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UGID:180704     UniGene Hs.298280     Homo sapiens (human)   ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1)

Human protein-coding gene ATP5A1. Represented by 9784 ESTs from 665 cDNA libraries. EST representation biased toward retinoblastoma. Corresponds to 5 reference sequences (different isoforms). [UniGene 180704 - Hs.298280]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001129208.1 ATP5A1 gene product P. troglodytes 100.0 552
NP_004037.1 ATP5A1 gene product H. sapiens 100.0 552
XP_003914389.1 PREDICTED: ATP synthase subunit alpha, mitochondrial P. anubis 100.0 502
XP_001089681.2 PREDICTED: ATP synthase subunit alpha, mitochondrial M. mulatta 99.8 552
XP_002713558.1 PREDICTED: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit-like O. cuniculus 99.8 552
XP_001916279.2 PREDICTED: ATP synthase subunit alpha, mitochondrial E. caballus 99.8 502
NP_031531.1 Atp5a1 gene product M. musculus 99.6 552
XP_852877.2 PREDICTED: ATP synthase subunit alpha, mitochondrial isoform 2 C. lupus familiaris 99.6 552
NP_001172071.1 ATP5A1 gene product S. scrofa 99.6 552
NP_777109.1 ATP5A1 gene product B. taurus 99.6 552
XP_004020569.1 PREDICTED: ATP synthase subunit alpha, mitochondrial isoform 1 O. aries 99.6 552
NP_001081246.1 ATP synthase subunit alpha, mitochondrial X. laevis 98.7 552
NP_001070823.1 atp5a1 gene product D. rerio 98.2 550
NP_726243.1 bellwether D. melanogaster 92.8 551
NP_001021529.1 Protein H28O16.1, isoform d C. elegans 91.9 509
NP_085571.2 ATPase subunit 1 A. thaliana 84.2 500
XP_965645.1 ATP synthase alpha chain, mitochondrial precursor N. crassa 83.8 550
XP_001699641.1 mitochondrial F1F0 ATP synthase, alpha subunit C. reinhardtii 83.0 516
NP_009453.2 F1F0 ATP synthase subunit alpha S. cerevisiae 82.3 542
Other hits (2 of 56) [Show all]SpeciesId(%)Len(aa)
NP_075581.1 Atp5a1 gene product R. norvegicus 99.5 552
XP_001364704.1 PREDICTED: ATP synthase subunit alpha, mitochondrial-like M. domestica 99.5 552

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: retinoblastoma [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: eye; brain; heart; testis; intestine; uncharacterized tissue; kidney; lung; placenta; thymus; uterus; skin; liver; stomach; embryonic tissue; muscle; connective tissue; blood; adrenal gland; prostate; lymph; spleen; mammary gland; ovary; mixed; ascites; cervix; pharynx; pancreas; esophagus; bladder; umbilical cord; thyroid; trachea; vascular; bone marrow; salivary gland; pituitary gland; adipose tissue; bone; tonsil; lymph node; mouth; larynx; nerve; ear; ganglia; pineal gland; spinal cord
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 18
Map position: 18q21
UniSTS entry: Chr 16 STS-AA020987
UniSTS entry: Chr 18 RH11585 [Map Viewer]
UniSTS entry: Chr 16 D16S2555E
UniSTS entry: Chr 2 WI-14803 [Map Viewer]
UniSTS entry: Chr 1 L17705
UniSTS entry: Chr 2 SHGC-32692 [Map Viewer]
UniSTS entry: Chr 2 RH47190 [Map Viewer]
UniSTS entry: Chr 2 G20544
UniSTS entry: Chr 2 A005V45 [Map Viewer]
UniSTS entry: Chr 1 L17971
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (30)

BT007209.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle mRNA, complete cds P
AK129900.1 Homo sapiens cDNA FLJ26390 fis, clone HRT07407, highly similar to ATP synthase alpha chain, mitochondrial precursor (EC 3.6.1.34) P
AK129804.1 Homo sapiens cDNA FLJ26293 fis, clone DMC07062, highly similar to ATP synthase alpha chain, mitochondrial precursor (EC 3.6.1.34) P
AK129739.1 Homo sapiens cDNA FLJ26228 fis, clone ADG08878, highly similar to ATP synthase alpha chain, mitochondrial precursor (EC 3.6.1.34) P
NM_004046.5 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA PA
D14710.1 Homo sapiens mRNA for ATP synthase alpha subunit, complete cds P
BC064562.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone MGC:74538 IMAGE:5582043), complete cds PA
BC067385.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone MGC:60022 IMAGE:5491013), complete cds PA
NM_001001937.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA P
NM_001001935.2 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1), transcript variant 4, mRNA PA
CR627212.1 Homo sapiens mRNA; cDNA DKFZp686N10225 (from clone DKFZp686N10225) PA
BC003119.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone IMAGE:3356657), partial cds PA
BC008028.2 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone IMAGE:3608797), partial cds PA
BC007299.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone IMAGE:3351710), partial cds PA
BC011384.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone MGC:9384 IMAGE:3867375), complete cds PA
BC016046.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone MGC:20426 IMAGE:4646761), complete cds PA
BC019310.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone MGC:4207 IMAGE:2823663), complete cds PA
AK289457.1 Homo sapiens cDNA FLJ77837 complete cds PA
AK310051.1 Homo sapiens cDNA, FLJ17093 P
X59066.1 Human mRNA for mitochondrial ATP synthase (F1-ATPase) alpha subunit PA
AK098765.1 Homo sapiens cDNA FLJ25899 fis, clone CBR04003, highly similar to ATP SYNTHASE ALPHA CHAIN, MITOCHONDRIAL PRECURSOR (EC 3.6.1.34) P
AK092735.1 Homo sapiens cDNA FLJ35416 fis, clone SMINT2000694, highly similar to ATP synthase subunit alpha, mitochondrial precursor (EC 3.6.3.14) P
AK302272.1 Homo sapiens cDNA FLJ54107 complete cds, highly similar to ATP synthase subunit alpha, mitochondrial precursor (EC 3.6.3.14) PA
AK294804.1 Homo sapiens cDNA FLJ54625 complete cds, highly similar to ATP synthase subunit alpha, mitochondrial precursor (EC 3.6.3.14) P
BC028335.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone IMAGE:4705390) PA
X65460.1 H.sapiens mRNA for mitochondrial ATP synthase P
NM_001257335.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1), transcript variant 5, mRNA PA
NM_001257334.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA PA
BC039135.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone MGC:17237 IMAGE:3873390), complete cds PA
BC042694.1 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mRNA (cDNA clone IMAGE:3871266) PA

EST sequences (10 of 9784) [Show all sequences]

AA836842.1 Clone IMAGE:1422690 kidney
AA973964.1 Clone IMAGE:1585218 lung 3' read
AA974170.1 Clone IMAGE:1586243 uncharacterized tissue 3' read A
AA977441.1 Clone IMAGE:1591057 kidney 3' read PA
AI003465.1 Clone IMAGE:1698850 kidney 3' read PA
AI002767.1 Clone IMAGE:1699246 kidney 3' read PA
AI015654.1 Clone IMAGE:1635549 kidney 3' read A
AA947104.1 Clone IMAGE:1561951 mixed 3' read PA
AI049768.1 Clone IMAGE:1699833 kidney 3' read A
AI075272.1 Clone IMAGE:1671122 uncharacterized tissue 3' read PA


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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