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UGID:198183     UniGene Hs.369607     Homo sapiens (human)   GAK
Cyclin G associated kinase (GAK)

Human protein-coding gene GAK. Represented by 452 ESTs from 221 cDNA libraries. Corresponds to reference sequence NM_005255.2. [UniGene 198183 - Hs.369607]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_005246.2 GAK gene product H. sapiens 100.0 1310
XP_001140835.1 PREDICTED: cyclin-G-associated kinase isoform 9 P. troglodytes 99.9 1310
NP_705797.1 Gak gene product M. musculus 91.3 1304
XP_001919224.1 PREDICTED: cyclin-G-associated kinase-like isoform 2 D. rerio 79.7 1277
NP_649438.1 auxillin, isoform B D. melanogaster 52.2 423
Other hits (2 of 40) [Show all]SpeciesId(%)Len(aa)
XP_003890983.1 PREDICTED: cyclin-G-associated kinase P. anubis 98.2 1271
XP_001094120.2 PREDICTED: cyclin-G-associated kinase M. mulatta 98.2 1721

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; intestine; uncharacterized tissue; lung; placenta; cervix; eye; skin; blood; adipose tissue; embryonic tissue; mixed; kidney; stomach; thymus; uterus; pancreas; trachea; parathyroid; liver; bladder; ascites; mouth; salivary gland; ovary; lymph node; pituitary gland; nerve; mammary gland; prostate; muscle; adrenal gland; spleen; connective tissue; bone; thyroid; heart; lymph
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 4
Map position: 4p16
UniSTS entry: Chr 4 SHGC-68043 [Map Viewer]
UniSTS entry: Chr 4 WI-20233 [Map Viewer]
UniSTS entry: Chr 4 GAK__6772
UniSTS entry: Chr 1 GDB:434012
UniSTS entry: Chr 1 L17705
UniSTS entry: Chr 1 sY3084
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (16)

BT007015.1 Homo sapiens cyclin G associated kinase mRNA, complete cds P
AK127351.1 Homo sapiens cDNA FLJ45425 fis, clone BRHIP3037543, moderately similar to Homo sapiens cyclin G associated kinase (GAK) P
AK126735.1 Homo sapiens cDNA FLJ44781 fis, clone BRACE3036283, moderately similar to Cyclin G-associated kinase (EC 2.7.1.-) P
NM_005255.2 Homo sapiens cyclin G associated kinase (GAK), mRNA PA
BC063606.1 Homo sapiens cyclin G associated kinase, mRNA (cDNA clone IMAGE:4938651), complete cds PA
BC085005.1 Homo sapiens cyclin G associated kinase, mRNA (cDNA clone MGC:99654 IMAGE:6598984), complete cds PA
AB208854.1 Homo sapiens mRNA for Cyclin G-associated kinase variant protein P
BC107076.1 Homo sapiens cyclin G associated kinase, mRNA (cDNA clone IMAGE:40027047), partial cds P
BC000816.1 Homo sapiens, clone IMAGE:3453673, mRNA, partial cds PA
BC008668.1 Homo sapiens cyclin G associated kinase, mRNA (cDNA clone IMAGE:3875773), complete cds PA
AK309413.1 Homo sapiens cDNA, FLJ99454 P
AK097714.1 Homo sapiens cDNA FLJ40395 fis, clone TESTI2036965, highly similar to Cyclin G-associated kinase (EC 2.7.11.1) P
AK092587.1 Homo sapiens cDNA FLJ35268 fis, clone PROST2005285 P
AK299554.1 Homo sapiens cDNA FLJ58258 complete cds, highly similar to Cyclin G-associated kinase (EC 2.7.11.1) PA
BC001290.1 Homo sapiens cyclin G associated kinase, mRNA (cDNA clone IMAGE:3455823) P
D88435.1 Homo sapiens mRNA for HsGAK, complete cds P

EST sequences (10 of 452) [Show all sequences]

AA968924.1 Clone IMAGE:1579093 mixed 3' read A
AI017176.1 Clone IMAGE:1627579 mixed 3' read PA
AI042020.1 Clone IMAGE:1667781 parathyroid 3' read PA
AI051490.1 Clone IMAGE:1659066 embryonic tissue 3' read A
AI090518.1 Clone IMAGE:1692116 heart 3' read P
AI138676.1 Clone IMAGE:1709915 heart 3' read A
AI140641.1 Clone IMAGE:1739706 lung 3' read
BX094508.1 Clone IMAGp998M201724_;_IMAGE:704443 lymph node P
AI190739.1 Clone IMAGE:1733940 testis 3' read A
AI205339.1 Clone IMAGE:1952990 brain 3' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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