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UGID:228011     UniGene Hs.431850     Homo sapiens (human)   MAPK1
Mitogen-activated protein kinase 1 (MAPK1)

Human protein-coding gene MAPK1. Represented by 1104 ESTs from 363 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 228011 - Hs.431850]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003905323.1 PREDICTED: mitogen-activated protein kinase 1 P. anubis 100.0 359
XP_003317171.1 PREDICTED: mitogen-activated protein kinase 1 isoform 1 P. troglodytes 100.0 359
NP_620407.1 MAPK1 gene product H. sapiens 100.0 359
NP_001104270.1 mitogen-activated protein kinase 1 C. lupus familiaris 100.0 359
NP_786987.1 MAPK1 gene product B. taurus 100.0 359
NP_001185851.1 MAPK1 gene product S. scrofa 100.0 358
NP_036079.1 Mapk1 gene product M. musculus 100.0 357
NP_446294.1 Mapk1 gene product R. norvegicus 100.0 357
XP_001089600.2 PREDICTED: mitogen-activated protein kinase 1 M. mulatta 100.0 347
XP_002719777.1 PREDICTED: mitogen-activated protein kinase 1-like O. cuniculus 100.0 284
NP_989481.1 MAPK1 gene product G. gallus 99.7 366
XP_001378209.2 PREDICTED: mitogen-activated protein kinase 1-like M. domestica 99.7 358
XP_003210902.1 PREDICTED: mitogen-activated protein kinase 1-like M. gallopavo 99.7 323
NP_001083548.1 mitogen-activated protein kinase 1 X. laevis 99.2 360
NP_878308.2 mapk1 gene product D. rerio 98.1 367
NP_001104349.1 rolled, isoform E D. melanogaster 90.3 370
NP_001022583.1 Protein MPK-1, isoform a C. elegans 88.7 346
XP_959713.2 mitogen-activated kinase-2 N. crassa 67.5 353
XP_001700291.1 mitogen-activated protein kinase 8 C. reinhardtii 61.5 340
NP_011554.3 Kss1p S. cerevisiae 59.4 362
NP_181907.1 mitogen-activated protein kinase 6 A. thaliana 58.9 392
Other hits (2 of 56) [Show all]SpeciesId(%)Len(aa)
NP_001017127.1 mapk1 gene product X. tropicalis 99.5 360
XP_004017726.1 PREDICTED: mitogen-activated protein kinase 1 O. aries 99.4 334

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; uncharacterized tissue; mouth; mixed; uterus; skin; embryonic tissue; eye; lymph node; lung; mammary gland; intestine; liver; pancreas; kidney; placenta; prostate; muscle; pharynx; trachea; blood; salivary gland; vascular; bone; thymus; connective tissue; ovary; thyroid; stomach; heart; adrenal gland; spleen; cervix; ascites; ear; bone marrow; larynx; bladder; nerve; umbilical cord; parathyroid; ganglia
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 22
Map position: 22q11.21
UniSTS entry: Chr 22 G30303
UniSTS entry: Chr 22 D22S1022E
UniSTS entry: Chr 22 D22S1011E
UniSTS entry: Mapk1
UniSTS entry: Chr 22 SHGC-172572
UniSTS entry: Chr 22 MAPK1_V207
UniSTS entry: RH76479
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (14)

NM_002745.4 Homo sapiens mitogen-activated protein kinase 1 (MAPK1), transcript variant 1, mRNA P
AL157438.1 Homo sapiens mRNA; cDNA DKFZp434A115 (from clone DKFZp434A115) A
BC099905.1 Homo sapiens mitogen-activated protein kinase 1, mRNA (cDNA clone MGC:104558 IMAGE:5264558), complete cds PA
Z11695.1 H.sapiens 40 kDa protein kinase related to rat ERK2 PA
Z11694.1 H.sapiens 41kDa protein kinase related to rat ERK2 P
EF565108.1 Homo sapiens chromosome 22 isolate HA_003333 mRNA sequence P
AK057143.1 Homo sapiens cDNA FLJ32581 fis, clone SPLEN2000304
AK055080.1 Homo sapiens cDNA FLJ30518 fis, clone BRAWH2000839
BC017832.1 Homo sapiens mitogen-activated protein kinase 1, mRNA (cDNA clone MGC:22485 IMAGE:4685557), complete cds PA
DQ399292.1 Homo sapiens extracellular signal-regulated kinase-2 splice variant mRNA, complete cds, alternatively spliced P
AK307615.1 Homo sapiens cDNA, FLJ97563 P
NM_138957.2 Homo sapiens mitogen-activated protein kinase 1 (MAPK1), transcript variant 2, mRNA P
AK090869.1 Homo sapiens cDNA FLJ33550 fis, clone BRAMY2009034, highly similar to MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.-) P
AK295188.1 Homo sapiens cDNA FLJ58314 complete cds, highly similar to Mitogen-activated protein kinase 1 (EC 2.7.11.24) P

EST sequences (10 of 1104) [Show all sequences]

AA954489.1 Clone IMAGE:1563068 mixed 3' read A
AA972486.1 Clone IMAGE:1579528 mixed 3' read A
AA975910.1 Clone IMAGE:1567980 lung 3' read A
AA992534.1 Clone IMAGE:1621973 embryonic tissue 3' read A
R17311.1 Clone IMAGE:31862 brain 5' read
AI004470.1 Clone IMAGE:1620797 testis 3' read A
R18100.1 Clone IMAGE:32395 brain 5' read
AI033078.1 Clone IMAGE:1654413 mixed 3' read A
AI034296.1 Clone IMAGE:1663550 skin 3' read A
R19611.1 Clone IMAGE:33777 brain 5' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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