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UGID:158829     UniGene Hs.177766     Homo sapiens (human)   PARP1
Poly (ADP-ribose) polymerase 1 (PARP1)

Human protein-coding gene PARP1. Represented by 1259 ESTs from 381 cDNA libraries. Corresponds to reference sequence NM_001618.3. [UniGene 158829 - Hs.177766]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001609.2 PARP1 gene product H. sapiens 100.0 1013
XP_003949754.1 PREDICTED: LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1 P. troglodytes 99.7 1013
NP_031441.2 Parp1 gene product M. musculus 96.0 1013
NP_001081571.1 poly [ADP-ribose] polymerase 1 X. laevis 81.7 1007
NP_001038407.1 poly [ADP-ribose] polymerase 1 D. rerio 78.7 1012
NP_001104452.1 Poly-(ADP-ribose) polymerase, isoform B D. melanogaster 60.1 556
NP_850165.1 Poly [ADP-ribose] polymerase 1 A. thaliana 55.8 495
NP_491072.1 Protein PME-1 C. elegans 51.6 341
XP_960982.2 hypothetical protein NCU08852 N. crassa 49.0 294
Other hits (2 of 53) [Show all]SpeciesId(%)Len(aa)
XP_001090984.1 PREDICTED: poly [ADP-ribose] polymerase 1 isoform 4 M. mulatta 99.1 1013
XP_003893085.1 PREDICTED: poly [ADP-ribose] polymerase 1 P. anubis 98.3 1076

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; embryonic tissue; uncharacterized tissue; intestine; lung; skin; mixed; eye; lymph node; pancreas; placenta; prostate; uterus; lymph; liver; bone marrow; trachea; thyroid; mammary gland; kidney; cervix; tonsil; larynx; connective tissue; amniotic fluid; ovary; muscle; blood; mouth; adrenal gland; esophagus; vascular; thymus; heart; bladder; parathyroid; spleen; ascites; adipose tissue; epididymis; bone; pharynx; pituitary gland; stomach; nerve; ear; pineal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 1
Map position: 1q41-q42
UniSTS entry: Chr 14 RH11161
UniSTS entry: Chr 1 D1S2048E
UniSTS entry: Chr 1 SHGC-76015 [Map Viewer]
UniSTS entry: Chr 1 RH70493 [Map Viewer]
UniSTS entry: Chr 1 G07110
UniSTS entry: Chr 1 SHGC-30345 [Map Viewer]
UniSTS entry: Chr 1 ADPRT_3241
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (15)

AK125650.1 Homo sapiens cDNA FLJ43662 fis, clone SYNOV4005981, highly similar to POLY [ADP-RIBOSE] POLYMERASE (EC 2.4.2.30) P
NM_001618.3 Homo sapiens poly (ADP-ribose) polymerase 1 (PARP1), mRNA PA
M17081.1 Human placental poly(ADP-ribose) polymerase mRNA, partial cds P
M18112.1 Human poly(ADP-ribose) polymerase mRNA, complete cds P
M32721.1 Human poly(ADP-ribose) polymerase mRNA, complete cds P
J03473.1 Human poly(ADP-ribose) synthetase mRNA, complete cds P
AK225654.1 Homo sapiens mRNA for Poly [ADP-ribose] polymerase 1 variant, clone: STM01125 PA
AK312339.1 Homo sapiens cDNA, FLJ92658, highly similar to Homo sapiens poly (ADP-ribose) polymerase family, member 1 (PARP1), mRNA P
AK303340.1 Homo sapiens cDNA FLJ53442 complete cds, highly similar to Poly (ADP-ribose) polymerase 1 (EC 2.4.2.30) P
BC021045.1 Homo sapiens poly (ADP-ribose) polymerase 1, mRNA (cDNA clone IMAGE:2966657) PA
BC018620.1 Homo sapiens poly (ADP-ribose) polymerase 1, mRNA (cDNA clone IMAGE:5015448), partial cds PA
AF401218.1 Homo sapiens poly(ADP-ribose) polymerase mRNA, partial cds
BC014206.2 Homo sapiens poly (ADP-ribose) polymerase 1, mRNA (cDNA clone IMAGE:4643426), partial cds PA
BC008660.1 Homo sapiens poly (ADP-ribose) polymerase family, member 1, mRNA (cDNA clone IMAGE:3866228), with apparent retained intron PA
BC037545.1 Homo sapiens poly (ADP-ribose) polymerase 1, mRNA (cDNA clone MGC:40266 IMAGE:5193735), complete cds PA

EST sequences (10 of 1259) [Show all sequences]

R15839.1 Clone IMAGE:53210 brain 3' read A
R15840.1 Clone IMAGE:53210 brain 5' read
R15230.1 Clone IMAGE:29863 brain 5' read P
AA911044.1 Clone IMAGE:1518485 uncharacterized tissue 3' read A
AI003098.1 Clone IMAGE:1699878 kidney 3' read
AI004633.1 Clone IMAGE:1626048 mixed 3' read P
AI022842.1 Clone IMAGE:1650612 parathyroid 3' read A
R19032.1 Clone IMAGE:33050 brain 5' read P
AI041345.1 Clone IMAGE:1648130 parathyroid 3' read A
AI055962.1 Clone IMAGE:1648278 parathyroid 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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