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UGID:172147     UniGene Hs.264887     Homo sapiens (human)   FGFR1
Fibroblast growth factor receptor 1 (FGFR1)

Human protein-coding gene FGFR1. Represented by 887 ESTs from 281 cDNA libraries. Corresponds to 9 reference sequences (different isoforms). [UniGene 172147 - Hs.264887]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001167538.1 FGFR1 gene product H. sapiens 100.0 852
XP_001171131.1 PREDICTED: fibroblast growth factor receptor 1 isoform 10 P. troglodytes 100.0 820
XP_003902710.1 PREDICTED: fibroblast growth factor receptor 1 P. anubis 100.0 819
XP_001090823.2 PREDICTED: basic fibroblast growth factor receptor 1 isoform 1 M. mulatta 100.0 732
XP_002720823.1 PREDICTED: fibroblast growth factor receptor 1-like isoform 1 O. cuniculus 99.9 820
XP_001492195.1 PREDICTED: basic fibroblast growth factor receptor 1 isoform 1 E. caballus 99.9 819
NP_034336.2 Fgfr1 gene product M. musculus 99.8 821
XP_003639610.1 PREDICTED: fibroblast growth factor receptor 1-like C. lupus familiaris 99.8 819
NP_001103677.1 FGFR1 gene product B. taurus 99.8 819
XP_001928713.3 PREDICTED: basic fibroblast growth factor receptor 1 isoform 1 S. scrofa 99.6 826
XP_004021834.1 PREDICTED: fibroblast growth factor receptor 1 isoform 3 O. aries 99.6 826
NP_001084333.1 fibroblast growth factor receptor 1 precursor X. laevis 88.9 813
NP_694494.1 fgfr1a gene product D. rerio 87.5 795
NP_732286.1 heartless, isoform A D. melanogaster 57.7 404
NP_001024723.1 Protein EGL-15, isoform b C. elegans 55.9 372
Other hits (2 of 33) [Show all]SpeciesId(%)Len(aa)
NP_077060.1 Fgfr1 gene product R. norvegicus 99.3 821
XP_003339702.1 PREDICTED: basic fibroblast growth factor receptor 1 M. domestica 98.5 819

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; embryonic tissue; uncharacterized tissue; uterus; ovary; placenta; connective tissue; pancreas; lung; eye; kidney; cervix; trachea; esophagus; mammary gland; bone; thymus; umbilical cord; epididymis; ear; adrenal gland; liver; mixed; muscle; intestine; prostate; nerve; mouth; larynx; skin; heart; stomach; spleen; ganglia; lymph node; bone marrow; blood; vascular; thyroid; pituitary gland; tonsil; pineal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 8
Map position: 8p12
UniSTS entry: Chr 8 RH78260
UniSTS entry: Chr 8 RH70870
UniSTS entry: Chr 8 RH16447
UniSTS entry: Chr 8 MARC_14569-14570:1009480763:3
UniSTS entry: Chr 8 SHGC-32099 [Map Viewer]
UniSTS entry: Chr 8 FGFR1_V35
UniSTS entry: Chr 8 SHGC-37155 [Map Viewer]
UniSTS entry: Chr 8 RH48951
UniSTS entry: Chr 8 D2S2823 [Map Viewer]
UniSTS entry: Chr 1 D10S16
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (41)

M34641.1 Human fibroblast growth factor (FGF) receptor-1 mRNA, complete cds P
M34185.1 Human fibroblast growth factor receptor (FGFr) transmembrane form mRNA, complete cds PA
M34186.1 Human fibroblast growth factor receptor (FGFr) transmembrane form mRNA, complete cds PA
M34187.1 Human fibroblast growth factor receptor (FGFr) transmembrane form mRNA, complete cds PA
M34188.1 Human fibroblast growth factor receptor (FGFr) secreted form mRNA, complete cds P
M60485.1 Human fibroblast growth factor receptor mRNA, complete cds PA
M63887.1 Human heparin-binding growth factor receptor (HBGF-R-alpha-a1) mRNA, complete cds P
AF173898.1 Homo sapiens MSTP123 (MST123) mRNA, complete cds A
AK130555.1 Homo sapiens cDNA FLJ27045 fis, clone SLV09155
NM_015850.3 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 2, mRNA PA
M37722.1 Human shorter form basic fibroblast growth factor (bFGF) receptor mRNA, complete cds P
BC091494.1 Homo sapiens fibroblast growth factor receptor 1, mRNA (cDNA clone MGC:111078 IMAGE:30387634), complete cds PA
AB208919.1 Homo sapiens mRNA for fibroblast growth factor receptor 1 isoform 1 precursor variant protein P
AK223126.1 Homo sapiens mRNA for fibroblast growth factor receptor 1 isoform 6 precursor variant, clone: KDN01452 P
AK222718.1 Homo sapiens mRNA for fibroblast growth factor receptor 1 isoform 2 precursor variant, clone: COL06728 PA
NM_023105.2 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 3, mRNA PA
NM_023106.2 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 4, mRNA PA
NM_023110.2 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 1, mRNA PA
X51803.1 Human mRNA for fibroblast growth factor (FGF) receptor P
X52833.1 Human flg mRNA for fibroblast growth factor receptor-FLG P
AK292470.1 Homo sapiens cDNA FLJ75115 complete cds, highly similar to Homo sapiens fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) (FGFR1), transcript variant 3, mRNA P
AK291754.1 Homo sapiens cDNA FLJ75121 complete cds, highly similar to Homo sapiens fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) (FGFR1), transcript variant 2, mRNA P
EF525171.1 Homo sapiens FGFR1/PLAG1 fusion variant 4 (FGFR1/PLAG1 fusion) mRNA, partial sequence
AK309947.1 Homo sapiens cDNA, FLJ99988 P
BC018128.1 Homo sapiens fibroblast growth factor receptor 1, mRNA (cDNA clone MGC:9218 IMAGE:3896359), complete cds PA
BC015035.1 Homo sapiens fibroblast growth factor receptor 1, mRNA (cDNA clone MGC:9228 IMAGE:3911101), complete cds PA
X57122.1 Human mRNA for fibroblast growth receptor 2-Ig domain P
X57119.1 Human mRNA for fibroblast growth receptor 2-Ig domain+2 AA insert P
X57120.1 Human mRNA for fibroblast growth receptor 3-Ig domain P
EU826597.1 Homo sapiens soluble FGFR1 variant 2 (FGFR1) mRNA, complete cds, alternatively spliced P
EU826596.1 Homo sapiens soluble FGFR1 variant 1 (FGFR1) mRNA, complete cds, alternatively spliced P
X57121.1 Human mRNA for fibroblast growth receptor 3-Ig domain+2 AA insert P
Y00665.1 Human flg (fms-like gene) mRNA for putative protein tyrosine kinase (partial) P
S76658.1 fibroblast growth factor receptor FGFR-1 secreted form {alternatively spliced 3' region, deletion of second and third Ig loops} [human, pancreatic cancer cell line PT45, mRNA Partial, 278 nt]
X66945.1 H.sapiens N-sam mRNA for fibroblast growth factor receptor PA
FJ809917.1 Homo sapiens fibroblast growth factor receptor 1 isoform 1 (FGFR1) mRNA, complete cds, alternatively spliced PA
NM_001174067.1 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 14, mRNA PA
NM_001174066.1 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 13, mRNA PA
NM_001174065.1 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 12, mRNA PA
NM_001174064.1 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 11, mRNA PA
NM_001174063.1 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 10, mRNA PA

EST sequences (10 of 887) [Show all sequences]

AA988919.1 Clone IMAGE:1602278 lung 3' read
AA902794.1 Clone IMAGE:1519140 uncharacterized tissue 3' read
AI002948.1 Clone IMAGE:1699512 kidney 3' read
AI005374.1 Clone IMAGE:1624888 embryonic tissue 3' read
AA922587.1 Clone IMAGE:1551676 uncharacterized tissue 3' read
AI032260.1 Clone IMAGE:1603779 lung 3' read
AI049904.1 Clone IMAGE:1700220 kidney 3' read
AI050058.1 Clone IMAGE:1700273 kidney 3' read
AI074256.1 Clone IMAGE:1682135 skin 3' read A
AI092048.1 Clone IMAGE:1694292 heart 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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