NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
Finding cDNAs

UGID:198284     UniGene Hs.369779     Homo sapiens (human)   SIRT1
Sirtuin 1 (SIRT1)

Human protein-coding gene SIRT1. Represented by 121 ESTs from 89 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 198284 - Hs.369779]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_036370.2 SIRT1 gene product H. sapiens 100.0 746
XP_003312628.1 PREDICTED: NAD-dependent deacetylase sirtuin-1 isoform 1 P. troglodytes 99.9 750
NP_062786.1 Sirt1 gene product M. musculus 94.3 736
NP_001091195.1 sirtuin 1 X. laevis 79.6 668
XP_001334440.4 PREDICTED: NAD-dependent deacetylase sirtuin-1 D. rerio 75.7 650
NP_477351.1 Sir2 D. melanogaster 57.3 506
NP_001255485.1 Protein SIR-2.1, isoform b C. elegans 48.5 373
XP_960372.1 hypothetical protein NCU04737 N. crassa 48.4 221
NP_014573.1 Hst1p S. cerevisiae 46.1 165
Other hits (2 of 41) [Show all]SpeciesId(%)Len(aa)
XP_003903926.1 PREDICTED: NAD-dependent protein deacetylase sirtuin-1 P. anubis 98.9 742
XP_001087854.2 PREDICTED: NAD-dependent deacetylase sirtuin-1 M. mulatta 97.2 712

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: intestine; lung; adrenal gland; pituitary gland; brain; ear; mixed; pancreas; testis; mammary gland; uterus; lymph node; embryonic tissue; placenta; muscle; bone; spleen; kidney; lymph; trachea; thymus; prostate; uncharacterized tissue; liver; vascular; skin; cervix; eye; tonsil; salivary gland; parathyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10q21.3
UniSTS entry: Chr 10 RH66167 [Map Viewer]
UniSTS entry: Chr 10 STS-H98832
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

BX648554.1 Homo sapiens mRNA; cDNA DKFZp779P1254 (from clone DKFZp779P1254) PA
NM_012238.4 Homo sapiens sirtuin 1 (SIRT1), transcript variant 1, mRNA P
AF083106.2 Homo sapiens sirtuin type 1 (SIRT1) mRNA, complete cds P
AF235040.1 Homo sapiens SIR2alpha protein (SIR2ALPHA) mRNA, complete cds P
AL136741.1 Homo sapiens mRNA; cDNA DKFZp434F1411 (from clone DKFZp434F1411) PA
AK027686.1 Homo sapiens cDNA FLJ14780 fis, clone NT2RP4000449, highly similar to NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) P
BC012499.1 Homo sapiens sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), mRNA (cDNA clone MGC:21066 IMAGE:4518906), complete cds PA
AK289743.1 Homo sapiens cDNA FLJ76335 complete cds, highly similar to Homo sapiens sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), mRNA P
AK074805.1 Homo sapiens cDNA FLJ90324 fis, clone NT2RP2001817, highly similar to NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) P
NM_001142498.1 Homo sapiens sirtuin 1 (SIRT1), transcript variant 2, mRNA P
JQ768366.1 Homo sapiens sirtuin 1 (SIRT1) mRNA, partial cds P

EST sequences (10 of 121) [Show all sequences]

AA971929.1 Clone IMAGE:1583297 mixed 3' read A
BX105044.1 Clone IMAGp998G191162 uterus 5' read
AI217748.1 Clone IMAGE:1845234 mixed 3' read
AI282390.1 Clone IMAGE:1982123 lymph node 3' read A
AI367389.1 Clone IMAGE:1989369 uterus 3' read A
AI378978.1 Clone IMAGE:2067083 embryonic tissue 3' read
AI381553.1 Clone IMAGE:2092647 mixed 3' read A
AI751813.1 Clone NHTBC_cn12a08 bone
AI751814.1 Clone NHTBC_cn12a08 bone P
AI807525.1 Clone IMAGE:2358872 mixed 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help