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UGID:206222     UniGene Hs.386791     Homo sapiens (human)   PDE3A
Phosphodiesterase 3A, cGMP-inhibited (PDE3A)

Human protein-coding gene PDE3A. Represented by 112 ESTs from 66 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 206222 - Hs.386791]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000912.3 PDE3A gene product H. sapiens 100.0 1140
XP_520783.2 PREDICTED: cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform 2 P. troglodytes 99.8 1140
NP_061249.1 Pde3a gene product M. musculus 88.5 1140
XP_695432.3 PREDICTED: cGMP-inhibited 3',5'-cyclic phosphodiesterase A D. rerio 69.7 1039
NP_001088828.1 phosphodiesterase 3b, cGMP-inhibited X. laevis 60.4 936
NP_497084.2 Protein PDE-3, isoform a C. elegans 51.8 315
XP_001693675.1 3',5'-cyclic-nucleotide phosphodiesterase C. reinhardtii 48.6 177
Other hits (2 of 26) [Show all]SpeciesId(%)Len(aa)
XP_003906134.1 PREDICTED: cGMP-inhibited 3',5'-cyclic phosphodiesterase A P. anubis 99.3 1140
XP_001096963.2 PREDICTED: cGMP-inhibited 3',5'-cyclic phosphodiesterase A M. mulatta 98.3 1134

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: liver; placenta; embryonic tissue; muscle; pancreas; uncharacterized tissue; larynx; intestine; cervix; ear; brain; stomach; vascular; uterus; prostate; eye; mixed; connective tissue; testis; kidney; nerve; bone; ovary
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12p12
UniSTS entry: Chr 12 RH11286
UniSTS entry: Chr 12 SHGC-35793 [Map Viewer]
UniSTS entry: Chr 12 STS-M91667
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (8)

AJ005036.1 Homo sapiens mRNA for phosphodiesterase 3A (from corpus cavernosum) P
M91667.2 Homo sapiens cGMP-inhibited cAMP phosphodiesterase (PDE3A) mRNA, complete cds P
NM_000921.4 Homo sapiens phosphodiesterase 3A, cGMP-inhibited (PDE3A), transcript variant 1, mRNA PA
U36798.1 Homo sapiens platelet cGI-PDE mRNA, complete cds P
BC117371.1 Homo sapiens phosphodiesterase 3A, cGMP-inhibited, mRNA (cDNA clone MGC:150980 IMAGE:40125922), complete cds P
BC117369.1 Homo sapiens phosphodiesterase 3A, cGMP-inhibited, mRNA (cDNA clone MGC:150978 IMAGE:40125920), complete cds P
AK308317.1 Homo sapiens cDNA, FLJ98265 P
NM_001244683.1 Homo sapiens phosphodiesterase 3A, cGMP-inhibited (PDE3A), transcript variant 2, mRNA PA

EST sequences (10 of 112) [Show all sequences]

AI018052.1 Clone IMAGE:1642091 testis 3' read A
CB049641.1 Clone IMAGE:3271265 prostate 3' read A
CB049642.1 Clone IMAGE:3271265 prostate 5' read
CB050216.1 Clone IMAGE:3271884 prostate 5' read
CB050215.1 Clone IMAGE:3271884 prostate 3' read A
BX093899.1 Clone IMAGp998O17188_;_IMAGE:133864 placenta
AI249381.1 Clone IMAGE:2005105 pancreas 3' read A
R28512.1 Clone IMAGE:133864 placenta 5' read
R28660.1 Clone IMAGE:133864 placenta 3' read A
AI264257.1 Clone IMAGE:1869485 kidney 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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