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UGID:198284     UniGene Hs.369779     Homo sapiens (human)   SIRT1
Sirtuin 1 (SIRT1)

Human protein-coding gene SIRT1. Represented by 121 ESTs from 89 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 198284 - Hs.369779]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_036370.2 SIRT1 gene product H. sapiens 100.0 746
XP_003312628.1 PREDICTED: NAD-dependent deacetylase sirtuin-1 isoform 1 P. troglodytes 99.9 750
NP_062786.1 Sirt1 gene product M. musculus 94.3 736
NP_001091195.1 sirtuin 1 X. laevis 79.6 668
XP_001334440.4 PREDICTED: NAD-dependent deacetylase sirtuin-1 D. rerio 75.7 650
NP_477351.1 Sir2 D. melanogaster 57.3 506
NP_001255485.1 Protein SIR-2.1, isoform b C. elegans 48.5 373
XP_960372.1 hypothetical protein NCU04737 N. crassa 48.4 221
NP_014573.1 Hst1p S. cerevisiae 46.1 165
Other hits (2 of 41) [Show all]SpeciesId(%)Len(aa)
XP_003903926.1 PREDICTED: NAD-dependent protein deacetylase sirtuin-1 P. anubis 98.9 742
XP_001087854.2 PREDICTED: NAD-dependent deacetylase sirtuin-1 M. mulatta 97.2 712

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: intestine; lung; adrenal gland; pituitary gland; brain; ear; mixed; pancreas; testis; mammary gland; uterus; lymph node; embryonic tissue; placenta; muscle; bone; spleen; kidney; lymph; trachea; thymus; prostate; uncharacterized tissue; liver; vascular; skin; cervix; eye; tonsil; salivary gland; parathyroid
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10q21.3
UniSTS entry: Chr 10 RH66167 [Map Viewer]
UniSTS entry: Chr 10 STS-H98832
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

BX648554.1 Homo sapiens mRNA; cDNA DKFZp779P1254 (from clone DKFZp779P1254) PA
NM_012238.4 Homo sapiens sirtuin 1 (SIRT1), transcript variant 1, mRNA P
AF083106.2 Homo sapiens sirtuin type 1 (SIRT1) mRNA, complete cds P
AF235040.1 Homo sapiens SIR2alpha protein (SIR2ALPHA) mRNA, complete cds P
AL136741.1 Homo sapiens mRNA; cDNA DKFZp434F1411 (from clone DKFZp434F1411) PA
AK027686.1 Homo sapiens cDNA FLJ14780 fis, clone NT2RP4000449, highly similar to NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) P
BC012499.1 Homo sapiens sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), mRNA (cDNA clone MGC:21066 IMAGE:4518906), complete cds PA
AK289743.1 Homo sapiens cDNA FLJ76335 complete cds, highly similar to Homo sapiens sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), mRNA P
AK074805.1 Homo sapiens cDNA FLJ90324 fis, clone NT2RP2001817, highly similar to NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) P
NM_001142498.1 Homo sapiens sirtuin 1 (SIRT1), transcript variant 2, mRNA P
JQ768366.1 Homo sapiens sirtuin 1 (SIRT1) mRNA, partial cds P

EST sequences (10 of 121) [Show all sequences]

AA971929.1 Clone IMAGE:1583297 mixed 3' read A
BX105044.1 Clone IMAGp998G191162 uterus 5' read
AI217748.1 Clone IMAGE:1845234 mixed 3' read
AI282390.1 Clone IMAGE:1982123 lymph node 3' read A
AI367389.1 Clone IMAGE:1989369 uterus 3' read A
AI378978.1 Clone IMAGE:2067083 embryonic tissue 3' read
AI381553.1 Clone IMAGE:2092647 mixed 3' read A
AI751813.1 Clone NHTBC_cn12a08 bone
AI751814.1 Clone NHTBC_cn12a08 bone P
AI807525.1 Clone IMAGE:2358872 mixed 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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