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UGID:222609     UniGene Hs.414795     Homo sapiens (human)   SERPINE1
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1)

Human protein-coding gene SERPINE1. Represented by 988 ESTs from 203 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 222609 - Hs.414795]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_527841.3 PREDICTED: plasminogen activator inhibitor 1 isoform 2 P. troglodytes 100.0 401
NP_000593.1 SERPINE1 gene product H. sapiens 100.0 401
NP_032897.2 Serpine1 gene product M. musculus 84.3 401
NP_001090520.1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 precursor X. laevis 61.3 402
NP_001108031.1 serpine1 gene product D. rerio 50.7 358
Other hits (2 of 20) [Show all]SpeciesId(%)Len(aa)
XP_001107647.1 PREDICTED: plasminogen activator inhibitor 1-like isoform 2 M. mulatta 98.3 401
XP_003895863.1 PREDICTED: plasminogen activator inhibitor 1 P. anubis 98.3 401

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: placenta; embryonic tissue; skin; vascular; liver; lung; pancreas; connective tissue; umbilical cord; bone; uncharacterized tissue; mixed; brain; heart; testis; bone marrow; bladder; kidney; epididymis; larynx; uterus; eye; amniotic fluid; stomach; thyroid; nerve; esophagus; intestine; mammary gland; cervix; ovary; muscle; pharynx; thymus; blood; lymph node; adipose tissue
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 7
Map position: 7q22.1
UniSTS entry: Chr 7 RH48262
UniSTS entry: Chr 7 STS-D29544 [Map Viewer]
UniSTS entry: Chr 7 G10517
UniSTS entry: Chr 7 GDB:3755009
UniSTS entry: Chr 7 GDB:512828
UniSTS entry: Chr 6 RH41034
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (13)

M16006.1 Human plasminogen activator inhibitor-1 (PAI-1) mRNA, complete cds P
M14083.1 Human beta-migrating plasminogen activator inhibitor I mRNA, 3' end P
NM_000602.4 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), transcript variant 1, mRNA PA
BC010860.1 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, mRNA (cDNA clone MGC:9226 IMAGE:3893914), complete cds PA
X04429.1 Human mRNA for endothelial plasminogen activator inhibitor (PAI) P
X12701.1 H.sapiens mRNA for endothelial plasminogen activator inhibitor PAI P
X04744.1 Human mRNA for plasminogen activator inhibitor (PAI-1) P
AK316225.1 Homo sapiens cDNA, FLJ79124 complete cds, highly similar to Plasminogen activator inhibitor 1 precursor P
AK298048.1 Homo sapiens cDNA FLJ51012 complete cds, highly similar to Plasminogen activator inhibitor 1 precursor P
AK297728.1 Homo sapiens cDNA FLJ53064 complete cds, highly similar to Plasminogen activator inhibitor 1 precursor P
AK293248.1 Homo sapiens cDNA FLJ61097 complete cds, highly similar to Plasminogen activator inhibitor 1 precursor P
NM_001165413.2 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), transcript variant 2, mRNA PA
X04731.1 Human mRNA for plasminogen activator inhibitor type 1 C-terminus

EST sequences (10 of 988) [Show all sequences]

AA962576.1 Clone IMAGE:1553629 kidney 3' read
AA989524.1 Clone IMAGE:1606293 kidney 3' read
AI040019.1 Clone IMAGE:1664304 skin 3' read A
AI041790.1 Clone IMAGE:1665407 skin 3' read A
AI041958.1 Clone IMAGE:1665456 skin 3' read
AI049954.1 Clone IMAGE:1700615 kidney 3' read
AI050745.1 Clone IMAGE:1663986 skin 3' read
AI056745.1 Clone IMAGE:1673890 mixed 3' read
AI077730.1 Clone IMAGE:1663738 skin 3' read
AI077741.1 Clone IMAGE:1663739 skin 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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