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UGID:221448     UniGene Hs.409934     Homo sapiens (human)   HLA-DQB1
Major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1)

Human protein-coding gene HLA-DQB1. Represented by 485 ESTs from 206 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 221448 - Hs.409934]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001230890.1 HLA-DQB1 gene product H. sapiens 100.0 268
NP_996988.2 H2-Ab1 gene product M. musculus 82.9 263
NP_001177324.1 uncharacterized protein LOC100462907 precursor X. laevis 56.8 252
Other hits (2 of 16) [Show all]SpeciesId(%)Len(aa)
XP_003339166.1 PREDICTED: HLA class II histocompatibility antigen, DQ beta 1 chain-like P. troglodytes 98.1 260
XP_003897463.1 PREDICTED: HLA class II histocompatibility antigen, DQ beta 1 chain-like P. anubis 95.4 260

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lung; lymph node; mixed; embryonic tissue; prostate; connective tissue; brain; liver; spleen; blood; tonsil; mouth; uterus; intestine; uncharacterized tissue; pituitary gland; kidney; bone marrow; thyroid; placenta; muscle; trachea; lymph; eye; bladder; ovary; testis; mammary gland; pharynx; stomach; cervix; adrenal gland; pancreas; thymus; skin; adipose tissue; vascular; nerve; bone; esophagus
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 6
Map position: 6p21.3
UniSTS entry: Chr 6 D6S2202
UniSTS entry: Chr 6 RH46706 [Map Viewer]
UniSTS entry: Chr 6 D6S1841 [Map Viewer]
UniSTS entry: Chr 6 STS-K02405 [Map Viewer]
UniSTS entry: RH80803
UniSTS entry: Chr 6 RH36565 [Map Viewer]
UniSTS entry: HLA-DQB1_3386
UniSTS entry: Chr 6 D6S2447
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (88)

M24364.1 Human MHC class II lymphocyte antigen DQB mRNA, complete cds, haplotype DR7, DQw9 P
M17955.1 Human MHC class II HLA-DQ-beta mRNA, complete cds P
M26042.1 Human MHC class II DQ beta mRNA, complete cds P
NM_002123.4 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 1, mRNA PA
AY656683.1 Homo sapiens MHC class II antigen (HLA-DQB1) mRNA, HLA-DQB1*0401 allele, complete cds P
AY656682.1 Homo sapiens MHC class II antigen (HLA-DQB1) mRNA, HLA-DQB1*030101 allele, complete cds P
AY656681.1 Homo sapiens MHC class II antigen (HLA-DQB1) mRNA, HLA-DQB1*050201 allele, complete cds P
M33907.1 Human MHC class II HLA-DQB1 mRNA, complete cds P
AF195245.1 Homo sapiens MHC class II antigen (HLA-DQB1) mRNA, HLA-DQB1 variant allele, partial cds P
AB209638.1 Homo sapiens mRNA for MHC class II antigen variant protein P
DQ136036.1 Homo sapiens cell-line HCT 116 MHC class II antigen precursor (HLA-DQB1) mRNA, HLA-DQB1*03 variant allele, partial cds P
M60028.1 Human MHC class II HLA-DQ-beta (DQB1,DQw9), complete cds P
M17563.1 Human MHC class II DQ-beta associated with DR2, DQw1 protein, complete cds P
M17564.1 Human MHC class II DQ-beta associated with DR1, DQw1 protein, complete cds P
M20432.1 Human MHC class II HLA-DQ-beta (DR2-DQw1/DR4 DQw3) mRNA, complete cds, clone ROF2D P
M16996.1 Human MHC class II HLA-DQ-beta (DQw3), complete cds P
M81140.1 Human MHC class II HLA-DQ-beta mRNA (B8 DR3 DQw2), complete cds P
M81141.1 Human MHC class II HLA-DQ-beta mRNA (DR7 DQw2), complete cds P
J00198.1 human hla-dr antigen-like beta chain mrna P
M16276.1 Human MHC class II HLA-DR2-Dw12 mRNA DQw1-beta, complete cds P
L34095.1 Human (clone 3) MHC class II HLA-DQB1*0202 mRNA, 3' end P
L34097.1 Human (clone 36) MHC class II HLA-DQB1*0302 mRNA, 3' end P
L34098.1 Human (clones 2, 3) MHC class II HLA-DQB1*03032 mRNA, 3' end P
L34100.1 Human (clones 1, 2) MHC class II HLA-DQB1*0402 mRNA, 3' end P
L34101.1 Human (clone 3-19) MHC class II HLA-DQB1*0501 mRNA, 3' end P
L34102.1 Human (clone 1-33-4) MHC class II HLA-DQB1*0502 mRNA, 3' end P
L34104.1 Human (clone 26) MHC class II HLA-DQB1*06011 mRNA, 3' end P
L34105.1 Human (clone 1) MHC class II HLA-DQB1*0602 mRNA, 3' end P
L34106.1 Human (clone 32) MHC class II HLA-DQB1*0603 mRNA, 3' end P
L34107.1 Human (clone 1-53) MHC class II HLA-DQB1*0604 mRNA, 3' end P
BC128595.1 Homo sapiens major histocompatibility complex, class II, DQ beta 1, mRNA (cDNA clone IMAGE:40127514), partial cds P
L34096.1 Human (clones 3, 4) MHC class II HLA-DQB1*0301 mRNA, 3' end P
L34099.1 Human (clone 22) MHC class II HLA-DQB1*0401 mRNA, 3' end P
L34103.1 Human (clone 2-4, 2-5) MHC class II HLA-DQB1*05031 mRNA, 3' end P
X03068.1 Human mRNA for HLA-D class II antigen DQw1.1 beta chain P
AF291674.1 Homo sapiens MHC class II antigen (HLA-DQB1) mRNA, HLA-DQB1*05 allele, complete cds P
BC012106.1 Homo sapiens major histocompatibility complex, class II, DQ beta 1, mRNA (cDNA clone MGC:20093 IMAGE:4574913), complete cds PA
BC128594.1 Homo sapiens cDNA clone IMAGE:40127512 P
BC150556.1 Homo sapiens cDNA clone IMAGE:40127516 P
BC150555.1 Homo sapiens cDNA clone IMAGE:40127515 P
AK097297.1 Homo sapiens cDNA FLJ39978 fis, clone SPLEN2029380
AK304543.1 Homo sapiens cDNA FLJ59004 complete cds, highly similar to HLA class II histocompatibility antigen, DQ(1)beta chain precursor P
AK296613.1 Homo sapiens cDNA FLJ52646 complete cds, highly similar to HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor P
AK296060.1 Homo sapiens cDNA FLJ53582 complete cds, highly similar to HLA class II histocompatibility antigen, DQ(1)beta chain precursor P
AK295695.1 Homo sapiens cDNA FLJ57489 complete cds, highly similar to HLA class II histocompatibility antigen,DQB1*0602 beta chain precursor P
AK295476.1 Homo sapiens cDNA FLJ59895 complete cds, highly similar to HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor P
AK295255.1 Homo sapiens cDNA FLJ56572 complete cds, highly similar to HLA class II histocompatibility antigen, DQ(1)beta chain precursor P
X00369.1 Human mRNA for HLA-DC classII histocompatibility antigen beta-chain P
AF113250.1 Homo sapiens MHC class II antigen HLA-DQB1 gene (HLA-DQB1*0604 variant allele) mRNA, partial cds P
U83585.1 Homo sapiens MHC class II antigen HLA-DQ mRNA (HLA-DQB1*06 allele), partial cds P
AF000447.1 Homo sapiens MHC class II HLA-DQB1 mRNA (HLA-DQB1-06Var allele), partial cds P
U63321.1 Human MHC class II antigen (HLA-DQB1) mRNA, allele HLA-DQB1*0604v, partial cds P
V00529.1 Human mRNA fragment coding for histocompatibility antigen HLA-DR (beta subunit)
X76554.1 H.sapiens mRNA for HLA-DQB1*0305 P
X76553.1 H.sapiens mRNA for HLA-DQB1*0304 P
M25328.1 Homo sapiens MHC HLA-DBQ3 allele DQ1.2 mRNA, 5' end
M59800.1 Human MHC class II DQB1 mRNA (DQw1(w6)), partial cds P
M59801.1 Human MHC class II DQB1*0603 mRNA (DQw1(w6)), partial cds P
M57650.1 Human MHC HLA-Dw12 DQ-beta chain mRNA, 3' end P
M22550.1 Human MHC class II HLA-DQ beta mRNA (DR3,DQw), partial cds, clone 2041C72 P
M22549.1 Human MHC class II HLA-DQ beta mRNA (DR3,DQw), partial cds, clone 2041C77 P
M13279.1 Human MHC HLA-DR4 DQ-beta chain first variable domain mRNA, clone KT3c21 P
M83770.1 Human MHC class II HLA-DQ-beta mRNA (DQB1*0304) P
M20505.1 Human MHC class II HLA-DQ-beta mRNA, partial cds P
M32577.1 Human MHC HLA-DQ beta mRNA, complete cds P
M21135.1 Human MHC class II HLA-DQ-beta-I first domain mRNA (DR4,DQw3.2), partial cds P
M17565.1 Human MHC class II DQ-beta associated with DRw6, DQw1 protein, complete cds P
M35731.1 Human MHC class II DQ3.1LUY (DR8) mRNA, partial cds P
M35730.1 Human MHC class II DQ3.1ER (DR4) mRNA, partial cds P
M17204.1 Human MHC class II DQ-beta chain (Dw12) mRNA, partial cds from cell line BGE P
M17207.1 Human MHC class II DQ-beta chain (Dw2) mRNA, partial cds, from cell line PGF P
M17206.1 Human MHC class II DQ-beta chain (Dw12/non-Dw12) mRNA, partial cds, from cell line AZH P
M25327.1 Homo sapiens MHC HLA-DBQ3 allele DQw3.3 mRNA, 5' end P
M25326.1 Homo sapiens MHC HLA-DBQ3 allele DQw3.2 mRNA, 5' end P
M25325.1 Homo sapiens MHC HLA-DBQ3 allele DQw3.1 mRNA, 5' end P
M19239.1 Human MHC class II HLA-DQ-beta-I first domain mRNA (DRw6,DQw1.9), partial cds P
M14189.1 Human MHC class II DQ-beta chain mRNA (DR7), partial cds P
M35982.1 Human MHC class II HLA-DC-beta chain mRNA, 5' end
AK316333.1 Homo sapiens cDNA, FLJ79232 complete cds, highly similar to HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor PA
U83582.1 Human MHC class II HLA-DQ mRNA (HLA-DQB1*0301 allele), partial cds P
NM_001243962.1 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 3, mRNA PA
NM_001243961.1 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 2, mRNA PA
L42626.1 Homo sapiens MHC class II HLA-DQB1*0609 mRNA, partial cds P
L40179.1 Homo sapiens MHC class II HLA-DQB1*0201 mRNA, 3' end, exons 1-4 and 6 P
L40180.1 Homo sapiens (clone D2B EK5.4,5-6) MHC class II HLA-DQB1*05031 mRNA, 3' end, exons 1-6 P
L40181.1 Homo sapiens (clone D2B E418-3) MHC class II HLA-DQB1*06011 mRNA, 3' end, exons 1-6 P
X96420.1 H.sapiens mRNA for HLA-DQ beta chain P
U66400.1 Human MHC Class II HLA-DQB1*0301 variant (HLA-DQ) mRNA, partial cds P

EST sequences (10 of 485) [Show all sequences]

AA954889.1 Clone IMAGE:1576257 intestine 3' read A
AA961824.1 Clone IMAGE:1600296 uncharacterized tissue 3' read A
AA961950.1 Clone IMAGE:1593781 kidney 3' read A
AA988627.1 Clone IMAGE:1604730 lung 3' read A
AI004331.1 Clone IMAGE:1631863 mammary gland 3' read
R19164.1 Clone IMAGE:129888 mixed 3' read A
AI216648.1 Clone IMAGE:1883643 lung 3' read A
CB112679.1 Clone L6ChoCK0-6-C08 liver 5' read P
CB113827.1 Clone L6ChoCK0-21-H02 liver 5' read P
AI275169.1 Clone IMAGE:1990482 uterus 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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