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UGID:158221     UniGene Hs.172631     Homo sapiens (human)   ITGAM
Integrin, alpha M (complement component 3 receptor 3 subunit) (ITGAM)

Human protein-coding gene ITGAM. Represented by 110 ESTs from 57 cDNA libraries. EST representation biased toward leukemia; adult. Corresponds to 2 reference sequences (different isoforms). [UniGene 158221 - Hs.172631]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001139280.1 ITGAM gene product H. sapiens 100.0 1152
NP_001076429.1 Itgam gene product M. musculus 77.7 1153
Other hits (2 of 13) [Show all]SpeciesId(%)Len(aa)
NP_001181863.1 integrin alpha-M precursor P. troglodytes 99.3 1152
XP_003916861.1 PREDICTED: integrin alpha-M P. anubis 93.2 1130

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: leukemia [show more like this]
adult [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: blood; bone marrow; uncharacterized tissue; mouth; brain; thymus; connective tissue; lung; kidney; lymph node; spleen; placenta; intestine; bone; mammary gland; mixed; nerve; testis
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 16
Map position: 16p11.2
UniSTS entry: Chr 16 RH79892
UniSTS entry: Chr 16 GDB:180920
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (13)

AK127637.1 Homo sapiens cDNA FLJ45735 fis, clone JCMLC2000273, highly similar to Integrin alpha-M precursor P
NM_000632.3 Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit) (ITGAM), transcript variant 2, mRNA P
AY187248.1 Homo sapiens ITGAM isoform 2 (ITGAM) mRNA, partial sequence; alternatively spliced P
AY187247.1 Homo sapiens ITGAM isoform 1 (ITGAM) mRNA, partial sequence; alternatively spliced P
BC096346.3 Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit), mRNA (cDNA clone MGC:117042 IMAGE:40008964), complete cds P
BC096347.3 Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit), mRNA (cDNA clone MGC:117043 IMAGE:40008967), complete cds P
BC096348.3 Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit), mRNA (cDNA clone MGC:117045 IMAGE:40008972), complete cds P
BC099660.3 Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit), mRNA (cDNA clone MGC:117044 IMAGE:40008969), complete cds P
M18044.1 Human CD11b (MAC-1/Mo1/CR3) leukocyte adhesion receptor alpha subunit mRNA, partial cds P
J03925.1 Human Mac-1 gene encoding complement receptor type 3, CD11b, complete cds PA
J04145.1 Human neutrophil adherence receptor alpha-M subunit mRNA P
AK057856.1 Homo sapiens cDNA FLJ25127 fis, clone CBR06564, highly similar to CELL SURFACE GLYCOPROTEIN MAC-1 ALPHA SUBUNIT PRECURSOR P
NM_001145808.1 Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit) (ITGAM), transcript variant 1, mRNA P

EST sequences (10 of 110) [Show all sequences]

BX095806.1 Clone IMAGp998L015064_;_IMAGE:2056464 bone marrow
AI309439.1 Clone IMAGE:2056566 bone marrow 3' read
AI312241.1 Clone IMAGE:2050306 bone marrow 3' read A
AI312338.1 Clone IMAGE:2050215 bone marrow 3' read A
AI312956.1 Clone IMAGE:2050352 bone marrow 3' read A
AI334594.1 Clone IMAGE:2054869 kidney 3' read A
AI340649.1 Clone IMAGE:2056037 bone marrow 3' read
AI349150.1 Clone IMAGE:2049677 bone marrow 3' read A
AI349248.1 Clone IMAGE:2049831 bone marrow 3' read A
AI307732.1 Clone IMAGE:2056464 bone marrow 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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