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UGID:178525     UniGene Hs.289123     Homo sapiens (human)   DCTN2
Dynactin 2 (p50) (DCTN2)

Human protein-coding gene DCTN2. Represented by 1486 ESTs from 471 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 178525 - Hs.289123]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003313609.1 PREDICTED: dynactin subunit 2 isoform 1 P. troglodytes 100.0 405
NP_006391.1 DCTN2 gene product H. sapiens 100.0 405
XP_001116130.1 PREDICTED: dynactin subunit 2 isoform 3 M. mulatta 99.8 405
XP_003906704.1 PREDICTED: dynactin subunit 2 isoform 3 P. anubis 99.8 405
NP_001177383.1 Dctn2 gene product M. musculus 98.0 406
NP_001080607.1 dynactin subunit 2-B X. laevis 86.8 402
NP_957460.1 dctn2 gene product D. rerio 75.8 404
Other hits (2 of 16) [Show all]SpeciesId(%)Len(aa)
XP_002720963.1 PREDICTED: dynactin 2 isoform 1 O. cuniculus 99.3 406
XP_849674.1 PREDICTED: dynactin subunit 2 isoform 2 C. lupus familiaris 98.8 407

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; uncharacterized tissue; testis; lung; uterus; intestine; placenta; embryonic tissue; skin; kidney; mixed; eye; prostate; liver; heart; ovary; connective tissue; thymus; pancreas; mammary gland; blood; cervix; adrenal gland; stomach; muscle; lymph; bone; mouth; salivary gland; epididymis; larynx; amniotic fluid; trachea; pharynx; ascites; bone marrow; pituitary gland; vascular; spleen; lymph node; esophagus; thyroid; umbilical cord; bladder; ear; nerve; adipose tissue; ganglia; pineal gland; spinal cord
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12q13.3
UniSTS entry: Chr 12 STS-U50733
UniSTS entry: Chr 12 RH70660 [Map Viewer]
UniSTS entry: Chr 12 D10Wsu93e
UniSTS entry: Chr 12 DCTN2
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (15)

AY189155.1 Homo sapiens p50 dynamitin mRNA, complete cds P
NM_006400.4 Homo sapiens dynactin 2 (p50) (DCTN2), transcript variant 1, mRNA P
AK222693.1 Homo sapiens mRNA for dynactin 2 variant, clone: CBR05685 P
AK022171.1 Homo sapiens cDNA FLJ12109 fis, clone MAMMA1000019
BC000718.2 Homo sapiens dynactin 2 (p50), mRNA (cDNA clone MGC:1336 IMAGE:3504109), complete cds PA
U50733.1 Human dynamitin mRNA, complete cds P
BC009468.1 Homo sapiens dynactin 2 (p50), mRNA (cDNA clone MGC:16056 IMAGE:3613836), complete cds PA
BC014083.2 Homo sapiens dynactin 2 (p50), mRNA (cDNA clone MGC:20331 IMAGE:4303142), complete cds PA
AK055682.1 Homo sapiens cDNA FLJ31120 fis, clone IMR322000730, highly similar to Dynactin subunit 2 PA
AK292364.1 Homo sapiens cDNA FLJ77785 complete cds P
AK314705.1 Homo sapiens cDNA, FLJ95559, Homo sapiens dynactin 2 (p50) (DCTN2), mRNA P
AK098794.1 Homo sapiens cDNA FLJ25928 fis, clone CBR05333, highly similar to DYNACTIN, 50 KDA ISOFORM P
AK096242.1 Homo sapiens cDNA FLJ38923 fis, clone NT2NE2011823, highly similar to Dynactin subunit 2 P
NM_001261413.1 Homo sapiens dynactin 2 (p50) (DCTN2), transcript variant 3, mRNA P
NM_001261412.1 Homo sapiens dynactin 2 (p50) (DCTN2), transcript variant 2, mRNA P

EST sequences (10 of 1486) [Show all sequences]

AA865743.1 Clone IMAGE:1469245 uncharacterized tissue 3' read A
AA975254.1 Clone IMAGE:1558827 lung 3' read A
AA987212.1 Clone IMAGE:1603308 lung 3' read
AA995525.1 Clone IMAGE:1606644 kidney 3' read A
AI003962.1 Clone IMAGE:1624438 embryonic tissue 3' read A
AI015224.1 Clone IMAGE:1624080 embryonic tissue 3' read A
R19450.1 Clone IMAGE:33487 brain 5' read
AI090327.1 Clone IMAGE:1672266 uncharacterized tissue 3' read
AI094339.1 Clone IMAGE:1692010 heart 3' read A
AI127570.1 Clone IMAGE:1710289 uterus 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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