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UGID:162811     UniGene Hs.202672     Homo sapiens (human)   DNMT1
DNA (cytosine-5-)-methyltransferase 1 (DNMT1)

Human protein-coding gene DNMT1. Represented by 597 ESTs from 251 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 162811 - Hs.202672]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001163764.1 PREDICTED: DNA (cytosine-5)-methyltransferase 1 isoform 10 P. troglodytes 100.0 1675
NP_001124295.1 DNMT1 gene product H. sapiens 100.0 1631
XP_001104704.2 PREDICTED: DNA (cytosine-5)-methyltransferase 1 M. mulatta 99.8 1279
NP_034196.5 Dnmt1 gene product M. musculus 86.6 1618
NP_571264.1 dnmt1 gene product D. rerio 84.8 1325
NP_001084021.1 DNA (cytosine-5-)-methyltransferase 1 X. laevis 84.3 1440
NP_199727.1 DNA (cytosine-5)-methyltransferase 1 A. thaliana 54.6 456
XP_001698604.1 cytosine-C5 specific DNA methyltransferase C. reinhardtii 52.4 496
Other hits (2 of 40) [Show all]SpeciesId(%)Len(aa)
XP_003914916.1 PREDICTED: DNA (cytosine-5)-methyltransferase 1 P. anubis 99.0 1705
XP_533919.3 PREDICTED: DNA (cytosine-5)-methyltransferase 1 C. lupus familiaris 95.7 1610

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lymph node; brain; testis; uncharacterized tissue; mixed; embryonic tissue; placenta; uterus; intestine; mammary gland; lymph; blood; skin; muscle; ovary; thyroid; ear; adrenal gland; thymus; kidney; cervix; pancreas; larynx; bladder; ascites; lung; mouth; eye; liver; stomach; connective tissue; prostate; bone marrow; nerve; heart; bone; spleen; trachea; epididymis; pineal gland; vascular; pharynx
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19p13.2
UniSTS entry: Chr 19 RH18124
UniSTS entry: Chr 19 D19S830 [Map Viewer]
UniSTS entry: Chr 15 Rnu2
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

AK122759.1 Homo sapiens cDNA FLJ16293 fis, clone OCBBF2021518, highly similar to DNA (cytosine-5)-methyltransferase 1 (EC P
NM_001379.2 Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 2, mRNA PA
AF180682.1 Homo sapiens DNA (cytosine-5)-methyltransferase mRNA, complete cds PA
AY927518.1 Homo sapiens mRNA sequence P
AB209413.2 Homo sapiens mRNA for DNA (cytosine-5-)-methyltransferase 1 variant, partial cds PA
BC126227.1 Homo sapiens DNA (cytosine-5-)-methyltransferase 1, mRNA (cDNA clone MGC:161505 IMAGE:8991943), complete cds P
X63692.1 H.sapiens mRNA for DNA (cytosin-5)-methyltransferase PA
NM_001130823.1 Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 1, mRNA PA
BC144093.1 Homo sapiens DNA (cytosine-5-)-methyltransferase 1, mRNA (cDNA clone MGC:177630 IMAGE:9052613), complete cds P

EST sequences (10 of 597) [Show all sequences]

R17473.1 Clone IMAGE:32332 brain 5' read P
AI003012.1 Clone IMAGE:1683909 brain 3' read P
AI003132.1 Clone IMAGE:1700009 kidney 3' read
AI003705.1 Clone IMAGE:392109 pineal gland 3' read A
AI033322.1 Clone IMAGE:1655125 mixed 3' read A
AI078013.1 Clone IMAGE:1674424 mixed 3' read A
AI141776.1 Clone IMAGE:1690752 mixed 3' read A
BX109812.1 Clone IMAGp998O18272_;_IMAGE:45941 brain P
AI174310.1 Clone IMAGE:1577121 spleen 3' read
AI188287.1 Clone IMAGE:1723052 placenta 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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