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UGID:161989     UniGene Hs.199743     Homo sapiens (human)   ME3
Malic enzyme 3, NADP(+)-dependent, mitochondrial (ME3)

Human protein-coding gene ME3. Represented by 220 ESTs from 128 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 161989 - Hs.199743]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001155058.1 ME3 gene product H. sapiens 100.0 603
XP_001103502.1 PREDICTED: NADP-dependent malic enzyme, mitochondrial isoform 2 M. mulatta 100.0 541
XP_508682.2 PREDICTED: NADP-dependent malic enzyme, mitochondrial isoform 4 P. troglodytes 99.8 603
NP_852072.2 Me3 gene product M. musculus 97.3 603
NP_001082825.1 me3 gene product D. rerio 83.7 570
NP_001088519.1 malic enzyme 3, NADP(+)-dependent, mitochondrial X. laevis 82.7 607
NP_651959.1 malic enzyme b, isoform A D. melanogaster 61.6 578
NP_496968.1 Protein MEN-1 C. elegans 59.9 563
NP_178093.1 NADP-malic enzyme 4 A. thaliana 55.7 630
XP_001692779.1 NADP malic enzyme C. reinhardtii 51.8 454
XP_965588.1 hypothetical protein NCU02906 N. crassa 47.4 272
Other hits (2 of 53) [Show all]SpeciesId(%)Len(aa)
XP_001493140.2 PREDICTED: NADP-dependent malic enzyme, mitochondrial E. caballus 98.9 541
XP_002708696.1 PREDICTED: mitochondrial malic enzyme 3 O. cuniculus 98.8 603

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; kidney; lung; mixed; intestine; heart; pancreas; eye; uncharacterized tissue; testis; mammary gland; placenta; trachea; thymus; connective tissue; skin; adipose tissue; parathyroid; nerve; pineal gland; spleen; vascular; stomach; uterus; ovary; thyroid; embryonic tissue; adrenal gland; prostate; liver; ascites; cervix
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11cen-q22.3
UniSTS entry: Chr 11 HSC2HH112 [Map Viewer]
UniSTS entry: Chr 11 MARC_13809-13810:1046871162:1
UniSTS entry: Chr 11 WI-21566 [Map Viewer]
UniSTS entry: Chr 11 WI-16172 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

NM_006680.2 Homo sapiens malic enzyme 3, NADP(+)-dependent, mitochondrial (ME3), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA P
AY424278.1 Homo sapiens mitochondrial NADP(+)-dependent malic enzyme 3 (ME3) mRNA, complete cds, alternatively spliced; nuclear gene for mitochondrial product P
NM_001014811.1 Homo sapiens malic enzyme 3, NADP(+)-dependent, mitochondrial (ME3), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA P
BC022472.2 Homo sapiens malic enzyme 3, NADP(+)-dependent, mitochondrial, mRNA (cDNA clone MGC:26257 IMAGE:4812045), complete cds PA
AK313695.1 Homo sapiens cDNA, FLJ94285, highly similar to Homo sapiens malic enzyme 3, NADP(+)-dependent, mitochondrial(ME3), nuclear gene encoding mitochondrial protein, mRNA P
AK092181.1 Homo sapiens cDNA FLJ34862 fis, clone NT2NE2013547, highly similar to NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL PRECURSOR (EC 1.1.1.40) P
AK300974.1 Homo sapiens cDNA FLJ58694 complete cds, highly similar to NADP-dependent malic enzyme, mitochondrial precursor (EC 1.1.1.40) P
X79440.1 H.sapiens mRNA for NADP+-dependent malic enzyme P
NM_001161586.1 Homo sapiens malic enzyme 3, NADP(+)-dependent, mitochondrial (ME3), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA PA

EST sequences (10 of 220) [Show all sequences]

AI025453.1 Clone IMAGE:1641416 testis 3' read P
AI026114.1 Clone IMAGE:1645779 parathyroid 3' read
AI088692.1 Clone IMAGE:1686510 brain 3' read P
BX116996.1 Clone IMAGp998H06159_;_IMAGE:35000 brain A
AI206809.1 Clone IMAGE:1756639 lung 3' read P
CB132135.1 Clone L12JSHC0-8-A02 liver 5' read P
CB129831.1 Clone L15CKK1-2-B03 liver 5' read
AI198184.1 Clone IMAGE:1860027 brain 3' read PA
AI245776.1 Clone IMAGE:1870668 kidney 3' read P
AI367113.1 Clone IMAGE:1873955 intestine 3' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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