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UGID:136257     UniGene Hs.34314     Homo sapiens (human)   MARK4
MAP/microtubule affinity-regulating kinase 4 (MARK4)

Human protein-coding gene MARK4. Represented by 236 ESTs from 132 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 136257 - Hs.34314]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003915754.1 PREDICTED: MAP/microtubule affinity-regulating kinase 4 isoform 1 P. anubis 100.0 751
XP_512745.3 PREDICTED: MAP/microtubule affinity-regulating kinase 4 isoform 2 P. troglodytes 100.0 751
NP_001186796.1 MARK4 gene product H. sapiens 100.0 751
NP_001030436.1 MARK4 gene product B. taurus 99.5 441
NP_758483.1 MAP/microtubule affinity-regulating kinase 4 M. musculus 99.1 751
XP_699946.3 PREDICTED: MAP/microtubule affinity-regulating kinase 4-like D. rerio 84.5 778
NP_001084256.1 MAP/microtubule affinity-regulating kinase 3 X. laevis 78.2 724
NP_001246422.1 par-1, isoform U D. melanogaster 70.2 691
NP_001256565.1 Protein PAR-1, isoform e C. elegans 69.5 642
XP_958665.2 hypothetical protein NCU04566 N. crassa 55.9 263
NP_974375.1 SNF1-related protein kinase catalytic subunit alpha KIN11 A. thaliana 54.0 313
NP_010765.3 Snf1p S. cerevisiae 52.9 331
XP_001698727.1 hypothetical protein CHLREDRAFT_106184 C. reinhardtii 48.1 283
Other hits (2 of 61) [Show all]SpeciesId(%)Len(aa)
XP_001105523.2 PREDICTED: MAP/microtubule affinity-regulating kinase 4 M. mulatta 99.5 721
XP_541564.4 PREDICTED: MAP/microtubule affinity-regulating kinase 4 C. lupus familiaris 99.3 735

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; uncharacterized tissue; testis; eye; embryonic tissue; mixed; pancreas; ovary; lymph node; lung; mammary gland; stomach; muscle; vascular; placenta; heart; blood; kidney; cervix; thyroid; bladder; intestine; thymus; spleen; bone marrow; skin; uterus; prostate; connective tissue; lymph; salivary gland; mouth; liver; ganglia; bone; pineal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19q13.3
UniSTS entry: Chr 19 D19S1105 [Map Viewer]
UniSTS entry: Chr 19 G20412
UniSTS entry: Chr 19 A005Q13 [Map Viewer]
UniSTS entry: Chr 19 SGC30757 [Map Viewer]
UniSTS entry: Chr 19 D19S1005 [Map Viewer]
UniSTS entry: Chr 19 MARK4__7374
UniSTS entry: Chr 1 D11S3114
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

AB073663.1 Homo sapiens primary neuroblastoma cDNA, clone:Nbla00650, full insert sequence P
AB049127.1 Homo sapiens MARKL1 mRNA for MAP/microtubule affinity-regulating kinase like 1, complete cds P
AK027619.1 Homo sapiens cDNA FLJ14713 fis, clone NT2RP3000845, moderately similar to PUTATIVE SERINE/THREONINE-PROTEIN KINASE P78 (EC 2.7.1.-) P
AB058763.1 Homo sapiens mRNA for KIAA1860 protein, partial cds P
NM_031417.3 Homo sapiens MAP/microtubule affinity-regulating kinase 4 (MARK4), transcript variant 2, mRNA P
BC009049.2 Homo sapiens MAP/microtubule affinity-regulating kinase 4, mRNA (cDNA clone IMAGE:3874322), complete cds PA
AY057448.1 Homo sapiens MARK4 serine/threonine protein kinase mRNA, complete cds P
AB088047.1 Homo sapiens MARKL1L mRNA for microtubule affinity-regulating kinase-like1, complete cds P
AK075272.1 Homo sapiens cDNA FLJ90791 fis, clone THYRO1001593, moderately similar to PUTATIVE SERINE/THREONINE-PROTEIN KINASE P78 (EC 2.7.1.-) P
AK074578.1 Homo sapiens cDNA FLJ90097 fis, clone HEMBA1005929, weakly similar to H.sapiens mRNA for serine/threonine protein kinase EMK P
NM_001199867.1 Homo sapiens MAP/microtubule affinity-regulating kinase 4 (MARK4), transcript variant 1, mRNA P
AY120867.1 Homo sapiens MAP/microtubule affinity-regulating kinase-like 1 (MARK4) mRNA, MARK4-L allele, complete cds; alternatively spliced P

EST sequences (10 of 236) [Show all sequences]

R14738.1 Clone IMAGE:29727 brain 5' read
AA928937.1 Clone IMAGE:1567776 lung 3' read A
AI082139.1 Clone IMAGE:1640096 testis 3' read
AA907088.1 Clone IMAGE:1522349 lung 3' read
AI125671.1 Clone IMAGE:1736784 testis 3' read
AI142585.1 Clone IMAGE:1509789 mixed 3' read
BX116067.1 Clone IMAGp998N06240_;_IMAGE:153797 mammary gland
AI202873.1 Clone IMAGE:1860453 brain 3' read PA
AI240679.1 Clone IMAGE:1848396 mixed 3' read A
AI272168.1 Clone IMAGE:1956016 brain 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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