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UGID:159070     UniGene Hs.180062     Homo sapiens (human)   PSMB8
Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (PSMB8)

Human protein-coding gene PSMB8. Represented by 577 ESTs from 231 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 159070 - Hs.180062]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_683720.2 PSMB8 gene product H. sapiens 100.0 275
XP_001167272.1 PREDICTED: proteasome subunit beta type-8 isoform 3 P. troglodytes 99.6 275
NP_034854.2 Psmb8 gene product M. musculus 94.2 275
NP_001084323.1 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) X. laevis 83.0 270
NP_571467.2 psmb8 gene product D. rerio 82.2 270
XP_001698605.1 20S proteasome beta subunit E, type beta 5 C. reinhardtii 66.1 251
NP_189265.1 proteasome subunit beta type-5-B A. thaliana 63.7 259
NP_015428.1 proteasome core particle subunit beta 5 S. cerevisiae 62.8 247
NP_652014.1 proteasome beta5 subunit, isoform A D. melanogaster 61.4 277
XP_963951.1 proteasome component PRE2 precursor N. crassa 60.8 245
NP_493558.1 Protein PBS-5 C. elegans 50.4 238
Other hits (2 of 62) [Show all]SpeciesId(%)Len(aa)
XP_001115562.2 PREDICTED: proteasome subunit beta type-8-like M. mulatta 98.5 275
XP_003897470.1 PREDICTED: proteasome subunit beta type-8 isoform 1 P. anubis 97.8 275

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: uncharacterized tissue; intestine; lung; mixed; blood; brain; uterus; stomach; lymph node; kidney; pancreas; skin; mammary gland; prostate; lymph; spleen; vascular; liver; thyroid; salivary gland; placenta; pharynx; connective tissue; tonsil; parathyroid; bladder; ascites; larynx; testis; cervix; eye; embryonic tissue; ovary; thymus; heart; bone; nerve; mouth; umbilical cord; esophagus; bone marrow; adrenal gland
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 6
Map position: 6p21.3
UniSTS entry: Chr 6 D6S2125
UniSTS entry: Chr 6 RH46789 [Map Viewer]
UniSTS entry: Chr 6 GDB:545427
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (7)

NM_004159.4 Homo sapiens proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (PSMB8), transcript variant 1, mRNA PA
CR541661.1 Homo sapiens full open reading frame cDNA clone RZPDo834D1127D for gene PSMB8, proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7); complete cds, without stopcodon P
U17496.1 Human proteasome subunit LMP7 (allele LMP7B) mRNA, complete cds P
U17497.1 Human proteasome subunit LMP7 (allele LMP7C) mRNA, complete cds P
BC001114.2 Homo sapiens proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7), mRNA (cDNA clone MGC:1491 IMAGE:2967119), complete cds PA
X62598.1 H.sapiens RING10 mRNA P
NM_148919.3 Homo sapiens proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (PSMB8), transcript variant 2, mRNA PA

EST sequences (10 of 577) [Show all sequences]

AA974311.1 Clone IMAGE:1585966 uncharacterized tissue 3' read A
AA977083.1 Clone IMAGE:1587169 uncharacterized tissue 3' read P
AA977127.1 Clone IMAGE:1587287 uncharacterized tissue 3' read
AA985004.1 Clone IMAGE:1577189 spleen 3' read PA
AA991364.1 Clone IMAGE:1608916 mammary gland 3' read A
AA993095.1 Clone IMAGE:1625047 embryonic tissue 3' read P
AA897719.1 Clone IMAGE:1504267 mixed 3' read P
AI028759.1 Clone IMAGE:1645391 testis 3' read
AI097400.1 Clone IMAGE:1702937 brain 3' read PA
AA923804.1 Clone IMAGE:1484096 larynx 3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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