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UGID:193761     UniGene Hs.350321     Homo sapiens (human)   RET
Ret proto-oncogene (RET)

Human protein-coding gene RET. Represented by 119 ESTs from 41 cDNA libraries. EST representation biased toward primitive neuroectodermal tumor of the CNS; juvenile. Corresponds to 2 reference sequences (different isoforms). [UniGene 193761 - Hs.350321]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_066124.1 RET gene product H. sapiens 100.0 1113
NP_033076.2 Ret gene product M. musculus 88.8 1114
NP_001079092.1 ret proto-oncogene precursor X. laevis 76.3 1046
NP_858048.2 ret gene product D. rerio 74.6 1095
NP_732286.1 heartless, isoform A D. melanogaster 51.0 296
NP_504459.1 Protein C24G6.2, isoform b C. elegans 50.3 147
Other hits (2 of 42) [Show all]SpeciesId(%)Len(aa)
XP_003903612.1 PREDICTED: proto-oncogene tyrosine-protein kinase receptor Ret P. anubis 98.7 1114
XP_003312612.1 PREDICTED: proto-oncogene tyrosine-protein kinase receptor Ret P. troglodytes 98.5 1080

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: primitive neuroectodermal tumor of the CNS [show more like this]
juvenile [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: uncharacterized tissue; brain; mixed; mammary gland; liver; embryonic tissue; heart; pancreas; eye; testis; blood; prostate; kidney; nerve; adrenal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10q11.2
UniSTS entry: Chr 10 RH66458 [Map Viewer]
UniSTS entry: Chr 10 GDB:592843
UniSTS entry: Chr 10 GDB:574049
UniSTS entry: Chr 10 GDB:193843
UniSTS entry: Chr 10 GDB:281473
UniSTS entry: Chr 10 G59921
UniSTS entry: Chr 10 D10S1566 [Map Viewer]
UniSTS entry: Chr 10 STS-T15350 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

AJ844649.1 Homo sapiens partial mRNA for receptor tyrosine kinase (RET gene), 3'UTR
NM_020630.4 Homo sapiens ret proto-oncogene (RET), transcript variant 4, mRNA PA
NM_020975.4 Homo sapiens ret proto-oncogene (RET), transcript variant 2, mRNA PA
BC004257.1 Homo sapiens ret proto-oncogene, mRNA (cDNA clone MGC:10752 IMAGE:3160389), complete cds PA
BC003072.2 Homo sapiens ret proto-oncogene, mRNA (cDNA clone IMAGE:3507569), complete cds PA
AK291807.1 Homo sapiens cDNA FLJ76670 complete cds, highly similar to Homo sapiens ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) (RET), transcript variant 4, mRNA P
AK294827.1 Homo sapiens cDNA FLJ58503 complete cds, highly similar to Proto-oncogene tyrosine-protein kinase receptorret precursor (EC 2.7.10.1) P
Y12528.1 H.sapiens ret mRNA, partial P
X15262.1 Human mRNA for ret proto-oncogene 5'-end P
AB698668.1 Homo sapiens CCDC6-RETa mRNA for CCDC6-RET fusion protein variant a, complete cds P
AB698669.1 Homo sapiens CCDC6-RETc mRNA for CCDC6-RET fusion protein variant c, complete cds P

EST sequences (10 of 119) [Show all sequences]

AA983685.1 Clone IMAGE:1507745 mixed 3' read
CB050374.1 Clone IMAGE:3271933 prostate 3' read
AI167534.1 Clone IMAGE:1661436 mixed 3' read A
AI263439.1 Clone IMAGE:1855723 mixed 3' read A
AA903339.1 Clone IMAGE:1516955 uncharacterized tissue 3' read A
AI204150.1 Clone IMAGE:1734822 testis 3' read A
AI472270.1 Clone IMAGE:2147933 mixed 3' read A
BX283168.1 Clone IMAGp958B21185_;_IMAGE:3506612 kidney P
BX283511.1 Clone IMAGp958H13189_;_IMAGE:3508284 brain P
AI825524.1 Clone IMAGE:2306066 uncharacterized tissue 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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