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UGID:198867     UniGene Hs.370771     Homo sapiens (human)   CDKN1A
Cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A)

Human protein-coding gene CDKN1A. Represented by 1070 ESTs from 323 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 198867 - Hs.370771]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003950878.1 PREDICTED: cyclin-dependent kinase inhibitor 1 P. troglodytes 100.0 197
NP_000380.1 CDKN1A gene product H. sapiens 100.0 163
NP_001104569.1 Cdkn1a gene product M. musculus 78.6 158
Other hits (2 of 10) [Show all]SpeciesId(%)Len(aa)
XP_001116881.1 PREDICTED: cyclin-dependent kinase inhibitor 1-like isoform 9 M. mulatta 98.8 163
XP_003897576.1 PREDICTED: cyclin-dependent kinase inhibitor 1 isoform 1 P. anubis 98.8 163

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lung; skin; brain; pancreas; uncharacterized tissue; eye; placenta; connective tissue; embryonic tissue; larynx; stomach; uterus; intestine; lymph; vascular; epididymis; ascites; prostate; mammary gland; liver; trachea; thymus; mixed; testis; amniotic fluid; kidney; blood; heart; ear; adipose tissue; cervix; bone marrow; mouth; nerve; bone; muscle; ovary; lymph node; thyroid; bladder; salivary gland; pharynx; ganglia; parathyroid; esophagus
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 6
Map position: 6p21.2
UniSTS entry: Chr 6 D6S2036
UniSTS entry: Chr 6 PMC25807P2
UniSTS entry: Chr 6 GDB:607527
UniSTS entry: Chr 6 RH70551
UniSTS entry: GDB:606724
UniSTS entry: Chr 6 PMC133799P1
UniSTS entry: Chr 6 PMC310739P1
UniSTS entry: Chr 6 RH1534 [Map Viewer]
UniSTS entry: Chr 6 WI-7311 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (21)

BT006719.1 Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) mRNA, complete cds P
CR536533.1 Homo sapiens full open reading frame cDNA clone RZPDo834A0522D for gene CDKN1A, cyclin-dependent kinase inhibitor 1A (p21, Cip1); complete cds, incl. stopcodon P
L47232.1 Homo sapiens cyclin-dependent kinase (CIP1/WAF1) mRNA, with a mutation (Ser 31 to Arg) predisposing to cancer, 3' end P
L47233.1 Homo sapiens cyclin-dependent kinase (CIP1/WAF1) mRNA, 3' end, with a cancer predisposing mutation in the 3' UTR P
AB209881.1 Homo sapiens mRNA for Cyclin-dependent kinase variant protein P
L25610.1 Homo sapiens cyclin-dependent kinase inhibitor mRNA, complete cds P
U03106.1 Human wild-type p53 activated fragment-1 (WAF1) mRNA, complete cds PA
NM_000389.4 Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 1, mRNA PA
BC001935.1 Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1), mRNA (cDNA clone MGC:4059 IMAGE:2823668), complete cds PA
BC000312.2 Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1), mRNA (cDNA clone MGC:8428 IMAGE:2821049), complete cds PA
BC000275.1 Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1), mRNA (cDNA clone MGC:3175 IMAGE:3355833), complete cds PA
BC013967.2 Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1), mRNA (cDNA clone MGC:8559 IMAGE:2822909), complete cds PA
NM_078467.2 Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 2, mRNA PA
AK298901.1 Homo sapiens cDNA FLJ54803 complete cds, highly similar to Cyclin-dependent kinase inhibitor 1 P
AB451422.1 Homo sapiens CDKN1A mRNA for cyclin-dependent kinase inhibitor 1A, partial cds, clone: FLJ08131AAAF P
AB451290.1 Homo sapiens CDKN1A mRNA for cyclin-dependent kinase inhibitor 1A, complete cds, clone: FLJ08131AAAN P
U09579.1 Human melanoma differentiation associated (mda-6) mRNA, complete cds P
S67388.1 p21=cyclin kinase inhibitor [human, lung, WI38, mRNA, 600 nt] P
L26165.1 Human DNA synthesis inhibitor mRNA, complete cds P
NM_001220778.1 Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 4, mRNA PA
NM_001220777.1 Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 5, mRNA PA

EST sequences (10 of 1070) [Show all sequences]

AA962447.1 Clone IMAGE:1553570 kidney 3' read A
AA903331.1 Clone IMAGE:1516948 uncharacterized tissue 3' read A
AA972341.1 Clone IMAGE:1584548 lung 3' read A
AA977002.1 Clone IMAGE:1558697 lung 3' read A
AI018663.1 Clone IMAGE:1642206 testis 3' read A
AI041908.1 Clone IMAGE:1664590 skin 3' read
AI041930.1 Clone IMAGE:1664603 skin 3' read A
AI066427.1 Clone IMAGE:1594392 intestine 3' read A
AI073360.1 Clone IMAGE:1679381 skin 3' read A
AI077767.1 Clone IMAGE:1664510 skin 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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