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UGID:160876     UniGene Hs.192649     Homo sapiens (human)   MRE11A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A)

Human protein-coding gene MRE11A. Represented by 188 ESTs from 116 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 160876 - Hs.192649]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_005582.1 MRE11A gene product H. sapiens 100.0 707
XP_001142422.3 PREDICTED: double-strand break repair protein MRE11A isoform 4 P. troglodytes 99.6 709
XP_003910606.1 PREDICTED: double-strand break repair protein MRE11A isoform 1 P. anubis 99.6 707
NP_061206.1 Mre11a gene product M. musculus 92.9 705
NP_001080975.1 double-strand break repair protein MRE11 X. laevis 82.8 708
NP_001001407.1 mre11a gene product D. rerio 76.8 613
XP_001702831.1 MRE11 eukaryotic DNA repair protein C. reinhardtii 58.6 161
NP_523547.1 meiotic recombination 11 D. melanogaster 55.8 380
NP_200237.1 double-strand break repair protein MRE11 A. thaliana 53.4 367
NP_013951.1 Mre11p S. cerevisiae 51.9 368
XP_963591.2 DNA repair protein rad32 N. crassa 51.5 388
NP_505736.2 Protein MRE-11 C. elegans 51.2 377
Other hits (2 of 58) [Show all]SpeciesId(%)Len(aa)
XP_002799798.1 PREDICTED: double-strand break repair protein MRE11A-like M. mulatta 99.3 697
XP_542244.2 PREDICTED: double-strand break repair protein MRE11A isoform 2 C. lupus familiaris 97.0 707

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: uncharacterized tissue; mixed; embryonic tissue; brain; placenta; lung; kidney; mouth; skin; bone; uterus; esophagus; testis; blood; mammary gland; prostate; muscle; adrenal gland; bladder; spleen; thymus; liver; intestine; connective tissue; thyroid; cervix; eye; nerve; bone marrow; parathyroid; lymph node; larynx; stomach; ovary; pharynx
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11q21
UniSTS entry: Chr 11 MRE11 [Map Viewer]
UniSTS entry: Chr 11 WI-17886 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

AF073362.1 Homo sapiens endo/exonuclease Mre11 (MRE11A) mRNA, complete cds P
BT006730.1 Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae) mRNA, complete cds P
NM_005590.3 Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2, mRNA P
NM_005591.3 Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 1, mRNA P
BC063458.1 Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:74523 IMAGE:5181691), complete cds PA
U37359.1 Homo sapiens MRE11 homologue hMre11 mRNA, complete cds PA
BC005241.1 Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae), mRNA (cDNA clone IMAGE:3997666), complete cds PA
AK308318.1 Homo sapiens cDNA, FLJ98266 P
AK095388.1 Homo sapiens cDNA FLJ38069 fis, clone CTONG2015434, highly similar to DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11A P
BC017823.1 Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae), mRNA (cDNA clone IMAGE:4687479), partial cds PA
AF022778.1 Homo sapiens DNA recombination and repair protein (MRE11B) mRNA, complete cds P

EST sequences (10 of 188) [Show all sequences]

AA974008.1 Clone IMAGE:1586172 uncharacterized tissue 3' read A
AI222049.1 Clone IMAGE:1843482 mixed 3' read
AI288910.1 Clone IMAGE:1879728 mixed 3' read PA
AI480267.1 Clone IMAGE:2157699 mixed 3' read P
AI521096.1 Clone IMAGE:2183681 stomach 3' read PA
AI572202.1 Clone IMAGE:2088945 mixed 3' read A
AU280269.1 Clone N1ESE2001177 uncharacterized tissue 5' read P
AI650940.1 Clone IMAGE:2298639 kidney 3' read
AI652139.1 Clone IMAGE:2308823 uncharacterized tissue 3' read PA
AI703013.1 Clone IMAGE:2336596 lung 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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