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UGID:229062     UniGene Hs.433951     Homo sapiens (human)   GPX4
Glutathione peroxidase 4 (GPX4)

Human protein-coding gene GPX4. Represented by 1129 ESTs from 303 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 229062 - Hs.433951]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001034937.1 GPX4 gene product H. sapiens 99.6 233
NP_001112361.1 GPX4 gene product M. mulatta 99.5 196
XP_003914617.1 PREDICTED: LOW QUALITY PROTEIN: phospholipid hydroperoxide glutathione peroxidase, mitochondrial P. anubis 99.5 196
NP_001139295.1 glutathione peroxidase 4 P. troglodytes 99.2 233
NP_032188.3 Gpx4 gene product M. musculus 95.4 196
NP_001025241.2 gpx4b gene product D. rerio 77.9 189
NP_001165215.1 glutathione peroxidase 4 a X. laevis 77.0 195
NP_191867.1 glutathione peroxidase A. thaliana 48.0 172
Other hits (2 of 33) [Show all]SpeciesId(%)Len(aa)
NP_999572.1 GPX4 gene product S. scrofa 95.4 196
NP_777195.1 GPX4 gene product B. taurus 93.9 196

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; lung; eye; pancreas; prostate; liver; uterus; intestine; uncharacterized tissue; mixed; placenta; kidney; heart; skin; muscle; embryonic tissue; mammary gland; ovary; bone; bladder; nerve; spleen; mouth; pineal gland; larynx; adrenal gland; stomach; thyroid; lymph node; blood; ascites; lymph; vascular; connective tissue; thymus; cervix; parathyroid; pharynx; salivary gland; adipose tissue; pituitary gland; bone marrow; tonsil; epididymis
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19p13.3
UniSTS entry: Chr 19 STS-X71973
UniSTS entry: Chr 19 RH16004
UniSTS entry: Chr 19 MARC_7967-7968:996688192:1
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (13)

BC046163.1 Homo sapiens glutathione peroxidase 4 (phospholipid hydroperoxidase), mRNA (cDNA clone MGC:57716 IMAGE:5742889), complete cds PA
BC058329.1 Homo sapiens glutathione peroxidase 4 (phospholipid hydroperoxidase), mRNA (cDNA clone IMAGE:6527068) PA
NM_002085.3 Homo sapiens glutathione peroxidase 4 (GPX4), transcript variant 1, mRNA PA
NM_001039848.1 Homo sapiens glutathione peroxidase 4 (GPX4), transcript variant 3, mRNA PA
NM_001039847.1 Homo sapiens glutathione peroxidase 4 (GPX4), transcript variant 2, mRNA PA
AK225859.1 Homo sapiens mRNA for Phospholipid hydroperoxide glutathione peroxidase, mitochondrial precursor variant, clone: FCC125B05 PA
X71973.1 H.sapiens GPx-4 mRNA for phospholipid hydroperoxide glutathione peroxidase PA
BC032695.1 Homo sapiens glutathione peroxidase 4 (phospholipid hydroperoxidase), mRNA (cDNA clone MGC:45347 IMAGE:5227887), complete cds PA
BC022071.1 Homo sapiens glutathione peroxidase 4 (phospholipid hydroperoxidase), mRNA (cDNA clone MGC:33153 IMAGE:4821595), complete cds PA
BC021567.1 Homo sapiens glutathione peroxidase 4 (phospholipid hydroperoxidase), mRNA (cDNA clone MGC:31923 IMAGE:4581069), complete cds PA
BC011836.2 Homo sapiens glutathione peroxidase 4 (phospholipid hydroperoxidase), mRNA (cDNA clone MGC:20094 IMAGE:3945177), complete cds PA
BC010157.2 Homo sapiens glutathione peroxidase 4 (phospholipid hydroperoxidase), mRNA (cDNA clone IMAGE:3617438), complete cds PA
BC039849.1 Homo sapiens glutathione peroxidase 4 (phospholipid hydroperoxidase), mRNA (cDNA clone MGC:48873 IMAGE:5744771), complete cds PA

EST sequences (10 of 1129) [Show all sequences]

AA866106.1 Clone IMAGE:1470313 uncharacterized tissue 3' read A
AA888171.1 Clone IMAGE:1492142 kidney 3' read PA
AA975868.1 Clone IMAGE:1555645 kidney 3' read A
AA977808.1 Clone IMAGE:1591554 kidney 3' read A
AA991230.1 Clone IMAGE:1607850 mammary gland 3' read A
AA991970.1 Clone IMAGE:1613566 uncharacterized tissue 3' read A
AA992915.1 Clone IMAGE:1624234 embryonic tissue 3' read A
AA994017.1 Clone IMAGE:1628941 mixed 3' read A
AA887242.1 Clone IMAGE:1500339 lung 3' read PA
AA887529.1 Clone IMAGE:1500540 lung 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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