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UGID:164670     UniGene Hs.212838     Homo sapiens (human)   A2M
Alpha-2-macroglobulin (A2M)

Human protein-coding gene A2M. Represented by 2769 ESTs from 447 cDNA libraries. Corresponds to reference sequence NM_000014.4. [UniGene 164670 - Hs.212838]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000005.2 A2M gene product H. sapiens 100.0 1473
XP_001139819.1 PREDICTED: alpha-2-macroglobulin isoform 8 P. troglodytes 99.9 1473
NP_783327.2 alpha-2-macroglobulin-P precursor M. musculus 80.1 1467
NP_001165531.1 alpha-2-macroglobulin precursor X. laevis 58.4 1460
XP_001921577.2 PREDICTED: alpha-2-macroglobulin-like D. rerio 54.7 794
NP_723300.1 thiolester containing protein II, isoform E D. melanogaster 49.5 210
Other hits (2 of 34) [Show all]SpeciesId(%)Len(aa)
XP_003905997.1 PREDICTED: alpha-2-macroglobulin-like isoform 1 P. anubis 97.2 1473
XP_001114328.1 PREDICTED: alpha-2-macroglobulin isoform 3 M. mulatta 97.0 1473

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: liver; brain; lung; placenta; uterus; intestine; tonsil; uncharacterized tissue; trachea; testis; connective tissue; skin; prostate; muscle; stomach; mixed; kidney; embryonic tissue; heart; eye; mouth; spleen; pancreas; ganglia; mammary gland; thyroid; adrenal gland; thymus; bone; ear; pharynx; adipose tissue; blood; esophagus; larynx; ovary; pineal gland; vascular; spinal cord; nerve; parathyroid; bladder; pituitary gland; cervix; lymph node; bone marrow; epididymis; peritoneum
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12p13.31
UniSTS entry: Chr 12 RH11157
UniSTS entry: Chr 12 SGC31674 [Map Viewer]
UniSTS entry: Chr 12 RH1601
UniSTS entry: Chr 12 G44356
UniSTS entry: Chr 12 D12S1160E
UniSTS entry: Chr 12 RH70338
UniSTS entry: Chr 12 SGC33440 [Map Viewer]
UniSTS entry: Chr 12 G59851
UniSTS entry: Chr 12 PMC311069P4
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

BX647329.1 Homo sapiens mRNA; cDNA DKFZp779L1515 (from clone DKFZp779L1515) PA
NM_000014.4 Homo sapiens alpha-2-macroglobulin (A2M), mRNA PA
M11313.1 Human alpha-2-macroglobulin mRNA, complete cds P
M36501.1 Human alpha-2-macroglobulin mRNA, 3' end P
BC026246.1 Homo sapiens alpha-2-macroglobulin, mRNA (cDNA clone IMAGE:4733707), complete cds PA
AY591530.1 Homo sapiens alpha 2 macroglobulin (A2M) mRNA, complete cds P
CR749334.1 Homo sapiens mRNA; cDNA DKFZp779B086 (from clone DKFZp779B086) PA
AB209614.2 Homo sapiens mRNA for alpha 2 macroglobulin variant, partial cds PA
AK307832.1 Homo sapiens cDNA, FLJ97780 P
AK312482.1 Homo sapiens cDNA, FLJ92841 P
BC040071.1 Homo sapiens alpha-2-macroglobulin, mRNA (cDNA clone MGC:47683 IMAGE:6056126), complete cds PA

EST sequences (10 of 2769) [Show all sequences]

AA865511.1 Clone IMAGE:1459279 kidney 3' read PA
AA864272.1 Clone IMAGE:1460209 kidney 3' read P
AA962396.1 Clone IMAGE:1569977 lung 3' read PA
AA962464.1 Clone IMAGE:1573566 kidney 3' read PA
AA905927.1 Clone IMAGE:1505413 mixed 3' read PA
AA968826.1 Clone IMAGE:1570041 lung 3' read PA
AA976234.1 Clone IMAGE:1567683 lung 3' read PA
AA976537.1 Clone IMAGE:1588821 kidney 3' read PA
R14698.1 Clone IMAGE:29963 brain 5' read P
AA983221.1 Clone IMAGE:1591826 kidney 3' read PA

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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