NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
Finding cDNAs

UGID:136134     UniGene Hs.32959     Homo sapiens (human)   GRK4
G protein-coupled receptor kinase 4 (GRK4)

Human protein-coding gene GRK4. Represented by 78 ESTs from 30 cDNA libraries. EST representation biased toward fetus. Corresponds to 3 reference sequences (different isoforms). [UniGene 136134 - Hs.32959]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_892027.2 GRK4 gene product H. sapiens 100.0 577
NP_001086996.1 G protein-coupled receptor kinase 4 X. laevis 82.1 571
NP_062370.2 Grk4 gene product M. musculus 81.5 573
NP_001073455.1 grk4 gene product D. rerio 80.7 559
NP_476867.1 G protein-coupled receptor kinase 2, isoform A D. melanogaster 72.8 423
NP_509676.1 Protein GRK-1 C. elegans 60.8 595
Other hits (2 of 36) [Show all]SpeciesId(%)Len(aa)
XP_001152424.1 PREDICTED: G protein-coupled receptor kinase 4 isoform 7 P. troglodytes 99.1 577
XP_003890915.1 PREDICTED: G protein-coupled receptor kinase 4 isoform 1 P. anubis 96.7 577

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: fetus [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: testis; brain; mixed; eye; bone; connective tissue; adrenal gland; kidney; placenta; pancreas; lung; heart; pharynx; mammary gland; parathyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 4
Map position: 4p16.3
UniSTS entry: Chr 4 STS-N23898 [Map Viewer]
UniSTS entry: Chr 4 STS-AA024498
UniSTS entry: Chr 1 L18426
UniSTS entry: Chr 1 D1S1423
UniSTS entry: Chr 1 PMC156606P2
UniSTS entry: Chr 1 PMC156606P3
UniSTS entry: Chr 1 PMC156606P4
UniSTS entry: Chr 1 D8S2278
UniSTS entry: Chr 1 RH65222 [Map Viewer]
UniSTS entry: Chr 4 RH70602
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

NM_182982.2 Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 1, mRNA PA
BC063678.1 Homo sapiens cDNA clone IMAGE:4363166, partial cds A
NM_001004057.1 Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 3, mRNA PA
NM_001004056.1 Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 2, mRNA PA
U33054.1 Human G protein-coupled receptor kinase GRK4 mRNA, alpha splice variant, complete cds P
U33055.1 Human G protein-coupled receptor kinase GRK4 mRNA, beta splice variant, complete cds P
U33056.1 Human G protein-coupled receptor kinase GRK4 mRNA, gamma splice variant, complete cds P
AK223581.1 Homo sapiens mRNA for G protein-coupled receptor kinase 2-like isoform 2 variant, clone: FCC130B05 PA
BC117320.1 Homo sapiens G protein-coupled receptor kinase 4, mRNA (cDNA clone MGC:150929 IMAGE:40125871), complete cds P
AK055721.1 Homo sapiens cDNA FLJ31159 fis, clone KIDNE1000012
AK292390.1 Homo sapiens cDNA FLJ76938 complete cds, highly similar to Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 1, mRNA PA
AK293569.1 Homo sapiens cDNA FLJ57709 complete cds
BC027597.1 Homo sapiens cDNA clone IMAGE:4830673, containing frame-shift errors PA
X75897.1 H.sapiens mRNA for G-protein coupled kinase 4 P
X98118.1 H.sapiens GRK4A gene PA
X97879.1 H.sapiens mRNA for G protein coupled receptor kinase, GRK4B PA
X97880.1 H.sapiens mRNA for G protein coupled receptor kinase, GRK4C PA
X97881.1 H.sapiens mRNA for G protein coupled receptor kinase, GRK4D PA
BC039732.1 Homo sapiens, clone IMAGE:5770079, mRNA A

EST sequences (10 of 78) [Show all sequences]

AA905915.1 Clone IMAGE:1505383 mixed 3' read
AA927880.1 Clone IMAGE:1541378 mixed 3' read P
AI150462.1 Clone IMAGE:1752582 testis 3' read
AI217808.1 Clone IMAGE:1755618 testis 3' read
AI204074.1 Clone IMAGE:1735094 testis 3' read
AI243951.1 Clone IMAGE:1853734 mixed 3' read P
AI422096.1 Clone IMAGE:2103417 brain 3' read
AI751426.1 Clone NHTBC_cn09g09 bone
AI751427.1 Clone NHTBC_cn09g09 bone
AI798928.1 Clone IMAGE:2348753 mixed 3' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help