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UGID:174904     UniGene Hs.278573     Homo sapiens (human)   CD59
CD59 molecule, complement regulatory protein (CD59)

Human protein-coding gene CD59. Represented by 1741 ESTs from 490 cDNA libraries. Corresponds to 8 reference sequences (different isoforms). [UniGene 174904 - Hs.278573]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000602.1 CD59 gene product H. sapiens 100.0 127
NP_058030.1 H2afz gene product M. musculus 98.9 88
NP_001036788.1 h2afvb gene product D. rerio 97.7 88
NP_524519.1 histone H2A variant, isoform A D. melanogaster 96.6 88
NP_001087351.1 MGC85536 protein X. laevis 96.6 88
NP_500569.1 Protein HTZ-1 C. elegans 89.9 89
Other hits (2 of 36) [Show all]SpeciesId(%)Len(aa)
NP_073165.1 H2afz gene product R. norvegicus 98.9 88
XP_003434076.1 PREDICTED: histone H2A.Z C. lupus familiaris 98.9 88

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: placenta; brain; skin; connective tissue; lung; uncharacterized tissue; pancreas; mammary gland; kidney; uterus; testis; stomach; mixed; heart; eye; intestine; thyroid; blood; liver; ovary; ganglia; vascular; pharynx; embryonic tissue; muscle; thymus; trachea; prostate; mouth; cervix; bone; bladder; parathyroid; adrenal gland; pituitary gland; esophagus; ear; ascites; larynx; amniotic fluid; bone marrow; nerve; umbilical cord; adipose tissue; spleen; salivary gland; tonsil; pineal gland; lymph node
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11p13
UniSTS entry: Chr 11 CD59
UniSTS entry: Chr 11 D11S3984 [Map Viewer]
UniSTS entry: Chr 11 STS-M34671 [Map Viewer]
UniSTS entry: Chr 11 RH44913
UniSTS entry: Chr 11 RH18284
UniSTS entry: Chr 11 SHGC-32142 [Map Viewer]
UniSTS entry: Chr 11 HUM0S15C02 [Map Viewer]
UniSTS entry: Chr 11 STS-N37061 [Map Viewer]
UniSTS entry: Chr 11 D11S4717
UniSTS entry: Chr 11 A004V27 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

AL049957.1 Homo sapiens mRNA; cDNA DKFZp564J0323 (from clone DKFZp564J0323) A
AL080087.1 Homo sapiens mRNA; cDNA DKFZp564K1662 (from clone DKFZp564K1662) A
NM_203330.2 Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 1, mRNA PA
NM_203331.2 Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 4, mRNA PA
NM_203329.2 Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 3, mRNA PA
M34671.1 Human lymphocytic antigen CD59/MEM43 mRNA, complete cds P
NM_000611.5 Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 2, mRNA PA
M95708.1 Homo sapiens Ly-6-like protein (CD59) mRNA, complete cds P
X16447.1 Human mRNA for CD59, an LY-6-like protein regulating complement membrane attack P
X17198.1 Human mRNA for CD59 antigen P
BC001506.2 Homo sapiens CD59 molecule, complement regulatory protein, mRNA (cDNA clone MGC:2354 IMAGE:2988140), complete cds PA
AK311778.1 Homo sapiens cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA P
AK309894.1 Homo sapiens cDNA, FLJ99935 P
NM_001127227.1 Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 8, mRNA PA
NM_001127226.1 Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 7, mRNA PA
NM_001127225.1 Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 6, mRNA PA
NM_001127223.1 Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 5, mRNA PA
X84805.1 H.sapiens mRNA for IL-1/TNF inducible EST (clone MEC-205)
BC033226.1 Homo sapiens CD59 molecule, complement regulatory protein, mRNA (cDNA clone IMAGE:5088648), with apparent retained intron A

EST sequences (10 of 1741) [Show all sequences]

AA968816.1 Clone IMAGE:1570042 lung 3' read
AA973635.1 Clone IMAGE:1569401 lung 3' read
AA977111.1 Clone IMAGE:1587268 uncharacterized tissue 3' read A
AA977367.1 Clone IMAGE:1588962 kidney 3' read
AA984190.1 Clone IMAGE:1629585 brain 3' read
AA906818.1 Clone IMAGE:1519593 uncharacterized tissue 3' read
AA910868.1 Clone IMAGE:1520747 kidney 3' read
AI003551.1 Clone IMAGE:1387868 parathyroid 3' read
AA927012.1 Clone IMAGE:1552414 uncharacterized tissue 3' read
AI025262.1 Clone IMAGE:1641375 testis 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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