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UGID:192057     UniGene Hs.338207     Homo sapiens (human)   MTOR
Mechanistic target of rapamycin (serine/threonine kinase) (MTOR)

Human protein-coding gene MTOR. Represented by 401 ESTs from 187 cDNA libraries. Corresponds to reference sequence NM_004958.3. [UniGene 192057 - Hs.338207]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_004949.1 MTOR gene product H. sapiens 100.0 2548
XP_002694089.1 PREDICTED: serine/threonine-protein kinase mTOR B. taurus 99.9 2550
XP_001492401.1 PREDICTED: serine/threonine-protein kinase mTOR E. caballus 99.8 2549
NP_001138927.1 MTOR gene product O. aries 99.8 2549
XP_003891156.1 PREDICTED: serine/threonine-protein kinase mTOR P. anubis 99.8 2561
XP_535407.3 PREDICTED: serine/threonine-protein kinase mTOR isoform 1 C. lupus familiaris 99.7 2545
XP_003127632.3 PREDICTED: serine/threonine-protein kinase mTOR S. scrofa 99.7 2547
NP_064393.2 Mtor gene product M. musculus 99.5 2548
NP_001070679.2 mtor gene product D. rerio 93.4 2513
XP_001697578.1 target of rapamycin, growth-regulatory PI3K-like protein kinase C. reinhardtii 64.7 848
NP_524891.1 target of rapamycin, isoform A D. melanogaster 62.9 2468
XP_960570.1 phosphatidylinositol 3-kinase tor2 N. crassa 61.4 1328
NP_001117459.1 FKBP12-rapamycin complex-associated protein A. thaliana 60.0 1831
NP_491552.2 Protein LET-363, isoform b C. elegans 59.5 1077
NP_012719.2 Tor2p S. cerevisiae 59.0 1257
Other hits (2 of 53) [Show all]SpeciesId(%)Len(aa)
NP_063971.1 Mtor gene product R. norvegicus 99.5 2548
XP_002723399.1 PREDICTED: FK506 binding protein 12-rapamycin associated protein 1 O. cuniculus 99.5 2542

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; skin; testis; mixed; placenta; liver; prostate; lymph node; uterus; kidney; lung; eye; thymus; uncharacterized tissue; embryonic tissue; mouth; intestine; mammary gland; pancreas; thyroid; muscle; blood; larynx; bone marrow; lymph; spleen; trachea; connective tissue; ascites; heart; bone; pharynx; ovary; cervix; vascular; adipose tissue; parathyroid; esophagus; epididymis
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 1
Map position: 1p36.2
UniSTS entry: Chr 1 RH25957
UniSTS entry: Chr 1 SHGC-74214 [Map Viewer]
UniSTS entry: Chr 1 G60252
UniSTS entry: Chr 1 G60245
UniSTS entry: Chr 1 SHGC-12595 [Map Viewer]
UniSTS entry: Chr 1 SHGC-132097
UniSTS entry: Chr 1 MARC_21302-21303:1032900670:1
UniSTS entry: Chr 1 D11S3114
UniSTS entry: Chr 1 GDB:434012
UniSTS entry: Chr 1 D1S1423
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

U88966.1 Human protein rapamycin associated protein (FRAP2) gene, complete cds PA
AK126762.1 Homo sapiens cDNA FLJ44809 fis, clone BRACE3044172, highly similar to FKBP12-rapamycin complex-associated protein P
NM_004958.3 Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) (MTOR), mRNA PA
L34075.1 Human FKBP-rapamycin associated protein (FRAP) mRNA, complete cds P
AB209995.1 Homo sapiens mRNA for FRAP1 variant protein, partial cds, clone: ef01094 P
AK024393.1 Homo sapiens cDNA FLJ14331 fis, clone PLACE4000320
BC113820.1 Homo sapiens cDNA clone IMAGE:40022751, with apparent retained intron
BC117166.1 Homo sapiens FK506 binding protein 12-rapamycin associated protein 1, mRNA (cDNA clone MGC:150775 IMAGE:40125717), complete cds P
BC127611.1 Homo sapiens cDNA clone IMAGE:40031732, partial cds
AK304273.1 Homo sapiens cDNA FLJ56559 complete cds, highly similar to FKBP12-rapamycin complex-associated protein PA
AK302863.1 Homo sapiens cDNA FLJ60991 complete cds, highly similar to FKBP12-rapamycin complex-associated protein PA
L35478.1 Homo sapiens RAPT1 (RAPT1) mRNA, partial cds P

EST sequences (10 of 401) [Show all sequences]

AA976505.1 Clone IMAGE:1587826 uncharacterized tissue 3' read A
R08551.1 Clone IMAGE:127374 mixed 3' read A
AA975907.1 Clone IMAGE:1567970 lung 3' read A
R17742.1 Clone IMAGE:25287 brain 3' read A
AI025628.1 Clone IMAGE:1645842 parathyroid 3' read A
AI027283.1 Clone IMAGE:1644854 testis 3' read A
T05942.1 Clone HFBDI90 brain P
R20499.1 Clone IMAGE:35640 brain 5' read
AI076313.1 Clone IMAGE:1673578 mixed 3' read A
AI090968.1 Clone IMAGE:1690403 mixed 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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