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UGID:193757     UniGene Hs.350265     Homo sapiens (human)   LONP1
Lon peptidase 1, mitochondrial (LONP1)

Human protein-coding gene LONP1. Represented by 969 ESTs from 307 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 193757 - Hs.350265]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_004784.2 LONP1 gene product H. sapiens 100.0 958
XP_001143873.1 PREDICTED: lon protease homolog, mitochondrial isoform 3 P. troglodytes 99.9 958
NP_083058.2 Lonp1 gene product M. musculus 94.2 948
XP_691712.4 PREDICTED: lon peptidase 1, mitochondrial D. rerio 89.7 961
NP_649133.1 Lon protease, isoform A D. melanogaster 76.9 921
NP_492796.1 Protein C34B2.6 C. elegans 68.7 894
NP_568490.3 lon protease 1 A. thaliana 65.0 895
XP_961826.1 ATP-dependent protease La N. crassa 63.7 981
NP_009531.1 Pim1p S. cerevisiae 62.6 775
NP_001089948.1 lon protease homolog 2, peroxisomal X. laevis 54.0 562
Other hits (2 of 62) [Show all]SpeciesId(%)Len(aa)
XP_003914772.1 PREDICTED: lon protease homolog, mitochondrial isoform 1 P. anubis 99.5 963
XP_001088663.2 PREDICTED: lon protease homolog, mitochondrial-like M. mulatta 98.7 1097

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; skin; testis; lung; uncharacterized tissue; liver; placenta; intestine; uterus; lymph; eye; kidney; embryonic tissue; prostate; trachea; ovary; cervix; mouth; bladder; tonsil; ascites; blood; mammary gland; thymus; stomach; thyroid; connective tissue; adrenal gland; lymph node; pharynx; muscle; salivary gland; pancreas; mixed; ganglia; spleen; heart; bone; bone marrow; umbilical cord; esophagus; vascular; adipose tissue; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19p13.2
UniSTS entry: Chr 19 LONP1
UniSTS entry: RH143400
UniSTS entry: Chr 1 D8S2278
UniSTS entry: Chr 1 D11S2921
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (15)

AK127867.1 Homo sapiens cDNA FLJ45970 fis, clone PLACE7016526, highly similar to Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) P
NM_004793.3 Homo sapiens lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA PA
BC109219.1 Homo sapiens cDNA clone IMAGE:40008125, containing frame-shift errors P
BC109218.1 Homo sapiens lon peptidase 1, mitochondrial, mRNA (cDNA clone IMAGE:40008118), partial cds P
BC000235.1 Homo sapiens lon peptidase 1, mitochondrial, mRNA (cDNA clone MGC:1498 IMAGE:3350958), complete cds PA
U02389.1 Human hLON ATP-dependent protease mRNA, nuclear gene encoding mitochondrial protein, complete cds P
BC139726.1 Homo sapiens lon peptidase 1, mitochondrial, mRNA (cDNA clone IMAGE:40017643), partial cds P
AK056366.1 Homo sapiens cDNA FLJ31804 fis, clone NT2RI2009103, highly similar to Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) P
AK309720.1 Homo sapiens cDNA, FLJ99761 PA
AK096626.1 Homo sapiens cDNA FLJ39307 fis, clone OCBBF2013208, highly similar to MITOCHONDRIAL LON PROTEASE PRECURSOR (EC 3.4.21.-) P
AK096433.1 Homo sapiens cDNA FLJ39114 fis, clone NTONG2006099, highly similar to Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) P
AK298531.1 Homo sapiens cDNA FLJ56219 complete cds, highly similar to Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) PA
NR_076392.1 Homo sapiens lon peptidase 1, mitochondrial (LONP1), transcript variant 4, non-coding RNA A
NM_001276479.1 Homo sapiens lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA A
NM_001276480.1 Homo sapiens lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA A

EST sequences (10 of 969) [Show all sequences]

AA954697.1 Clone IMAGE:1554957 kidney 3' read A
AA908941.1 Clone IMAGE:1523086 mixed 3' read P
AI004552.1 Clone IMAGE:1620358 testis 3' read PA
R18932.1 Clone IMAGE:33075 brain 5' read
R19903.1 Clone IMAGE:34915 brain 5' read
AI082247.1 Clone IMAGE:1662594 mixed 3' read A
AI093183.1 Clone IMAGE:1694782 heart 3' read PA
AI129401.1 Clone IMAGE:1711916 uterus 3' read PA
AI206239.1 Clone IMAGE:1941626 uncharacterized tissue 3' read P
CB106605.1 Clone L3SNU475-6-D04 liver 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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