha subunit (SCN8A) mRNA, complete cds PA
NM_014191.3 Homo sapiens sodium channel, voltage gated, type VIII, alpha subunit (SCN8A), transcript variant 1, mRNA PA
AY682083.1 Homo sapiens voltage-gated sodium channel Nav1.6 (SCN8A) mRNA, partial cds, alternatively spliced P
AY682082.1 Homo sapiens voltage-gated sodium channel Nav1.6 (SCN8A) mRNA, partial cds, alternatively spliced P
AY682081.1 Homo sapiens voltage-gated sodium channel Nav1.6 (SCN8A) mRNA, partial cds, alternatively spliced P
AK309213.1 Homo sapiens cDNA, FLJ99254 P
AK091315.1 Homo sapiens cDNA FLJ33996 fis, clone DFNES2008881 A
AJ310898.1 Homo sapiens partial mRNA for voltage-gated sodium channel Nav1.6 (SCN8A gene), cell line MCF-7
AJ310885.1 Homo sapiens partial mRNA for voltage-gated sodium channel Nav1.6 (SCN8A gene), D3 neonatal splice variant, cell line MCF-7 P
AJ310884.1 Homo sapiens mRNA for Nav1.6 voltage-gated sodium channel (SCN8A gene) Nav1.6, D3 neonatal splice variant, cell lines MDA-MB-231 P
AJ277395.1 Homo sapiens partial mRNA for voltage-gated sodium channel (SCN8A gene) P
AJ276142.1 Homo sapiens partial mRNA for hNa6/Scn8a voltage-gated sodium channel (SCN8A gene), cell line LNCaP P
AJ276141.1 Homo sapiens partial mRNA for hNa6/Scn8a voltage-gated sodium channel (SCN8A gene), cell line PC-3 P
Z50169.1 H. sapiens partial mRNA; single read (clone A33292) P
FJ611941.1 Homo sapiens monocyte-macrophage NaV1.6 splice variant (SCN8A) mRNA, complete cds, alternatively spliced P
NM_001177984.2 Homo sapiens sodium channel, voltage gated, type VIII, alpha subunit (SCN8A), transcript variant 2, mRNA PA

EST sequences (10 of 78) [Show all sequences]

R14117.1 Clone IMAGE:27533 brain 5' read
R14916.1 Clone IMAGE:30318 brain 5' read
R19755.1 Clone IMAGE:34740 brain 5' read
AI056616.1 Clone IMAGE:1674980 mixed 3' read
AI093684.1 Clone IMAGE:1688367 mixed 3' read A
AI131238.1 Clone IMAGE:1709749 heart 3' read
BX109788.1 Clone IMAGp998D14165_;_IMAGE:37538 brain A
BX112779.1 Clone IMAGp998H15145_;_IMAGE:28927 brain A
CB152209.1 Clone B1T694954-24-G03 brain 5' read
AI291173.1 Clone IMAGE:1881462 lung 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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