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UGID:136230     UniGene Hs.34012     Homo sapiens (human)   BRCA2
Breast cancer 2, early onset (BRCA2)

Human protein-coding gene BRCA2. Represented by 71 ESTs from 45 cDNA libraries. Corresponds to reference sequence NM_000059.3. [UniGene 136230 - Hs.34012]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000050.2 BRCA2 gene product H. sapiens 100.0 3417
NP_001074470.1 Brca2 gene product M. musculus 62.9 3293
NP_001103864.2 brca2 gene product D. rerio 59.0 393
Other hits (2 of 22) [Show all]SpeciesId(%)Len(aa)
XP_509619.2 PREDICTED: breast cancer type 2 susceptibility protein P. troglodytes 99.2 3417
XP_003913789.1 PREDICTED: LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein P. anubis 94.3 3421

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: eye; liver; pancreas; mammary gland; testis; lymph node; bone marrow; embryonic tissue; thyroid; intestine; mouth; uncharacterized tissue; pharynx; mixed; brain; kidney; lung; vascular; placenta; bladder; connective tissue; ascites
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 13
Map position: 13q12.3
UniSTS entry: Chr 13 D13S1788
UniSTS entry: Chr 13 SHGC-81356
UniSTS entry: Chr 13 BRCA2
UniSTS entry: Chr 13 RH68440 [Map Viewer]
UniSTS entry: Chr 13 PMC23830P1
UniSTS entry: Chr 13 PMC310899P14
UniSTS entry: Chr 13 PMC13918P4
UniSTS entry: Chr 13 PMC13918P2
UniSTS entry: Chr 13 PMC13918P3
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (4)

BC047568.1 Homo sapiens breast cancer 2, early onset, mRNA (cDNA clone IMAGE:4838724) PA
NM_000059.3 Homo sapiens breast cancer 2, early onset (BRCA2), mRNA P
DQ897648.1 Homo sapiens breast and ovarian cancer susceptibility protein 2 truncated variant (BRCA2) mRNA, complete cds, alternatively spliced P
BC026160.1 Homo sapiens breast cancer 2, early onset, mRNA (cDNA clone IMAGE:4838723) PA

EST sequences (10 of 71) [Show all sequences]

BX102368.1 Clone IMAGp998N09367_;_IMAGE:193736 mixed P
AI343430.1 Clone IMAGE:2062194 intestine 3' read P
AI355687.1 Clone IMAGE:1952009 lung 3' read P
AI439788.1 Clone IMAGE:2134444 lymph node 3' read P
AI688632.1 Clone IMAGE:2330588 mixed 3' read P
AL044849.1 Clone DKFZp434D113 testis 5' read
AI949397.1 Clone IMAGE:2470940 kidney 3' read P
BX496533.1 Clone DKFZp779P2327 liver 5' read P
CD705611.1 pharynx P
CF143354.1 Clone IMAGE:3102360 lymph node 5' read P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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